Do OZEM and WDNA hold the same stocks?

By their latest filings, 13% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, OZEM or WDNA?

OZEM has 27% of its weight in S&P 500 names and WDNA has 26%, so OZEM differs more from the index.

Which is cheaper, OZEM or WDNA?

OZEM charges 0.59% a year and WDNA charges 0.45%, so WDNA is cheaper. Fees come from each fund's prospectus.

Share on X Download as PDF Open live

OZEM vs WDNA: which is really different?

OZEM and WDNA hold 13% of their weight in the same names, and WDNA returned +58.6% over the year. Roundhill GLP-1 & Weight Loss ETF and WisdomTree BioRevolution Fund.

26.6%

OZEM in the S&P 500

25.9%

WDNA in the S&P 500

+14.0%

OZEM total return, 1 year

+58.6%

WDNA total return, 1 year

OZEM · 1 year to Sep 30, 202673% of its weight is outside the S&P 500

27% of OZEM's weight is in S&P 500 companies and 73% is outside the index

WDNA · 1 year to Sep 30, 202674% of its weight is outside the S&P 500

26% of WDNA's weight is in S&P 500 companies and 74% is outside the index

ETFIQ Off-Index Score · OZEM scores higherHow much of it is not the index it is sold as an alternative to?

OZEM 46.9

WDNA 34

0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, OZEM and WDNA hold 13% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and Sep 30, 2026.

50%

half

13% in common

Positions both hold, largest shared weight first

Holding OZEM WDNA

Eli Lilly & Co 12.69% 4.08%

Structure Therapeutics Inc 2.46% 2.12%

AstraZeneca PLC 3.79% 1.83%

Amgen Inc 4.37% 1.54%

Gilead Sciences Inc 1.83% 1.51%

Pfizer Inc 7.69% 1.35%

Viking Therapeutics Inc 5.47% 0.93%

Only in OZEM

Novo Nordisk A/S 11.09%

CSPC Pharmaceutical Group Ltd 6.52%

Kailera Therapeutics Inc 5.17%

Chugai Pharmaceutical Co Ltd 4.64%

Ascletis Pharma Inc 4.39%

Hanmi Pharm Co Ltd 4.33%

Zealand Pharma A/S 3.94%

Roche Holding AG 3.10%

Only in WDNA

TWIST BIOSCIENCE CORP 5.96%

MODERNA INC 4.15%

JOHNSON & JOHNSON 2.97%

UNITED THERAPEUTICS CORP 2.45%

NATERA INC 2.33%

TEMPUS AI INC 2.29%

IMMUNOME INC 2.26%

STOKE THERAPEUTICS INC 2.10%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

13% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	OZEM	WDNA	OZEM	WDNA	OZEM	WDNA
3 months	−4.9%	+16.6%	−7.5 pts	+14.1 pts	−7.1 pts	+14.5 pts
6 months	−3.5%	+36.5%	−20.5 pts	+19.5 pts	−30.4 pts	+9.6 pts
1 year	+14.0%	+58.6%	−1.7 pts	+42.9 pts	−9.8 pts	+34.8 pts
3 years	not published	+69.0%	not published	−16.0 pts	not published	−41.0 pts
Since launch OZEM May 2024 · WDNA Jun 2021	+23.1%	+2.8%	−24.7 pts	−93.2 pts	−41.3 pts	−128.7 pts

OZEM and WDNA over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

OZEM

Roundhill GLP-1 & Weight Loss ETF · Holds 26 stocks in healthcare innovation and GLP-1, 27% of its weight in S&P 500 companies

WDNA

WisdomTree BioRevolution Fund · Holds 80 stocks in healthcare innovation and GLP-1, 26% of its weight in S&P 500 companies

Issuer Roundhill WisdomTree

Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1

In the S&P 500 26.6% 25.9%

Active share vs the S&P 500 97.8% 95.3%

In the Nasdaq-100 6.2% 5.8%

Holdings 26 80

Top ten, share of the fund 66.4% 30.7%

Expense ratio 0.59% 0.45%

Fee for the differing part 0.60% 0.47%

Total return, 1 year +14.0% +58.6%

vs the S&P 500 −1.7 pts +42.9 pts

vs the Nasdaq-100 −9.8 pts +34.8 pts

Below its high −16.8% −8.1%

Net assets $58m $4m

OZEM and WDNA on the same fields, as of Sep 30, 2026. Source: ETFIQ.

OZEM in plain words

By weight, 27% of OZEM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 66% of the fund across 26 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +14.0% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 1.7 pts. It sits 16.8% below its all-time high of Jan 26, 2026.

WDNA in plain words

By weight, 26% of WDNA's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 31% of the fund across 80 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +58.6% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 42.9 pts. It sits 8.1% below its all-time high of Sep 2, 2021.

Questions people ask

Do OZEM and WDNA hold the same stocks?: By their latest filings, 13% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, OZEM or WDNA?: OZEM has 27% of its weight in S&P 500 names and WDNA has 26%, so OZEM differs more from the index.
Which is cheaper, OZEM or WDNA?: OZEM charges 0.59% a year and WDNA charges 0.45%, so WDNA is cheaper. Fees come from each fund's prospectus.

Other comparisons

OZEM vs THNR OZEM vs LGHT OZEM vs BMED OZEM vs EKG WDNA vs BMED WDNA vs EKG WDNA vs HEAL WDNA vs HELX

OZEM on its own →WDNA on its own →How every figure is computed →Standards and sources →

Where these figures came from

OZEM filings on SEC EDGAR ↗OZEM prospectus with the expense ratio (SEC) ↗Roundhill page for OZEM ↗WDNA filings on SEC EDGAR ↗WDNA prospectus with the expense ratio (SEC) ↗WisdomTree page for WDNA ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, OZEM against WDNA, data as of Sep 30, 2026. https://etfiq.com/compare/themes/ozem-vs-wdna

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.