Do EKG and WDNA hold the same stocks?

By their latest filings, 11% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, EKG or WDNA?

EKG has 39% of its weight in S&P 500 names and WDNA has 26%, so EKG differs more from the index.

Which is cheaper, EKG or WDNA?

EKG charges 0.65% a year and WDNA charges 0.45%, so WDNA is cheaper. Fees come from each fund's prospectus.

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EKG vs WDNA: which is really different?

EKG and WDNA hold 11% of their weight in the same names, and WDNA returned +58.6% over the year. First Trust Nasdaq Lux Digital Health Solutions ETF and WisdomTree BioRevolution Fund.

39.0%

EKG in the S&P 500

25.9%

WDNA in the S&P 500

+36.5%

EKG total return, 1 year

+58.6%

WDNA total return, 1 year

EKG · 1 year to Sep 30, 202661% of its weight is outside the S&P 500

39% of EKG's weight is in S&P 500 companies and 61% is outside the index

WDNA · 1 year to Sep 30, 202674% of its weight is outside the S&P 500

26% of WDNA's weight is in S&P 500 companies and 74% is outside the index

ETFIQ Off-Index Score · EKG scores higherHow much of it is not the index it is sold as an alternative to?

EKG 71.7

WDNA 34

0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, EKG and WDNA hold 11% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and Sep 30, 2026.

50%

half

11% in common

Positions both hold, largest shared weight first

Holding EKG WDNA

Twist Bioscience Corporation 2.87% 5.96%

Natera, Inc. 9.54% 2.33%

Tempus AI, Inc. (Class A) 3.22% 2.29%

10X Genomics, Inc. (Class A) 2.44% 1.81%

Veracyte, Inc. 0.80% 1.46%

Illumina, Inc. 4.76% 0.54%

QIAGEN N.V. 3.05% 0.25%

Only in EKG

Intuitive Surgical, Inc. 8.03%

IQVIA Holdings Inc. 7.65%

Veeva Systems Inc. (Class A) 7.43%

DexCom, Inc. 7.05%

Guardant Health, Inc. 4.17%

ResMed Inc. 3.42%

Globus Medical, Inc. (Class A) 3.17%

Align Technology, Inc. 2.70%

Only in WDNA

MODERNA INC 4.15%

ELI LILLY & COMPANY 4.08%

JOHNSON & JOHNSON 2.97%

UNITED THERAPEUTICS CORP 2.45%

IMMUNOME INC 2.26%

STRUCTURE THERAPEUTICS INC 2.12%

STOKE THERAPEUTICS INC 2.10%

BEAM THERAPEUTICS INC 2.09%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

11% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	EKG	WDNA	EKG	WDNA	EKG	WDNA
3 months	+21.3%	+16.6%	+18.8 pts	+14.1 pts	+19.1 pts	+14.5 pts
6 months	+45.4%	+36.5%	+28.5 pts	+19.5 pts	+18.6 pts	+9.6 pts
1 year	+36.5%	+58.6%	+20.8 pts	+42.9 pts	+12.7 pts	+34.8 pts
3 years	+68.7%	+69.0%	−16.3 pts	−16.0 pts	−41.3 pts	−41.0 pts
Since launch EKG Mar 2022 · WDNA Jun 2021	+19.7%	+2.8%	−62.9 pts	−93.2 pts	−96.4 pts	−128.7 pts

EKG and WDNA over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

EKG

First Trust Nasdaq Lux Digital Health Solutions ETF · Holds 52 stocks in healthcare innovation and GLP-1, 39% of its weight in S&P 500 companies

WDNA

WisdomTree BioRevolution Fund · Holds 80 stocks in healthcare innovation and GLP-1, 26% of its weight in S&P 500 companies

Issuer First Trust WisdomTree

Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1

In the S&P 500 39.0% 25.9%

Active share vs the S&P 500 99.6% 95.3%

In the Nasdaq-100 15.1% 5.8%

Holdings 52 80

Top ten, share of the fund 58.4% 30.7%

Expense ratio 0.65% 0.45%

Fee for the differing part 0.65% 0.47%

Total return, 1 year +36.5% +58.6%

vs the S&P 500 +20.8 pts +42.9 pts

vs the Nasdaq-100 +12.7 pts +34.8 pts

Below its high 0.0% −8.1%

Net assets $5m $4m

EKG and WDNA on the same fields, as of Sep 30, 2026. Source: ETFIQ.

EKG in plain words

By weight, 39% of EKG's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 58% of the fund across 52 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +36.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 20.8 pts.

WDNA in plain words

By weight, 26% of WDNA's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 31% of the fund across 80 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +58.6% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 42.9 pts. It sits 8.1% below its all-time high of Sep 2, 2021.

Questions people ask

Do EKG and WDNA hold the same stocks?: By their latest filings, 11% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, EKG or WDNA?: EKG has 39% of its weight in S&P 500 names and WDNA has 26%, so EKG differs more from the index.
Which is cheaper, EKG or WDNA?: EKG charges 0.65% a year and WDNA charges 0.45%, so WDNA is cheaper. Fees come from each fund's prospectus.

Other comparisons

EKG vs THNR EKG vs LGHT EKG vs OZEM EKG vs BMED WDNA vs HEAL WDNA vs HELX WDNA vs LGHT WDNA vs OZEM

EKG on its own →WDNA on its own →How every figure is computed →Standards and sources →

Where these figures came from

EKG filings on SEC EDGAR ↗EKG prospectus with the expense ratio (SEC) ↗First Trust page for EKG ↗WDNA filings on SEC EDGAR ↗WDNA prospectus with the expense ratio (SEC) ↗WisdomTree page for WDNA ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, EKG against WDNA, data as of Sep 30, 2026. https://etfiq.com/compare/themes/ekg-vs-wdna

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.