HELX vs WDNA: which is really different?

HELX and WDNA hold 34% of their weight in the same names, and WDNA returned +58.6% over the year. Franklin Genomic Advancements ETF and WisdomTree BioRevolution Fund.

15.1%
HELX in the S&P 500
25.9%
WDNA in the S&P 500
+44.5%
HELX total return, 1 year
+58.6%
WDNA total return, 1 year
HELX · 1 year to Sep 30, 202685% of its weight is outside the S&P 500
85% of its weight is outside the S&P 50015% of HELX's weight is in S&P 500 companies and 85% is outside the index15%85%in the S&P 500of its weight outside the S&P 500active share 97% · top ten 48% of the fund · 61 holdings filed Jun 30, 2026 · Nasdaq-100: 10% in85% of its weight is outside the S&P 50015% of HELX's weight is in S&P 500 companies and 85% is outside the index15%85%inof its weight outside the S&P 500active share 97% · top ten 48% of the fund

15% of HELX's weight is in S&P 500 companies and 85% is outside the index

WDNA · 1 year to Sep 30, 202674% of its weight is outside the S&P 500
74% of its weight is outside the S&P 50026% of WDNA's weight is in S&P 500 companies and 74% is outside the index26%74%in the S&P 500of its weight outside the S&P 500active share 95% · top ten 31% of the fund · 80 holdings filed Jun 30, 2026 · Nasdaq-100: 6% in74% of its weight is outside the S&P 50026% of WDNA's weight is in S&P 500 companies and 74% is outside the index26%74%inoutside the S&P 500active share 95% · top ten 31% of the fund

26% of WDNA's weight is in S&P 500 companies and 74% is outside the index

ETFIQ Off-Index Score · HELX scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, HELX and WDNA hold 34% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026.

half

34% in common

Positions both hold, largest shared weight first
Holding HELX WDNA
ELI LILLY & COMPANY 2.99% 4.08%
TWIST BIOSCIENCE CORP 2.89% 5.96%
UNITED THERAPEUTICS CORP 3.55% 2.45%
NATERA INC 7.56% 2.33%
CORTEVA INC 2.28% 1.99%
TEMPUS AI INC 1.97% 2.29%
KRYSTAL BIOTECH INC 6.41% 1.96%
IONIS PHARMACEUTICALS INC 1.94% 1.86%
ASTRAZENECA PLC 2.74% 1.83%
VERACYTE INC 1.67% 1.46%
STOKE THERAPEUTICS INC 1.35% 2.10%
VERTEX PHARMACEUTICALS INC 2.78% 1.34%
Only in HELX
GUARDANT HEALTH INC 9.21%
LIGAND PHARMACEUTICALS INC 4.68%
ADAPTIVE BIOTECHNOLOGIES CORP 4.04%
TRAVERE THERAPEUTICS INC 2.63%
SAMSUNG BIOLOGICS CO LTD 2.29%
MEDPACE HOLDINGS INC 2.17%
NEUROCRINE BIOSCIENCES INC 1.87%
PTC THERAPEUTICS INC 1.48%
Only in WDNA
MODERNA INC 4.15%
JOHNSON & JOHNSON 2.97%
IMMUNOME INC 2.26%
STRUCTURE THERAPEUTICS INC 2.12%
DARLING INGREDIENTS INC 1.94%
10X GENOMICS INC 1.81%
ROIVANT SCIENCES LTD 1.73%
ABSCI CORP 1.71%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

34% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowHELXWDNAHELXWDNAHELXWDNA
3 months+9.9%+16.6%+7.4 pts+14.1 pts+7.8 pts+14.5 pts
6 months+33.6%+36.5%+16.6 pts+19.5 pts+6.8 pts+9.6 pts
1 year+44.5%+58.6%+28.8 pts+42.9 pts+20.8 pts+34.8 pts
3 years+57.9%+69.0%−27.1 pts−16.0 pts−52.1 pts−41.0 pts
Since launch
HELX Feb 2020 · WDNA Jun 2021
+87.4%+2.8%−94.7 pts−93.2 pts−187.2 pts−128.7 pts

HELX and WDNA over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

HELX
Franklin Genomic Advancements ETF · Holds 61 stocks in healthcare innovation and GLP-1, 15% of its weight in S&P 500 companies
WDNA
WisdomTree BioRevolution Fund · Holds 80 stocks in healthcare innovation and GLP-1, 26% of its weight in S&P 500 companies
Issuer Franklin WisdomTree
Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1
In the S&P 500 15.1% 25.9%
Active share vs the S&P 500 97.2% 95.3%
In the Nasdaq-100 10.0% 5.8%
Holdings 61 80
Top ten, share of the fund 47.7% 30.7%
Expense ratio 0.50% 0.45%
Fee for the differing part 0.51% 0.47%
Total return, 1 year +44.5% +58.6%
vs the S&P 500 +28.8 pts +42.9 pts
vs the Nasdaq-100 +20.8 pts +34.8 pts
Below its high −23.0% −8.1%
Net assets $33m $4m

HELX and WDNA on the same fields, as of Sep 30, 2026. Source: ETFIQ.

HELX in plain words

By weight, 15% of HELX's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 48% of the fund across 61 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +44.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 28.8 pts. It sits 23.0% below its all-time high of Sep 7, 2021.

WDNA in plain words

By weight, 26% of WDNA's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 31% of the fund across 80 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +58.6% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 42.9 pts. It sits 8.1% below its all-time high of Sep 2, 2021.

Questions people ask

Do HELX and WDNA hold the same stocks?
By their latest filings, 34% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, HELX or WDNA?
HELX has 15% of its weight in S&P 500 names and WDNA has 26%, so HELX differs more from the index.
Which is cheaper, HELX or WDNA?
HELX charges 0.50% a year and WDNA charges 0.45%, so WDNA is cheaper. Fees come from each fund's prospectus.
Cite this page

ETFIQ, HELX against WDNA, data as of Sep 30, 2026. https://etfiq.com/compare/themes/helx-vs-wdna

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.