Do HELX and OZEM hold the same stocks?

By their latest filings, 6% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, HELX or OZEM?

HELX has 15% of its weight in S&P 500 names and OZEM has 27%, so OZEM differs more from the index.

Which is cheaper, HELX or OZEM?

HELX charges 0.50% a year and OZEM charges 0.59%, so HELX is cheaper. Fees come from each fund's prospectus.

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HELX vs OZEM: which is really different?

HELX and OZEM hold 6% of their weight in the same names, and HELX returned +44.5% over the year. Franklin Genomic Advancements ETF and Roundhill GLP-1 & Weight Loss ETF.

15.1%

HELX in the S&P 500

26.6%

OZEM in the S&P 500

+44.5%

HELX total return, 1 year

+14.0%

OZEM total return, 1 year

HELX · 1 year to Sep 30, 202685% of its weight is outside the S&P 500

15% of HELX's weight is in S&P 500 companies and 85% is outside the index

OZEM · 1 year to Sep 30, 202673% of its weight is outside the S&P 500

27% of OZEM's weight is in S&P 500 companies and 73% is outside the index

ETFIQ Off-Index Score · OZEM scores higherHow much of it is not the index it is sold as an alternative to?

HELX 41.3

OZEM 46.9

0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, HELX and OZEM hold 6% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and Sep 30, 2026.

50%

half

6% in common

Positions both hold, largest shared weight first

Holding HELX OZEM

ELI LILLY & COMPANY 2.99% 12.69%

ASTRAZENECA PLC 2.74% 3.79%

RHYTHM PHARMACEUTICALS INC 0.42% 1.47%

WAVE LIFE SCIENCES LTD 0.10% 0.29%

Only in HELX

GUARDANT HEALTH INC 9.21%

NATERA INC 7.56%

KRYSTAL BIOTECH INC 6.41%

LIGAND PHARMACEUTICALS INC 4.68%

ADAPTIVE BIOTECHNOLOGIES CORP 4.04%

UNITED THERAPEUTICS CORP 3.55%

BRIDGEBIO PHARMA INC 3.54%

TWIST BIOSCIENCE CORP 2.89%

Only in OZEM

Novo Nordisk A/S 11.09%

Pfizer Inc 7.69%

CSPC Pharmaceutical Group Ltd 6.52%

Viking Therapeutics Inc 5.47%

Kailera Therapeutics Inc 5.17%

Chugai Pharmaceutical Co Ltd 4.64%

Ascletis Pharma Inc 4.39%

Amgen Inc 4.37%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

6% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	HELX	OZEM	HELX	OZEM	HELX	OZEM
3 months	+9.9%	−4.9%	+7.4 pts	−7.5 pts	+7.8 pts	−7.1 pts
6 months	+33.6%	−3.5%	+16.6 pts	−20.5 pts	+6.8 pts	−30.4 pts
1 year	+44.5%	+14.0%	+28.8 pts	−1.7 pts	+20.8 pts	−9.8 pts
3 years	+57.9%	not published	−27.1 pts	not published	−52.1 pts	not published
Since launch HELX Feb 2020 · OZEM May 2024	+87.4%	+23.1%	−94.7 pts	−24.7 pts	−187.2 pts	−41.3 pts

HELX and OZEM over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

HELX

Franklin Genomic Advancements ETF · Holds 61 stocks in healthcare innovation and GLP-1, 15% of its weight in S&P 500 companies

OZEM

Roundhill GLP-1 & Weight Loss ETF · Holds 26 stocks in healthcare innovation and GLP-1, 27% of its weight in S&P 500 companies

Issuer Franklin Roundhill

Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1

In the S&P 500 15.1% 26.6%

Active share vs the S&P 500 97.2% 97.8%

In the Nasdaq-100 10.0% 6.2%

Holdings 61 26

Top ten, share of the fund 47.7% 66.4%

Expense ratio 0.50% 0.59%

Fee for the differing part 0.51% 0.60%

Total return, 1 year +44.5% +14.0%

vs the S&P 500 +28.8 pts −1.7 pts

vs the Nasdaq-100 +20.8 pts −9.8 pts

Below its high −23.0% −16.8%

Net assets $33m $58m

HELX and OZEM on the same fields, as of Sep 30, 2026. Source: ETFIQ.

HELX in plain words

By weight, 15% of HELX's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 48% of the fund across 61 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +44.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 28.8 pts. It sits 23.0% below its all-time high of Sep 7, 2021.

OZEM in plain words

By weight, 27% of OZEM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 66% of the fund across 26 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +14.0% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 1.7 pts. It sits 16.8% below its all-time high of Jan 26, 2026.

Questions people ask

Do HELX and OZEM hold the same stocks?: By their latest filings, 6% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, HELX or OZEM?: HELX has 15% of its weight in S&P 500 names and OZEM has 27%, so OZEM differs more from the index.
Which is cheaper, HELX or OZEM?: HELX charges 0.50% a year and OZEM charges 0.59%, so HELX is cheaper. Fees come from each fund's prospectus.

Other comparisons

HELX vs LGHT HELX vs BMED HELX vs WDNA HELX vs EKG OZEM vs THNR OZEM vs WDNA OZEM vs BMED OZEM vs EKG

HELX on its own →OZEM on its own →How every figure is computed →Standards and sources →

Where these figures came from

HELX filings on SEC EDGAR ↗HELX prospectus with the expense ratio (SEC) ↗Franklin website ↗OZEM filings on SEC EDGAR ↗OZEM prospectus with the expense ratio (SEC) ↗Roundhill page for OZEM ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, HELX against OZEM, data as of Sep 30, 2026. https://etfiq.com/compare/themes/helx-vs-ozem

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.