Do EKG and OZEM hold the same stocks?

By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, EKG or OZEM?

EKG has 39% of its weight in S&P 500 names and OZEM has 27%, so EKG differs more from the index.

Which is cheaper, EKG or OZEM?

EKG charges 0.65% a year and OZEM charges 0.59%, so OZEM is cheaper. Fees come from each fund's prospectus.

Share on X Download as PDF Open live

EKG vs OZEM: which is really different?

EKG and OZEM hold 0% of their weight in the same names, and EKG returned +36.5% over the year. First Trust Nasdaq Lux Digital Health Solutions ETF and Roundhill GLP-1 & Weight Loss ETF.

39.0%

EKG in the S&P 500

26.6%

OZEM in the S&P 500

+36.5%

EKG total return, 1 year

+14.0%

OZEM total return, 1 year

EKG · 1 year to Sep 30, 202661% of its weight is outside the S&P 500

39% of EKG's weight is in S&P 500 companies and 61% is outside the index

OZEM · 1 year to Sep 30, 202673% of its weight is outside the S&P 500

27% of OZEM's weight is in S&P 500 companies and 73% is outside the index

ETFIQ Off-Index Score · EKG scores higherHow much of it is not the index it is sold as an alternative to?

EKG 71.7

OZEM 46.9

0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, EKG and OZEM hold 0% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 30, 2026.

50%

half

0% in common

Positions both hold, largest shared weight first

Holding EKG OZEM

Only in EKG

Natera, Inc. 9.54%

Intuitive Surgical, Inc. 8.03%

IQVIA Holdings Inc. 7.65%

Veeva Systems Inc. (Class A) 7.43%

DexCom, Inc. 7.05%

Illumina, Inc. 4.76%

Guardant Health, Inc. 4.17%

ResMed Inc. 3.42%

Only in OZEM

Eli Lilly & Co 12.69%

Novo Nordisk A/S 11.09%

Pfizer Inc 7.69%

CSPC Pharmaceutical Group Ltd 6.52%

Viking Therapeutics Inc 5.47%

Kailera Therapeutics Inc 5.17%

Chugai Pharmaceutical Co Ltd 4.64%

Ascletis Pharma Inc 4.39%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

0% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	EKG	OZEM	EKG	OZEM	EKG	OZEM
3 months	+21.3%	−4.9%	+18.8 pts	−7.5 pts	+19.1 pts	−7.1 pts
6 months	+45.4%	−3.5%	+28.5 pts	−20.5 pts	+18.6 pts	−30.4 pts
1 year	+36.5%	+14.0%	+20.8 pts	−1.7 pts	+12.7 pts	−9.8 pts
3 years	+68.7%	not published	−16.3 pts	not published	−41.3 pts	not published
Since launch EKG Mar 2022 · OZEM May 2024	+19.7%	+23.1%	−62.9 pts	−24.7 pts	−96.4 pts	−41.3 pts

EKG and OZEM over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

EKG

First Trust Nasdaq Lux Digital Health Solutions ETF · Holds 52 stocks in healthcare innovation and GLP-1, 39% of its weight in S&P 500 companies

OZEM

Roundhill GLP-1 & Weight Loss ETF · Holds 26 stocks in healthcare innovation and GLP-1, 27% of its weight in S&P 500 companies

Issuer First Trust Roundhill

Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1

In the S&P 500 39.0% 26.6%

Active share vs the S&P 500 99.6% 97.8%

In the Nasdaq-100 15.1% 6.2%

Holdings 52 26

Top ten, share of the fund 58.4% 66.4%

Expense ratio 0.65% 0.59%

Fee for the differing part 0.65% 0.60%

Total return, 1 year +36.5% +14.0%

vs the S&P 500 +20.8 pts −1.7 pts

vs the Nasdaq-100 +12.7 pts −9.8 pts

Below its high 0.0% −16.8%

Net assets $5m $58m

EKG and OZEM on the same fields, as of Sep 30, 2026. Source: ETFIQ.

EKG in plain words

By weight, 39% of EKG's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 58% of the fund across 52 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +36.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 20.8 pts.

OZEM in plain words

By weight, 27% of OZEM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 66% of the fund across 26 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +14.0% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 1.7 pts. It sits 16.8% below its all-time high of Jan 26, 2026.

Questions people ask

Do EKG and OZEM hold the same stocks?: By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, EKG or OZEM?: EKG has 39% of its weight in S&P 500 names and OZEM has 27%, so EKG differs more from the index.
Which is cheaper, EKG or OZEM?: EKG charges 0.65% a year and OZEM charges 0.59%, so OZEM is cheaper. Fees come from each fund's prospectus.

Other comparisons

EKG vs HEAL EKG vs HELX EKG vs LGHT EKG vs THNR OZEM vs THNR OZEM vs WDNA OZEM vs LGHT OZEM vs HEAL

EKG on its own →OZEM on its own →How every figure is computed →Standards and sources →

Where these figures came from

EKG filings on SEC EDGAR ↗EKG prospectus with the expense ratio (SEC) ↗First Trust page for EKG ↗OZEM filings on SEC EDGAR ↗OZEM prospectus with the expense ratio (SEC) ↗Roundhill page for OZEM ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, EKG against OZEM, data as of Sep 30, 2026. https://etfiq.com/compare/themes/ekg-vs-ozem

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.