Do EKG and HELX hold the same stocks?

By their latest filings, 23% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, EKG or HELX?

EKG has 39% of its weight in S&P 500 names and HELX has 15%, so EKG differs more from the index.

Which is cheaper, EKG or HELX?

EKG charges 0.65% a year and HELX charges 0.50%, so HELX is cheaper. Fees come from each fund's prospectus.

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EKG vs HELX: which is really different?

EKG and HELX hold 23% of their weight in the same names, and HELX returned +44.5% over the year. First Trust Nasdaq Lux Digital Health Solutions ETF and Franklin Genomic Advancements ETF.

39.0%

EKG in the S&P 500

15.1%

HELX in the S&P 500

+36.5%

EKG total return, 1 year

+44.5%

HELX total return, 1 year

EKG · 1 year to Sep 30, 202661% of its weight is outside the S&P 500

39% of EKG's weight is in S&P 500 companies and 61% is outside the index

HELX · 1 year to Sep 30, 202685% of its weight is outside the S&P 500

15% of HELX's weight is in S&P 500 companies and 85% is outside the index

ETFIQ Off-Index Score · EKG scores higherHow much of it is not the index it is sold as an alternative to?

EKG 71.7

HELX 41.3

0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, EKG and HELX hold 23% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and Sep 30, 2026.

50%

half

23% in common

Positions both hold, largest shared weight first

Holding EKG HELX

Natera, Inc. 9.54% 7.56%

Guardant Health, Inc. 4.17% 9.21%

Twist Bioscience Corporation 2.87% 2.89%

Tempus AI, Inc. (Class A) 3.22% 1.97%

Adaptive Biotechnologies Corporation 1.44% 4.04%

GRAIL, Inc. 1.98% 1.10%

CareDx, Inc. 1.05% 0.83%

Veracyte, Inc. 0.80% 1.67%

IQVIA Holdings Inc. 7.65% 0.76%

Hinge Health, Inc. (Class A) 2.07% 0.71%

QIAGEN N.V. 3.05% 0.48%

GeneDx Holdings Corp. 0.65% 0.14%

Only in EKG

Intuitive Surgical, Inc. 8.03%

Veeva Systems Inc. (Class A) 7.43%

DexCom, Inc. 7.05%

Illumina, Inc. 4.76%

ResMed Inc. 3.42%

Globus Medical, Inc. (Class A) 3.17%

Align Technology, Inc. 2.70%

Oscar Health, Inc. (Class A) 2.69%

Only in HELX

KRYSTAL BIOTECH INC 6.41%

LIGAND PHARMACEUTICALS INC 4.68%

UNITED THERAPEUTICS CORP 3.55%

BRIDGEBIO PHARMA INC 3.54%

ELI LILLY & COMPANY 2.99%

VERTEX PHARMACEUTICALS INC 2.78%

ASTRAZENECA PLC 2.74%

TRAVERE THERAPEUTICS INC 2.63%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

23% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	EKG	HELX	EKG	HELX	EKG	HELX
3 months	+21.3%	+9.9%	+18.8 pts	+7.4 pts	+19.1 pts	+7.8 pts
6 months	+45.4%	+33.6%	+28.5 pts	+16.6 pts	+18.6 pts	+6.8 pts
1 year	+36.5%	+44.5%	+20.8 pts	+28.8 pts	+12.7 pts	+20.8 pts
3 years	+68.7%	+57.9%	−16.3 pts	−27.1 pts	−41.3 pts	−52.1 pts
Since launch EKG Mar 2022 · HELX Feb 2020	+19.7%	+87.4%	−62.9 pts	−94.7 pts	−96.4 pts	−187.2 pts

EKG and HELX over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

EKG

First Trust Nasdaq Lux Digital Health Solutions ETF · Holds 52 stocks in healthcare innovation and GLP-1, 39% of its weight in S&P 500 companies

HELX

Franklin Genomic Advancements ETF · Holds 61 stocks in healthcare innovation and GLP-1, 15% of its weight in S&P 500 companies

Issuer First Trust Franklin

Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1

In the S&P 500 39.0% 15.1%

Active share vs the S&P 500 99.6% 97.2%

In the Nasdaq-100 15.1% 10.0%

Holdings 52 61

Top ten, share of the fund 58.4% 47.7%

Expense ratio 0.65% 0.50%

Fee for the differing part 0.65% 0.51%

Total return, 1 year +36.5% +44.5%

vs the S&P 500 +20.8 pts +28.8 pts

vs the Nasdaq-100 +12.7 pts +20.8 pts

Below its high 0.0% −23.0%

Net assets $5m $33m

EKG and HELX on the same fields, as of Sep 30, 2026. Source: ETFIQ.

EKG in plain words

By weight, 39% of EKG's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 58% of the fund across 52 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +36.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 20.8 pts.

HELX in plain words

By weight, 15% of HELX's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 48% of the fund across 61 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +44.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 28.8 pts. It sits 23.0% below its all-time high of Sep 7, 2021.

Questions people ask

Do EKG and HELX hold the same stocks?: By their latest filings, 23% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, EKG or HELX?: EKG has 39% of its weight in S&P 500 names and HELX has 15%, so EKG differs more from the index.
Which is cheaper, EKG or HELX?: EKG charges 0.65% a year and HELX charges 0.50%, so HELX is cheaper. Fees come from each fund's prospectus.

Other comparisons

EKG vs HEAL EKG vs THNR EKG vs WDNA EKG vs LGHT HELX vs LGHT HELX vs OZEM HELX vs THNR HELX vs WDNA

EKG on its own →HELX on its own →How every figure is computed →Standards and sources →

Where these figures came from

EKG filings on SEC EDGAR ↗EKG prospectus with the expense ratio (SEC) ↗First Trust page for EKG ↗HELX filings on SEC EDGAR ↗HELX prospectus with the expense ratio (SEC) ↗Franklin website ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, EKG against HELX, data as of Sep 30, 2026. https://etfiq.com/compare/themes/ekg-vs-helx

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.