Do HELX and THNR hold the same stocks?

By their latest filings, 8% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, HELX or THNR?

HELX has 15% of its weight in S&P 500 names and THNR has 40%, so HELX differs more from the index.

Which is cheaper, HELX or THNR?

HELX charges 0.50% a year and THNR charges 0.59%, so HELX is cheaper. Fees come from each fund's prospectus.

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HELX vs THNR: which is really different?

HELX and THNR hold 8% of their weight in the same names, and HELX returned +44.5% over the year. Franklin Genomic Advancements ETF and Amplify Weight Loss Drug & Treatment ETF.

15.1%

HELX in the S&P 500

39.5%

THNR in the S&P 500

+44.5%

HELX total return, 1 year

+9.2%

THNR total return, 1 year

HELX · 1 year to Sep 30, 202685% of its weight is outside the S&P 500

15% of HELX's weight is in S&P 500 companies and 85% is outside the index

THNR · 1 year to Sep 30, 202661% of its weight is outside the S&P 500

40% of THNR's weight is in S&P 500 companies and 61% is outside the index

ETFIQ Off-Index Score · HELX scores higherHow much of it is not the index it is sold as an alternative to?

HELX 41.3

THNR 37.7

0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, HELX and THNR hold 8% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and Oct 1, 2026.

50%

half

8% in common

Positions both hold, largest shared weight first

Holding HELX THNR

ELI LILLY & COMPANY 2.99% 10.07%

ASTRAZENECA PLC 2.74% 5.27%

REGENERON PHARMACEUTICALS INC 1.82% 4.64%

Only in HELX

GUARDANT HEALTH INC 9.21%

NATERA INC 7.56%

KRYSTAL BIOTECH INC 6.41%

LIGAND PHARMACEUTICALS INC 4.68%

ADAPTIVE BIOTECHNOLOGIES CORP 4.04%

UNITED THERAPEUTICS CORP 3.55%

BRIDGEBIO PHARMA INC 3.54%

TWIST BIOSCIENCE CORP 2.89%

Only in THNR

Novo Nordisk A/S 8.42%

CSPC Pharmaceutical Group Ltd 5.82%

Amgen Inc 5.75%

Pfizer Inc 5.38%

Innovent Biologics Inc 5.30%

AbbVie Inc 4.56%

Roche Holding AG 4.56%

Gilead Sciences Inc 4.55%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

8% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	HELX	THNR	HELX	THNR	HELX	THNR
3 months	+9.9%	−1.8%	+7.4 pts	−4.3 pts	+7.8 pts	−3.9 pts
6 months	+33.6%	+0.7%	+16.6 pts	−16.3 pts	+6.8 pts	−26.1 pts
1 year	+44.5%	+9.2%	+28.8 pts	−6.5 pts	+20.8 pts	−14.6 pts
3 years	+57.9%	not published	−27.1 pts	not published	−52.1 pts	not published
Since launch HELX Feb 2020 · THNR May 2024	+87.4%	+1.6%	−94.7 pts	−46.1 pts	−187.2 pts	−62.8 pts

HELX and THNR over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

HELX

Franklin Genomic Advancements ETF · Holds 61 stocks in healthcare innovation and GLP-1, 15% of its weight in S&P 500 companies

THNR

Amplify Weight Loss Drug & Treatment ETF · Holds 22 stocks in healthcare innovation and GLP-1, 40% of its weight in S&P 500 companies

Issuer Franklin Amplify

Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1

In the S&P 500 15.1% 39.5%

Active share vs the S&P 500 97.2% 96.5%

In the Nasdaq-100 10.0% 14.9%

Holdings 61 22

Top ten, share of the fund 47.7% 59.8%

Expense ratio 0.50% 0.59%

Fee for the differing part 0.51% 0.61%

Total return, 1 year +44.5% +9.2%

vs the S&P 500 +28.8 pts −6.5 pts

vs the Nasdaq-100 +20.8 pts −14.6 pts

Below its high −23.0% −9.9%

Net assets $33m $6m

HELX and THNR on the same fields, as of Sep 30, 2026. Source: ETFIQ.

HELX in plain words

By weight, 15% of HELX's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 48% of the fund across 61 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +44.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 28.8 pts. It sits 23.0% below its all-time high of Sep 7, 2021.

THNR in plain words

By weight, 40% of THNR's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 96%. The top ten holdings are 60% of the fund across 22 positions, as published by its issuer for Oct 1, 2026. Over the year to Sep 30, 2026 the fund returned +9.2% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 6.5 pts. It sits 9.9% below its all-time high of Aug 25, 2026.

Questions people ask

Do HELX and THNR hold the same stocks?: By their latest filings, 8% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, HELX or THNR?: HELX has 15% of its weight in S&P 500 names and THNR has 40%, so HELX differs more from the index.
Which is cheaper, HELX or THNR?: HELX charges 0.50% a year and THNR charges 0.59%, so HELX is cheaper. Fees come from each fund's prospectus.

Other comparisons

HELX vs LGHT HELX vs OZEM HELX vs BMED HELX vs EKG THNR vs WDNA THNR vs BMED THNR vs EKG THNR vs LGHT

HELX on its own →THNR on its own →How every figure is computed →Standards and sources →

Where these figures came from

HELX filings on SEC EDGAR ↗HELX prospectus with the expense ratio (SEC) ↗Franklin website ↗THNR filings on SEC EDGAR ↗THNR prospectus with the expense ratio (SEC) ↗Amplify page for THNR ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, HELX against THNR, data as of Sep 30, 2026. https://etfiq.com/compare/themes/helx-vs-thnr

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.