ETFIQ
RankingsCompareHoldingsResearch
My portfolioWeekly note
A
vs
B
Share on XDownload as PDFOpen live

EKG vs THNR: which is really different?

EKG and THNR hold 0% of their weight in the same names, and EKG returned +36.5% over the year. First Trust Nasdaq Lux Digital Health Solutions ETF and Amplify Weight Loss Drug & Treatment ETF.

39.0%
EKG in the S&P 500
39.5%
THNR in the S&P 500
+36.5%
EKG total return, 1 year
+9.2%
THNR total return, 1 year
EKG · 1 year to Sep 30, 202661% of its weight is outside the S&P 500
61% of its weight is outside the S&P 50039% of EKG's weight is in S&P 500 companies and 61% is outside the index39%61%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 58% of the fund · 52 holdings filed Sep 30, 2026 · Nasdaq-100: 15% in61% of its weight is outside the S&P 50039% of EKG's weight is in S&P 500 companies and 61% is outside the index39%61%in the S&P 500outside the S&P 500active share 100% · top ten 58% of the fund

39% of EKG's weight is in S&P 500 companies and 61% is outside the index

THNR · 1 year to Sep 30, 202661% of its weight is outside the S&P 500
61% of its weight is outside the S&P 50040% of THNR's weight is in S&P 500 companies and 61% is outside the index40%61%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 97% · top ten 60% of the fund · 22 holdings filed Oct 1, 2026 · Nasdaq-100: 15% in61% of its weight is outside the S&P 50040% of THNR's weight is in S&P 500 companies and 61% is outside the index40%61%in the S&P 500outside the S&P 500active share 97% · top ten 60% of the fund

40% of THNR's weight is in S&P 500 companies and 61% is outside the index

ETFIQ Off-Index Score · EKG scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, EKG and THNR hold 0% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Oct 1, 2026 and Sep 30, 2026.

half

0% in common

Positions both hold, largest shared weight first
Holding EKG THNR
Only in EKG
Natera, Inc. 9.54%
Intuitive Surgical, Inc. 8.03%
IQVIA Holdings Inc. 7.65%
Veeva Systems Inc. (Class A) 7.43%
DexCom, Inc. 7.05%
Illumina, Inc. 4.76%
Guardant Health, Inc. 4.17%
ResMed Inc. 3.42%
Only in THNR
Eli Lilly & Co 10.07%
Novo Nordisk A/S 8.42%
CSPC Pharmaceutical Group Ltd 5.82%
Amgen Inc 5.75%
Pfizer Inc 5.38%
Innovent Biologics Inc 5.30%
AstraZeneca PLC 5.27%
Regeneron Pharmaceuticals Inc 4.64%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

0% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowEKGTHNREKGTHNREKGTHNR
3 months+21.3%−1.8%+18.8 pts−4.3 pts+19.1 pts−3.9 pts
6 months+45.4%+0.7%+28.5 pts−16.3 pts+18.6 pts−26.1 pts
1 year+36.5%+9.2%+20.8 pts−6.5 pts+12.7 pts−14.6 pts
3 years+68.7%not published−16.3 ptsnot published−41.3 ptsnot published
Since launch
EKG Mar 2022 · THNR May 2024
+19.7%+1.6%−62.9 pts−46.1 pts−96.4 pts−62.8 pts

EKG and THNR over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

EKG
First Trust Nasdaq Lux Digital Health Solutions ETF · Holds 52 stocks in healthcare innovation and GLP-1, 39% of its weight in S&P 500 companies
THNR
Amplify Weight Loss Drug & Treatment ETF · Holds 22 stocks in healthcare innovation and GLP-1, 40% of its weight in S&P 500 companies
Issuer First Trust Amplify
Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1
In the S&P 500 39.0% 39.5%
Active share vs the S&P 500 99.6% 96.5%
In the Nasdaq-100 15.1% 14.9%
Holdings 52 22
Top ten, share of the fund 58.4% 59.8%
Expense ratio 0.65% 0.59%
Fee for the differing part 0.65% 0.61%
Total return, 1 year +36.5% +9.2%
vs the S&P 500 +20.8 pts −6.5 pts
vs the Nasdaq-100 +12.7 pts −14.6 pts
Below its high 0.0% −9.9%
Net assets $5m $6m

EKG and THNR on the same fields, as of Sep 30, 2026. Source: ETFIQ.

EKG in plain words

By weight, 39% of EKG's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 58% of the fund across 52 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +36.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 20.8 pts.

THNR in plain words

By weight, 40% of THNR's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 96%. The top ten holdings are 60% of the fund across 22 positions, as published by its issuer for Oct 1, 2026. Over the year to Sep 30, 2026 the fund returned +9.2% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 6.5 pts. It sits 9.9% below its all-time high of Aug 25, 2026.

Questions people ask

Do EKG and THNR hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, EKG or THNR?
EKG has 39% of its weight in S&P 500 names and THNR has 40%, so EKG differs more from the index.
Which is cheaper, EKG or THNR?
EKG charges 0.65% a year and THNR charges 0.59%, so THNR is cheaper. Fees come from each fund's prospectus.
Other comparisons
EKG vs HEALEKG vs HELXEKG vs LGHTEKG vs OZEMTHNR vs WDNATHNR vs HEALTHNR vs OZEMTHNR vs HELX
EKG on its own →THNR on its own →How every figure is computed →Standards and sources →
Where these figures came from
EKG filings on SEC EDGAR ↗EKG prospectus with the expense ratio (SEC) ↗First Trust page for EKG ↗THNR filings on SEC EDGAR ↗THNR prospectus with the expense ratio (SEC) ↗Amplify page for THNR ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, EKG against THNR, data as of Sep 30, 2026. https://etfiq.com/compare/themes/ekg-vs-thnr

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.