BMED vs OZEM: which is really different?

BMED and OZEM hold 6% of their weight in the same names, and BMED returned +29.3% over the year. iShares Health Innovation Active ETF and Roundhill GLP-1 & Weight Loss ETF.

61.5%
BMED in the S&P 500
26.6%
OZEM in the S&P 500
+29.3%
BMED total return, 1 year
+14.0%
OZEM total return, 1 year
BMED · 1 year to Sep 30, 202639% of its weight is outside the S&P 500
39% of its weight is outside the S&P 50062% of BMED's weight is in S&P 500 companies and 39% is outside the index62%39%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 96% · top ten 43% of the fund · 60 holdings filed Sep 30, 2026 · Nasdaq-100: 13% in39% of its weight is outside the S&P 50062% of BMED's weight is in S&P 500 companies and 39% is outside the index62%39%in the S&P 500outsideactive share 96% · top ten 43% of the fund

62% of BMED's weight is in S&P 500 companies and 39% is outside the index

OZEM · 1 year to Sep 30, 202673% of its weight is outside the S&P 500
73% of its weight is outside the S&P 50027% of OZEM's weight is in S&P 500 companies and 73% is outside the index27%73%in the S&P 500of its weight outside the S&P 500active share 98% · top ten 66% of the fund · 26 holdings filed Sep 30, 2026 · Nasdaq-100: 6% in73% of its weight is outside the S&P 50027% of OZEM's weight is in S&P 500 companies and 73% is outside the index27%73%inoutside the S&P 500active share 98% · top ten 66% of the fund

27% of OZEM's weight is in S&P 500 companies and 73% is outside the index

ETFIQ Off-Index Score · OZEM scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, BMED and OZEM hold 6% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 30, 2026.

half

6% in common

Positions both hold, largest shared weight first
Holding BMED OZEM
AMGEN INC 2.45% 4.37%
GILEAD SCIENCES 5.00% 1.83%
PFIZER 1.52% 7.69%
MBX BIOSCIENCES 0.47% 2.08%
Only in BMED
DANAHER 5.19%
MODERNA 5.19%
ABBVIE 4.61%
THERMO FISHER SCIENTIFIC INC 4.41%
JOHNSON & JOHNSON 4.17%
IQVIA HOLDINGS 3.75%
WATERS CORP 3.66%
BIOGEN 3.52%
Only in OZEM
Eli Lilly & Co 12.69%
Novo Nordisk A/S 11.09%
CSPC Pharmaceutical Group Ltd 6.52%
Viking Therapeutics Inc 5.47%
Kailera Therapeutics Inc 5.17%
Chugai Pharmaceutical Co Ltd 4.64%
Ascletis Pharma Inc 4.39%
Hanmi Pharm Co Ltd 4.33%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

6% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowBMEDOZEMBMEDOZEMBMEDOZEM
3 months+12.6%−4.9%+10.1 pts−7.5 pts+10.5 pts−7.1 pts
6 months+19.4%−3.5%+2.4 pts−20.5 pts−7.5 pts−30.4 pts
1 year+29.3%+14.0%+13.6 pts−1.7 pts+5.5 pts−9.8 pts
3 years+54.5%not published−30.5 ptsnot published−55.5 ptsnot published
Since launch
BMED Oct 2020 · OZEM May 2024
+35.9%+23.1%−109.5 pts−24.7 pts−135.6 pts−41.3 pts

BMED and OZEM over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

BMED
iShares Health Innovation Active ETF · Holds 60 stocks in healthcare innovation and GLP-1, 62% of its weight in S&P 500 companies
OZEM
Roundhill GLP-1 & Weight Loss ETF · Holds 26 stocks in healthcare innovation and GLP-1, 27% of its weight in S&P 500 companies
Issuer iShares Roundhill
Theme Healthcare innovation and GLP-1 Healthcare innovation and GLP-1
In the S&P 500 61.5% 26.6%
Active share vs the S&P 500 95.6% 97.8%
In the Nasdaq-100 13.2% 6.2%
Holdings 60 26
Top ten, share of the fund 42.9% 66.4%
Expense ratio 0.55% 0.59%
Fee for the differing part 0.58% 0.60%
Total return, 1 year +29.3% +14.0%
vs the S&P 500 +13.6 pts −1.7 pts
vs the Nasdaq-100 +5.5 pts −9.8 pts
Below its high −1.0% −16.8%
Net assets $14m $58m

BMED and OZEM on the same fields, as of Sep 30, 2026. Source: ETFIQ.

BMED in plain words

By weight, 62% of BMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 96%. The top ten holdings are 43% of the fund across 60 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +29.3% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 13.6 pts.

OZEM in plain words

By weight, 27% of OZEM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 66% of the fund across 26 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +14.0% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 1.7 pts. It sits 16.8% below its all-time high of Jan 26, 2026.

Questions people ask

Do BMED and OZEM hold the same stocks?
By their latest filings, 6% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BMED or OZEM?
BMED has 62% of its weight in S&P 500 names and OZEM has 27%, so OZEM differs more from the index.
Which is cheaper, BMED or OZEM?
BMED charges 0.55% a year and OZEM charges 0.59%, so BMED is cheaper. Fees come from each fund's prospectus.
Cite this page

ETFIQ, BMED against OZEM, data as of Sep 30, 2026. https://etfiq.com/compare/themes/bmed-vs-ozem

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.