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BBC vs XBI: which is really different?

BBC and XBI hold 32% of their weight in the same names, and BBC returned +51.4% over the year. Virtus Biotech Clinical Trials ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.

XBI costs 0.30 points a year less; their one-year returns differ by 6.4 points; XBI is far larger, $9.9bn against $46m.

BBCXBI
Expense ratio0.65%0.35%
Net assets, BBC as of Jul 31, 2026 and XBI as of Oct 8, 2026$46m$9.9bn
Total return, 1 year+51.4%+45.0%
What it tracksBiotechBiotech
Holdings in common32%
S&P 500, total return, 1 year+17.3%
Against the S&P 500, 1 yearahead by 34.1 ptsahead by 27.7 pts
Below its all-time high26.6%, high on Feb 8, 202111.1%, high on Feb 8, 2021

Holdings in common uses holdings dated Jul 31, 2026 and Oct 8, 2026.

0.0%
BBC in the S&P 500
12.7%
XBI in the S&P 500
+51.4%
BBC total return, 1 year
+45.0%
XBI total return, 1 year
BBC · 1 year to Oct 9, 2026100% of its weight is outside the S&P 500
100% of its weight is outside the S&P 5000% of BBC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Jul 31, 2026.0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 12% of the fund · 131 holdings as filed for Jul 31, 2026 · Nasdaq-100: 0% in100% of its weight is outside the S&P 5000% of BBC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Jul 31, 2026.0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · Nasdaq-100: 0% in

0% of BBC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Jul 31, 2026.

XBI · 1 year to Oct 9, 202687% of its weight is outside the S&P 500
87% of its weight is outside the S&P 50013% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.13%87%inof its weight outside the S&P 500active share 98% · top ten 17% of the fund · 165 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 9% in87% of its weight is outside the S&P 50013% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.13%87%inof its weight outside the S&P 500active share 98% · Nasdaq-100: 9% in

13% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · BBC scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, BBC and XBI hold 32% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jul 31, 2026 and Oct 8, 2026.

half

32% in common

Positions both hold, largest shared weight first
Holding BBC XBI
ORUKA THERAPEUTICS INC 0.93% 1.28%
DIANTHUS THERAPEUTICS INC 0.87% 1.17%
ERASCA INC 0.86% 1.33%
RELAY THERAPEUTICS INC 0.85% 0.87%
KODIAK SCIENCES INC 0.82% 1.24%
REVOLUTION MEDICINES INC 0.82% 1.37%
SPYRE THERAPEUTICS INC 0.81% 1.39%
KYMERA THERAPEUTICS INC 0.80% 1.20%
CG ONCOLOGY INC 0.80% 1.00%
COGENT BIOSCIENCES INC 0.79% 1.20%
PRAXIS PRECISION MEDICINES INC 0.77% 1.16%
VAXCYTE INC 0.76% 1.33%
Only in BBC
MBX BIOSCIENCES INC 1.24%
ATAIBECKLEY INC 1.23%
DEFINIUM THERAPEUTICS INC 1.18%
APOGEE THERAPEUTICS INC 1.02%
LB PHARMACEUTICALS INC 0.94%
AMYLYX PHARMACEUTICALS INC 0.93%
GH RESEARCH PLC 0.89%
SIONNA THERAPEUTICS INC 0.88%
Only in XBI
MODERNA INC 2.20%
TWIST BIOSCIENCE CORP 1.84%
NATERA INC 1.79%
ABBVIE INC 1.65%
UNITED THERAPEUTICS CORP 1.59%
AMGEN INC 1.58%
BIOGEN INC 1.57%
HALOZYME THERAPEUTICS INC 1.55%

32% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowBBCXBIBBCXBIBBCXBI
3 months−17.0%−3.3%−20.3 pts−6.7 pts−20.6 pts−7.0 pts
6 months+1.7%+18.9%−13.4 pts+3.8 pts−21.5 pts−4.3 pts
1 year+51.4%+45.0%+34.1 pts+27.7 pts+27.8 pts+21.4 pts
3 years+132.7%+114.6%+46.9 pts+28.8 pts+25.4 pts+7.3 pts
Since launch
BBC Dec 2014 · XBI Feb 2006
+74.9%+890.7%−296.4 pts+92.2 pts−633.5 pts−1,164.7 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

BBC
Virtus Biotech Clinical Trials ETF · Holds 131 stocks in biotech, 0% of its weight in S&P 500 companies
XBI
State Street(R) SPDR(R) S&P(R) Biotech ETF · Holds 165 stocks in biotech, 13% of its weight in S&P 500 companies
Issuer Virtus State Street
Theme Biotech Biotech
In the S&P 500 0.0% 12.7%
Active share vs the S&P 500 100.0% 98.4%
In the Nasdaq-100 0.0% 8.5%
Holdings 131 165
Top ten, share of the fund 11.8% 16.9%
Expense ratio 0.65% 0.35%
Fee for the differing part 0.65% 0.36%
Total return, 1 year +51.4% +45.0%
vs the S&P 500 +34.1 pts +27.7 pts
vs the Nasdaq-100 +27.8 pts +21.4 pts
Below its high −26.6% −11.1%
Net assets, BBC as of Jul 31, 2026 and XBI as of Oct 8, 2026 $46m $9.9bn

As of Oct 9, 2026. Source: ETFIQ.

BBC in plain words

By weight, 0% of BBC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 12% of the fund across 131 positions, as filed for Jul 31, 2026. Over the year to Oct 9, 2026 the fund returned +51.4% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 34.1 pts. It sits 26.6% below its all-time high of Feb 8, 2021.

XBI in plain words

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 17% of the fund across 165 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +45.0% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 27.7 pts. It sits 11.1% below its all-time high of Feb 8, 2021.

Questions people ask

Do BBC and XBI hold the same stocks?
By their latest filings, 32% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBC or XBI?
BBC has 0% of its weight in S&P 500 names and XBI has 13%, so BBC differs more from the index.
Which is cheaper, BBC or XBI?
BBC charges 0.65% a year and XBI charges 0.35%, so XBI is cheaper. Fees come from each fund's prospectus.
Other comparisons
BBC vs IBBBBC vs FBTBBC vs PBPHBBC vs IBBQXBI vs BBPXBI vs BBHXBI vs FBTXBI vs IBBQ
BBC on its own →XBI on its own →How every figure is computed →Standards and sources →
Where these figures came from
BBC filings on SEC EDGAR ↗BBC prospectus with the expense ratio (SEC) ↗Virtus website ↗XBI filings on SEC EDGAR ↗XBI prospectus with the expense ratio (SEC) ↗State Street website ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, BBC against XBI, data as of Oct 9, 2026. https://etfiq.com/compare/themes/bbc-vs-xbi

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.