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Data as of .

BBC vs PBPH: which is really different?

BBC and PBPH hold 0% of their weight in the same names.

Virtus Biotech Clinical Trials ETF and Portfolio Building Block World Pharma and Biotech Index ETF.

0.0%BBC in the S&P 500
56.8%PBPH in the S&P 500
+95.6%BBC total return, 1 year
+13.3%PBPH total return, 1 year

ETFIQ Off-Index Score: BBC scores higher

How much of it is not the index it is sold as an alternative to?

BBC 91.8PBPH 32.10.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

BBC100% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund · 124 holdings filed Apr 30, 2026 · Nasdaq-100: 0% in0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund
PBPH43% of its weight is outside the S&P 500 · 6 months to Sep 18, 2026
57%43%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 95% · top ten 63% of the fund · 51 holdings filed Jan 31, 2026 · Nasdaq-100: 15% in57%43%in the S&P 500outsideactive share 95% · top ten 63% of the fund

0% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, BBC and PBPH hold 0% of their money in the same securities at the same weight.

Positions BBC and PBPH both hold, largest shared weight first
HoldingBBCPBPH
REVOLUTION MEDICINES INC1.35%0.37%
Only in each
Only in BBCOnly in PBPH
ERASCA INC 2.19%ELI LILLY & CO 14.74%
ENLIVEN THERAPEUTICS INC 1.81%JOHNSON & JOHNSON 9.10%
TANGO THERAPEUTICS INC 1.71%ABBVIE INC 6.53%
ORUKA THERAPEUTICS INC 1.68%ROCHE HOLDING AG-GENUSSCHEIN 5.28%
SPYRE THERAPEUTICS INC 1.64%NOVARTIS AG-REG 4.99%
ALUMIS INC 1.59%MERCK & CO. INC. 4.71%
DIANTHUS THERAPEUTICS INC 1.54%ASTRAZENECA PLC 4.60%
KODIAK SCIENCES INC 1.35%NOVO NORDISK A/S-B 4.37%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Jan 31, 2026.

Performance, window by window

BBC and PBPH over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
BBCPBPHBBCPBPHBBCPBPH
3 months+6.9%+12.4%+4.7 pts+10.1 pts+9.4 pts+14.8 pts
6 months+22.7%+15.6%+4.7 pts−2.5 pts−1.5 pts−8.7 pts
1 year+95.6%not published+79.0 ptsnot published+73.8 ptsnot published
3 years+143.8%not published+65.3 ptsnot published+45.6 ptsnot published
Since launch+92.6%+13.3%−268.5 pts−0.8 pts−583.0 pts−5.7 pts
Open the live comparison on ETFIQ
BBC and PBPH on the same fields, as of Sep 18, 2026. Source: ETFIQ.
BBC
Virtus Biotech Clinical Trials ETF
Holds 124 stocks in biotech, 0% of its weight in S&P 500 companies
PBPH
Portfolio Building Block World Pharma and Biotech Index ETF
Holds 51 stocks in biotech, 57% of its weight in S&P 500 companies
IssuerVirtusPortfolio Building Block
ThemeBiotechBiotech
In the S&P 5000.0%56.8%
Active share vs the S&P 500100.0%95.0%
In the Nasdaq-1000.0%14.7%
Holdings12451
Top ten, share of the fund16.2%62.7%
Expense ratio0.65%0.13%
Fee for the differing part0.65%0.14%
Total return, 1 year+95.6%+13.3% (since launch on Nov 25, 2025)
vs the S&P 500+79.0 pts−0.8 pts
vs the Nasdaq-100+73.8 pts−5.7 pts
Below its high−19.1%−4.8%
Net assets$37m$36m

BBC in plain words

By weight, 0% of BBC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 16% of the fund across 124 positions, as filed for Apr 30, 2026. Over the year to Sep 18, 2026 the fund returned +95.6% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 79.0 pts. It sits 19.1% below its all-time high of Feb 8, 2021.

PBPH in plain words

By weight, 57% of PBPH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 63% of the fund across 51 positions, as filed for Jan 31, 2026. Since it launched on Nov 25, 2025 the fund returned +13.3% with distributions reinvested against +14.1% for the S&P 500, so a holder was behind by 0.8 pts.

Questions people ask

Do BBC and PBPH hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBC or PBPH?
BBC has 0% of its weight in S&P 500 names and PBPH has 57%, so BBC differs more from the index.
Which is cheaper, BBC or PBPH?
BBC charges 0.65% a year and PBPH charges 0.13%, so PBPH is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

BBC against PBPH, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, BBC against PBPH, data as of Sep 18, 2026. https://etfiq.com/compare/themes/bbc-vs-pbph Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources