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Data as of .

FBT vs PBPH: which is really different?

FBT and PBPH hold 17% of their weight in the same names.

First Trust NYSE Arca Biotechnology Index Fund and Portfolio Building Block World Pharma and Biotech Index ETF.

23.6%FBT in the S&P 500
56.8%PBPH in the S&P 500
+48.9%FBT total return, 1 year
+13.3%PBPH total return, 1 year

ETFIQ Off-Index Score: FBT scores higher

How much of it is not the index it is sold as an alternative to?

FBT 64.1PBPH 32.10.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

FBT76% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
24%76%in the S&P 500of its weight outside the S&P 500active share 99% · top ten 39% of the fund · 31 holdings filed Sep 18, 2026 · Nasdaq-100: 16% in24%76%inoutside the S&P 500active share 99% · top ten 39% of the fund
PBPH43% of its weight is outside the S&P 500 · 6 months to Sep 18, 2026
57%43%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 95% · top ten 63% of the fund · 51 holdings filed Jan 31, 2026 · Nasdaq-100: 15% in57%43%in the S&P 500outsideactive share 95% · top ten 63% of the fund

17% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, FBT and PBPH hold 17% of their money in the same securities at the same weight.

Positions FBT and PBPH both hold, largest shared weight first
HoldingFBTPBPH
Gilead Sciences, Inc.3.58%4.10%
Amgen Inc.3.29%4.33%
Natera, Inc.4.24%0.71%
Biogen Inc.3.35%0.62%
BioMarin Pharmaceutical Inc.3.35%0.24%
Exelixis, Inc.3.20%0.24%
Only in each
Only in FBTOnly in PBPH
Halozyme Therapeutics, Inc. 4.57%ELI LILLY & CO 14.74%
NeoGenomics, Inc. 4.37%JOHNSON & JOHNSON 9.10%
Illumina, Inc. 3.90%ABBVIE INC 6.53%
Repligen Corporation 3.80%ROCHE HOLDING AG-GENUSSCHEIN 5.28%
Corcept Therapeutics Inc. 3.72%NOVARTIS AG-REG 4.99%
Genmab A/S (ADR) 3.71%MERCK & CO. INC. 4.71%
Regeneron Pharmaceuticals, Inc. 3.66%ASTRAZENECA PLC 4.60%
BeOne Medicines Ltd. (ADR) 3.64%NOVO NORDISK A/S-B 4.37%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jan 31, 2026 and Sep 18, 2026.

Performance, window by window

FBT and PBPH over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
FBTPBPHFBTPBPHFBTPBPH
3 months+17.2%+12.4%+14.9 pts+10.1 pts+19.6 pts+14.8 pts
6 months+40.6%+15.6%+22.6 pts−2.5 pts+16.4 pts−8.7 pts
1 year+48.9%not published+32.3 ptsnot published+27.1 ptsnot published
3 years+80.7%not published+2.3 ptsnot published−17.5 ptsnot published
Since launch+848.2%+13.3%+44.6 pts−0.8 pts−842.1 pts−5.7 pts
Open the live comparison on ETFIQ
FBT and PBPH on the same fields, as of Sep 18, 2026. Source: ETFIQ.
FBT
First Trust NYSE Arca Biotechnology Index Fund
Holds 31 stocks in biotech, 24% of its weight in S&P 500 companies
PBPH
Portfolio Building Block World Pharma and Biotech Index ETF
Holds 51 stocks in biotech, 57% of its weight in S&P 500 companies
IssuerFirst TrustPortfolio Building Block
ThemeBiotechBiotech
In the S&P 50023.6%56.8%
Active share vs the S&P 50099.1%95.0%
In the Nasdaq-10016.2%14.7%
Holdings3151
Top ten, share of the fund39.2%62.7%
Expense ratio0.55%0.13%
Fee for the differing part0.55%0.14%
Total return, 1 year+48.9%+13.3% (since launch on Nov 25, 2025)
vs the S&P 500+32.3 pts−0.8 pts
vs the Nasdaq-100+27.1 pts−5.7 pts
Below its high−2.1%−4.8%
Net assets$2.9bn$36m

FBT in plain words

By weight, 24% of FBT's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 39% of the fund across 31 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +48.9% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 32.3 pts.

PBPH in plain words

By weight, 57% of PBPH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 63% of the fund across 51 positions, as filed for Jan 31, 2026. Since it launched on Nov 25, 2025 the fund returned +13.3% with distributions reinvested against +14.1% for the S&P 500, so a holder was behind by 0.8 pts.

Questions people ask

Do FBT and PBPH hold the same stocks?
By their latest filings, 17% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FBT or PBPH?
FBT has 24% of its weight in S&P 500 names and PBPH has 57%, so FBT differs more from the index.
Which is cheaper, FBT or PBPH?
FBT charges 0.55% a year and PBPH charges 0.13%, so PBPH is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

FBT against PBPH, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, FBT against PBPH, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fbt-vs-pbph Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources