Do PBPH and XBI hold the same stocks?

By their latest filings, 14% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, PBPH or XBI?

PBPH has 59% of its weight in S&P 500 names and XBI has 13%, so XBI differs more from the index.

Which is cheaper, PBPH or XBI?

PBPH charges 0.13% a year and XBI charges 0.35%, so PBPH is cheaper. Fees come from each fund's prospectus.

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PBPH vs XBI: which is really different?

PBPH and XBI hold 14% of their weight in the same names. Portfolio Building Block World Pharma and Biotech Index ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.

PBPH costs 0.22 points a year less; XBI is 10.4 times larger.

	PBPH	XBI
Expense ratio	0.13%	0.35%
Net assets, PBPH as of Jul 31, 2026 and XBI as of Oct 8, 2026	$952m	$9.9bn
Total return, 1 year	not published	+45.0%
What it tracks	Biotech	Biotech
Holdings in common	14%
S&P 500, total return, since Nov 25, 2025	+16.6%
S&P 500, total return, 1 year		+17.3%
Against the S&P 500, since Nov 25, 2025	behind by 3.4 pts
Against the S&P 500, 1 year		ahead by 27.7 pts
Below its all-time high		11.1%, high on Feb 8, 2021

Holdings in common uses holdings dated Jul 31, 2026 and Oct 8, 2026.

59.2%

PBPH in the S&P 500

12.7%

XBI in the S&P 500

+13.2%

PBPH total return, since launch

+45.0%

XBI total return, 1 year

PBPH · 6 months to Oct 9, 202641% of its weight is outside the S&P 500

59% of PBPH's weight is in S&P 500 companies and 41% is outside the index. Holdings as of Jul 31, 2026.

XBI · 1 year to Oct 9, 202687% of its weight is outside the S&P 500

13% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · XBI scores higherHow much of it is not the index it is sold as an alternative to?

PBPH 32.1

XBI 55.2

0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, PBPH and XBI hold 14% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jul 31, 2026 and Oct 8, 2026.

50%

half

14% in common

Positions both hold, largest shared weight first

Holding PBPH XBI

ABBVIE INC 6.94% 1.65%

AMGEN INC 4.63% 1.58%

GILEAD SCIENCES INC 3.77% 1.53%

VERTEX PHARMACEUTICALS INC 2.82% 1.47%

REGENERON PHARMACEUTICALS INC 1.79% 1.39%

NATERA INC 0.85% 1.79%

REVOLUTION MEDICINES INC 0.77% 1.37%

BIOGEN INC 0.70% 1.57%

ALNYLAM PHARMACEUTICALS INC 0.63% 1.32%

INCYTE CORP 0.56% 1.36%

UNITED THERAPEUTICS CORP 0.51% 1.59%

INSMED INC 0.48% 1.18%

Only in PBPH

ELI LILLY & COMPANY 15.20%

JOHNSON & JOHNSON 9.66%

MERCK & COMPANY INC 5.04%

ROCHE HOLDING AG 4.74%

NOVARTIS AG 4.47%

ASTRAZENECA PLC 3.90%

NOVO NORDISK A/S 3.51%

PFIZER INC 3.33%

Only in XBI

TWIST BIOSCIENCE CORP 1.84%

HALOZYME THERAPEUTICS INC 1.55%

IOVANCE BIOTHERAPEUTICS INC 1.54%

TG THERAPEUTICS INC 1.48%

PROTAGONIST THERAPEUTICS INC 1.46%

KRYSTAL BIOTECH INC 1.43%

CRISPR THERAPEUTICS AG 1.41%

PTC THERAPEUTICS INC 1.40%

14% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	PBPH	XBI	PBPH	XBI	PBPH	XBI
3 months	+4.7%	−3.3%	+1.3 pts	−6.7 pts	+1.0 pts	−7.0 pts
6 months	+11.0%	+18.9%	−4.1 pts	+3.8 pts	−12.2 pts	−4.3 pts
1 year	not published	+45.0%	not published	+27.7 pts	not published	+21.4 pts
3 years	not published	+114.6%	not published	+28.8 pts	not published	+7.3 pts
Since launch PBPH Nov 2025 · XBI Feb 2006	+13.2%	+890.7%	−3.4 pts	+92.2 pts	−10.8 pts	−1,164.7 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

PBPH

Portfolio Building Block World Pharma and Biotech Index ETF · Holds 53 stocks in biotech, 59% of its weight in S&P 500 companies

XBI

State Street(R) SPDR(R) S&P(R) Biotech ETF · Holds 165 stocks in biotech, 13% of its weight in S&P 500 companies

Issuer Portfolio Building Block State Street

Theme Biotech Biotech

In the S&P 500 59.2% 12.7%

Active share vs the S&P 500 95.0% 98.4%

In the Nasdaq-100 14.1% 8.5%

Holdings 53 165

Top ten, share of the fund 61.9% 16.9%

Expense ratio 0.13% 0.35%

Fee for the differing part 0.14% 0.36%

Total return, 1 year +13.2% (since it first traded on Nov 25, 2025) +45.0%

vs the S&P 500 −3.4 pts +27.7 pts

vs the Nasdaq-100 −10.8 pts +21.4 pts

Below its high −4.8% −11.1%

Net assets, PBPH as of Jul 31, 2026 and XBI as of Oct 8, 2026 $952m $9.9bn

As of Oct 9, 2026. Source: ETFIQ.

PBPH in plain words

By weight, 59% of PBPH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 62% of the fund across 53 positions, as filed for Jul 31, 2026. Since it first traded on Nov 25, 2025 the fund returned +13.2% with distributions reinvested against +16.6% for the S&P 500, so a holder was behind by 3.4 pts.

XBI in plain words

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 17% of the fund across 165 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +45.0% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 27.7 pts. It sits 11.1% below its all-time high of Feb 8, 2021.

Questions people ask

Do PBPH and XBI hold the same stocks?: By their latest filings, 14% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, PBPH or XBI?: PBPH has 59% of its weight in S&P 500 names and XBI has 13%, so XBI differs more from the index.
Which is cheaper, PBPH or XBI?: PBPH charges 0.13% a year and XBI charges 0.35%, so PBPH is cheaper. Fees come from each fund's prospectus.

Other comparisons

PBPH vs IBB PBPH vs FBT PBPH vs BBC PBPH vs BBH XBI vs BBH XBI vs BBC XBI vs FBT XBI vs BBP

PBPH on its own →XBI on its own →How every figure is computed →Standards and sources →

Where these figures came from

PBPH filings on SEC EDGAR ↗PBPH prospectus with the expense ratio (SEC) ↗Portfolio Building Block page for PBPH ↗XBI filings on SEC EDGAR ↗XBI prospectus with the expense ratio (SEC) ↗State Street website ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, PBPH against XBI, data as of Oct 9, 2026. https://etfiq.com/compare/themes/pbph-vs-xbi

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.