BBP vs XBI: which is really different?

BBP and XBI hold 46% of their weight in the same names. Virtus Biotech ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.

BBP costs 0.01 points a year less; their one-year returns differ by 0.2 points; XBI is far larger, $9.9bn against $99m.

BBPXBI
Expense ratio0.34%0.35%
Net assets, BBP as of Jul 31, 2026 and XBI as of Oct 8, 2026$99m$9.9bn
Total return, 1 year+45.2%+45.0%
What it tracksBiotechBiotech
Holdings in common46%
S&P 500, total return, 1 year+17.3%
Against the S&P 500, 1 yearahead by 27.9 ptsahead by 27.7 pts
Below its all-time high11.1%, high on Feb 8, 2021

Holdings in common uses holdings dated Jul 31, 2026 and Oct 8, 2026.

10.6%
BBP in the S&P 500
12.7%
XBI in the S&P 500
+45.2%
BBP total return, 1 year
+45.0%
XBI total return, 1 year
BBP · 1 year to Oct 9, 202689% of its weight is outside the S&P 500
89% of its weight is outside the S&P 50011% of BBP's weight is in S&P 500 companies and 89% is outside the index. Holdings as of Jul 31, 2026.11%89%inof its weight outside the S&P 500active share 99% · top ten 20% of the fund · 67 holdings as filed for Jul 31, 2026 · Nasdaq-100: 9% in89% of its weight is outside the S&P 50011% of BBP's weight is in S&P 500 companies and 89% is outside the index. Holdings as of Jul 31, 2026.11%89%inof its weight outside the S&P 500active share 99% · Nasdaq-100: 9% in

11% of BBP's weight is in S&P 500 companies and 89% is outside the index. Holdings as of Jul 31, 2026.

XBI · 1 year to Oct 9, 202687% of its weight is outside the S&P 500
87% of its weight is outside the S&P 50013% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.13%87%inof its weight outside the S&P 500active share 98% · top ten 17% of the fund · 165 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 9% in87% of its weight is outside the S&P 50013% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.13%87%inof its weight outside the S&P 500active share 98% · Nasdaq-100: 9% in

13% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · BBP scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, BBP and XBI hold 46% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jul 31, 2026 and Oct 8, 2026.

half

46% in common

Positions both hold, largest shared weight first
Holding BBP XBI
HALOZYME THERAPEUTICS INC 1.64% 1.55%
MODERNA INC 1.51% 2.20%
AMGEN INC 1.49% 1.58%
VERTEX PHARMACEUTICALS INC 1.48% 1.47%
PROTAGONIST THERAPEUTICS INC 1.71% 1.46%
TG THERAPEUTICS INC 1.45% 1.48%
GILEAD SCIENCES INC 1.43% 1.53%
KRYSTAL BIOTECH INC 1.48% 1.43%
BIOGEN INC 1.40% 1.57%
REGENERON PHARMACEUTICALS 1.72% 1.39%
NEUROCRINE BIOSCIENCES INC 1.44% 1.38%
EXELIXIS INC 1.38% 1.53%
Only in BBP
CRINETICS PHARMACEUTICALS INC 3.34%
KINIKSA PHARMACEUTICALS INTERNATIONAL PLC 1.97%
OMEROS CORP 1.87%
NUVATION BIO INC 1.77%
BEONE MEDICINES LTD 1.65%
XERIS BIOPHARMA HOLDINGS INC 1.64%
LIQUIDIA CORP 1.63%
IMMUNOCORE HOLDINGS PLC 1.61%
Only in XBI
TWIST BIOSCIENCE CORP 1.84%
NATERA INC 1.79%
ABBVIE INC 1.65%
SPYRE THERAPEUTICS INC 1.39%
REVOLUTION MEDICINES INC 1.37%
ALKERMES PLC 1.34%
GRAIL INC 1.33%
ERASCA INC 1.33%

46% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowBBPXBIBBPXBIBBPXBI
3 months+4.5%−3.3%+1.1 pts−6.7 pts+0.8 pts−7.0 pts
6 months+24.3%+18.9%+9.2 pts+3.8 pts+1.1 pts−4.3 pts
1 year+45.2%+45.0%+27.9 pts+27.7 pts+21.6 pts+21.4 pts
3 years+110.3%+114.6%+24.5 pts+28.8 pts+3.0 pts+7.3 pts
Since launch
BBP Dec 2014 · XBI Feb 2006
+308.1%+890.7%−63.1 pts+92.2 pts−400.3 pts−1,164.7 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

BBP
Virtus Biotech ETF · Holds 67 stocks in biotech, 11% of its weight in S&P 500 companies
XBI
State Street(R) SPDR(R) S&P(R) Biotech ETF · Holds 165 stocks in biotech, 13% of its weight in S&P 500 companies
Theme Biotech Biotech
In the S&P 500 10.6% 12.7%
Active share vs the S&P 500 99.0% 98.4%
In the Nasdaq-100 8.5% 8.5%
Holdings 67 165
Top ten, share of the fund 19.6% 16.9%
Expense ratio 0.34% 0.35%
Fee for the differing part 0.34% 0.36%
Total return, 1 year +45.2% +45.0%
vs the S&P 500 +27.9 pts +27.7 pts
vs the Nasdaq-100 +21.6 pts +21.4 pts
Below its high −4.7% −11.1%
Net assets, BBP as of Jul 31, 2026 and XBI as of Oct 8, 2026 $99m $9.9bn

As of Oct 9, 2026. Source: ETFIQ.

BBP in plain words

By weight, 11% of BBP's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 20% of the fund across 67 positions, as filed for Jul 31, 2026. Over the year to Oct 9, 2026 the fund returned +45.2% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 27.9 pts.

XBI in plain words

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 17% of the fund across 165 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +45.0% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 27.7 pts. It sits 11.1% below its all-time high of Feb 8, 2021.

Questions people ask

Do BBP and XBI hold the same stocks?
By their latest filings, 46% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBP or XBI?
BBP has 11% of its weight in S&P 500 names and XBI has 13%, so BBP differs more from the index.
Which is cheaper, BBP or XBI?
BBP charges 0.34% a year and XBI charges 0.35%, so BBP is cheaper. Fees come from each fund's prospectus.
Other comparisons
Where these figures came from

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, BBP against XBI, data as of Oct 9, 2026. https://etfiq.com/compare/themes/bbp-vs-xbi

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.