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Data as of .

BBC vs IBBQ: which is really different?

BBC and IBBQ hold 17% of their weight in the same names, and BBC returned more over the year.

Virtus Biotech Clinical Trials ETF and Invesco Nasdaq Biotechnology ETF.

0.0%BBC in the S&P 500
38.6%IBBQ in the S&P 500
+95.6%BBC total return, 1 year
+44.6%IBBQ total return, 1 year

ETFIQ Off-Index Score: BBC scores higher

How much of it is not the index it is sold as an alternative to?

BBC 91.8IBBQ 61.70.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

BBC100% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund · 124 holdings filed Apr 30, 2026 · Nasdaq-100: 0% in0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund
IBBQ61% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
39%61%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 45% of the fund · 256 holdings filed Sep 19, 2026 · Nasdaq-100: 33% in39%61%in the S&P 500outside the S&P 500active share 99% · top ten 45% of the fund

17% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, BBC and IBBQ hold 17% of their money in the same securities at the same weight.

Positions BBC and IBBQ both hold, largest shared weight first
HoldingBBCIBBQ
REVOLUTION MEDICINES INC1.35%2.72%
SUMMIT THERAPEUTICS INC0.90%0.93%
KYMERA THERAPEUTICS INC0.67%0.65%
CYTOKINETICS INC0.75%0.63%
PROTAGONIST THERAPEUTICS INC0.77%0.62%
VAXCYTE INC0.95%0.56%
PRAXIS PRECISION MEDICINES INC0.88%0.56%
SPYRE THERAPEUTICS INC1.64%0.53%
IMMUNOVANT INC0.76%0.51%
CG ONCOLOGY INC1.21%0.44%
ORUKA THERAPEUTICS INC1.68%0.38%
SCHOLAR ROCK HOLDING CORP0.74%0.37%
Only in each
Only in BBCOnly in IBBQ
DIANTHUS THERAPEUTICS INC 1.54%Amgen Inc 8.05%
REZOLUTE INC 1.31%Vertex Pharmaceuticals Inc 7.98%
JADE BIOSCIENCES INC 1.21%Gilead Sciences Inc 7.89%
NEKTAR THERAPEUTICS 1.15%Regeneron Pharmaceuticals Inc 5.42%
CENTESSA PHARMACEUTICALS PLC 1.10%Moderna Inc 4.10%
PALVELLA THERAPEUTICS INC 0.96%Illumina Inc 2.43%
CAPRICOR THERAPEUTICS INC 0.95%Alnylam Pharmaceuticals Inc 2.14%
CELLDEX THERAPEUTICS INC 0.88%Biogen Inc 2.13%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Sep 19, 2026.

Performance, window by window

BBC and IBBQ over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
BBCIBBQBBCIBBQBBCIBBQ
3 months+6.9%+15.8%+4.7 pts+13.6 pts+9.4 pts+18.3 pts
6 months+22.7%+24.9%+4.7 pts+6.9 pts−1.5 pts+0.7 pts
1 year+95.6%+44.6%+79.0 pts+28.0 pts+73.8 pts+22.8 pts
3 years+143.8%+76.7%+65.3 pts−1.7 pts+45.6 pts−21.5 pts
Since launch+92.6%+42.0%−268.5 pts−51.2 pts−583.0 pts−76.1 pts
Open the live comparison on ETFIQ
BBC and IBBQ on the same fields, as of Sep 18, 2026. Source: ETFIQ.
BBC
Virtus Biotech Clinical Trials ETF
Holds 124 stocks in biotech, 0% of its weight in S&P 500 companies
IBBQ
Invesco Nasdaq Biotechnology ETF
Holds 256 stocks in biotech, 39% of its weight in S&P 500 companies
IssuerVirtusInvesco
ThemeBiotechBiotech
In the S&P 5000.0%38.6%
Active share vs the S&P 500100.0%99.0%
In the Nasdaq-1000.0%33.2%
Holdings124256
Top ten, share of the fund16.2%44.8%
Expense ratio0.65%0.19%
Fee for the differing part0.65%0.19%
Total return, 1 year+95.6%+44.6%
vs the S&P 500+79.0 pts+28.0 pts
vs the Nasdaq-100+73.8 pts+22.8 pts
Below its high−19.1%−5.8%
Net assets$37m$96m

BBC in plain words

By weight, 0% of BBC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 16% of the fund across 124 positions, as filed for Apr 30, 2026. Over the year to Sep 18, 2026 the fund returned +95.6% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 79.0 pts. It sits 19.1% below its all-time high of Feb 8, 2021.

IBBQ in plain words

By weight, 39% of IBBQ's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 45% of the fund across 256 positions, as published by its issuer for Sep 19, 2026. Over the year to Sep 18, 2026 the fund returned +44.6% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 28.0 pts. It sits 5.8% below its all-time high of Aug 19, 2026.

Questions people ask

Do BBC and IBBQ hold the same stocks?
By their latest filings, 17% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBC or IBBQ?
BBC has 0% of its weight in S&P 500 names and IBBQ has 39%, so BBC differs more from the index.
Which is cheaper, BBC or IBBQ?
BBC charges 0.65% a year and IBBQ charges 0.19%, so IBBQ is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

BBC against IBBQ, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, BBC against IBBQ, data as of Sep 18, 2026. https://etfiq.com/compare/themes/bbc-vs-ibbq Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources