BBC vs IBB: which is really different?

BBC and IBB hold 12% of their weight in the same names, and BBC returned +51.4% over the year. Virtus Biotech Clinical Trials ETF and iShares Biotechnology ETF.

IBB costs 0.21 points a year less; their one-year returns differ by 15.3 points; IBB is far larger, $10.8bn against $46m.

BBCIBB
Expense ratio0.65%0.44%
Net assets, BBC as of Jul 31, 2026 and IBB as of Oct 9, 2026$46m$10.8bn
Total return, 1 year+51.4%+36.1%
What it tracksBiotechBiotech
Holdings in common12%
S&P 500, total return, 1 year+17.3%
Against the S&P 500, 1 yearahead by 34.1 ptsahead by 18.8 pts
Below its all-time high26.6%, high on Feb 8, 2021

Holdings in common uses holdings dated Jul 31, 2026 and Oct 8, 2026.

0.0%
BBC in the S&P 500
39.5%
IBB in the S&P 500
+51.4%
BBC total return, 1 year
+36.1%
IBB total return, 1 year
BBC · 1 year to Oct 9, 2026100% of its weight is outside the S&P 500
100% of its weight is outside the S&P 5000% of BBC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Jul 31, 2026.0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 12% of the fund · 131 holdings as filed for Jul 31, 2026 · Nasdaq-100: 0% in100% of its weight is outside the S&P 5000% of BBC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Jul 31, 2026.0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · Nasdaq-100: 0% in

0% of BBC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Jul 31, 2026.

IBB · 1 year to Oct 9, 202661% of its weight is outside the S&P 500
61% of its weight is outside the S&P 50040% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.40%61%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 50% of the fund · 245 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 33% in61% of its weight is outside the S&P 50040% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.40%61%in the S&P 500outside the S&P 500active share 99% · Nasdaq-100: 33% in

40% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · BBC scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, BBC and IBB hold 12% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jul 31, 2026 and Oct 8, 2026.

half

12% in common

Positions both hold, largest shared weight first
Holding BBC IBB
REVOLUTION MEDICINES INC 0.82% 2.67%
VAXCYTE INC 0.76% 0.70%
KYMERA THERAPEUTICS INC 0.80% 0.60%
PRAXIS PRECISION MEDICINES INC 0.77% 0.51%
SPYRE THERAPEUTICS INC 0.81% 0.47%
KODIAK SCIENCES INC 0.82% 0.40%
COGENT BIOSCIENCES INC 0.79% 0.34%
ORUKA THERAPEUTICS INC 0.93% 0.33%
DEFINIUM THERAPEUTICS INC 1.18% 0.32%
SCHOLAR ROCK HOLDING CORP 0.72% 0.31%
ERASCA INC 0.86% 0.28%
CG ONCOLOGY INC 0.80% 0.27%
Only in BBC
FIRST TRACKS BIOTHERAPEUTICS INC 1.67%
ATAIBECKLEY INC 1.23%
MONOPAR THERAPEUTICS INC 1.21%
APOGEE THERAPEUTICS INC 1.02%
VOR BIOPHARMA INC 0.99%
LB PHARMACEUTICALS INC 0.94%
DAMORA THERAPEUTICS INC 0.94%
DIANTHUS THERAPEUTICS INC 0.87%
Only in IBB
GILEAD SCIENCES 8.37%
AMGEN INC 7.89%
VERTEX PHARMACEUTICALS 7.69%
REGENERON PHARMACEUTICALS 5.40%
MODERNA 5.30%
NATERA 3.88%
ARGENX SE ADR 3.35%
ILLUMINA INC 2.94%

12% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowBBCIBBBBCIBBBBCIBB
3 months−17.0%+7.5%−20.3 pts+4.1 pts−20.6 pts+3.9 pts
6 months+1.7%+21.9%−13.4 pts+6.8 pts−21.5 pts−1.3 pts
1 year+51.4%+36.1%+34.1 pts+18.8 pts+27.8 pts+12.5 pts
3 years+132.7%+69.1%+46.9 pts−16.7 pts+25.4 pts−38.2 pts
Since launch
BBC Dec 2014 · IBB Feb 2001
+74.9%+525.3%−296.4 pts−299.7 pts−633.5 pts−936.3 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

BBC
Virtus Biotech Clinical Trials ETF · Holds 131 stocks in biotech, 0% of its weight in S&P 500 companies
IBB
iShares Biotechnology ETF · Holds 245 stocks in biotech, 40% of its weight in S&P 500 companies
Theme Biotech Biotech
In the S&P 500 0.0% 39.5%
Active share vs the S&P 500 100.0% 99.0%
In the Nasdaq-100 0.0% 33.1%
Holdings 131 245
Top ten, share of the fund 11.8% 49.9%
Expense ratio 0.65% 0.44%
Fee for the differing part 0.65% 0.44%
Total return, 1 year +51.4% +36.1%
vs the S&P 500 +34.1 pts +18.8 pts
vs the Nasdaq-100 +27.8 pts +12.5 pts
Below its high −26.6% −4.8%
Net assets, BBC as of Jul 31, 2026 and IBB as of Oct 9, 2026 $46m $10.8bn

As of Oct 9, 2026. Source: ETFIQ.

BBC in plain words

By weight, 0% of BBC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 12% of the fund across 131 positions, as filed for Jul 31, 2026. Over the year to Oct 9, 2026 the fund returned +51.4% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 34.1 pts. It sits 26.6% below its all-time high of Feb 8, 2021.

IBB in plain words

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +36.1% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 18.8 pts.

Questions people ask

Do BBC and IBB hold the same stocks?
By their latest filings, 12% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBC or IBB?
BBC has 0% of its weight in S&P 500 names and IBB has 40%, so BBC differs more from the index.
Which is cheaper, BBC or IBB?
BBC charges 0.65% a year and IBB charges 0.44%, so IBB is cheaper. Fees come from each fund's prospectus.
Other comparisons
Where these figures came from

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, BBC against IBB, data as of Oct 9, 2026. https://etfiq.com/compare/themes/bbc-vs-ibb

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.