Get the weekly note
ETFIQetfiq.com · independent ETF data

Data as of .

BBC vs FBT: which is really different?

BBC and FBT hold 0% of their weight in the same names, and BBC returned more over the year.

Virtus Biotech Clinical Trials ETF and First Trust NYSE Arca Biotechnology Index Fund.

0.0%BBC in the S&P 500
23.6%FBT in the S&P 500
+95.6%BBC total return, 1 year
+48.9%FBT total return, 1 year

ETFIQ Off-Index Score: BBC scores higher

How much of it is not the index it is sold as an alternative to?

BBC 91.8FBT 64.10.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

BBC100% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund · 124 holdings filed Apr 30, 2026 · Nasdaq-100: 0% in0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund
FBT76% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
24%76%in the S&P 500of its weight outside the S&P 500active share 99% · top ten 39% of the fund · 31 holdings filed Sep 18, 2026 · Nasdaq-100: 16% in24%76%inoutside the S&P 500active share 99% · top ten 39% of the fund

0% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, BBC and FBT hold 0% of their money in the same securities at the same weight.

Only in each
Only in BBCOnly in FBT
ERASCA INC 2.19%Halozyme Therapeutics, Inc. 4.57%
ENLIVEN THERAPEUTICS INC 1.81%NeoGenomics, Inc. 4.37%
TANGO THERAPEUTICS INC 1.71%Natera, Inc. 4.24%
ORUKA THERAPEUTICS INC 1.68%Illumina, Inc. 3.90%
SPYRE THERAPEUTICS INC 1.64%Repligen Corporation 3.80%
ALUMIS INC 1.59%Corcept Therapeutics Inc. 3.72%
DIANTHUS THERAPEUTICS INC 1.54%Genmab A/S (ADR) 3.71%
KODIAK SCIENCES INC 1.35%Regeneron Pharmaceuticals, Inc. 3.66%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Sep 18, 2026.

Performance, window by window

BBC and FBT over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
BBCFBTBBCFBTBBCFBT
3 months+6.9%+17.2%+4.7 pts+14.9 pts+9.4 pts+19.6 pts
6 months+22.7%+40.6%+4.7 pts+22.6 pts−1.5 pts+16.4 pts
1 year+95.6%+48.9%+79.0 pts+32.3 pts+73.8 pts+27.1 pts
3 years+143.8%+80.7%+65.3 pts+2.3 pts+45.6 pts−17.5 pts
Since launch+92.6%+848.2%−268.5 pts+44.6 pts−583.0 pts−842.1 pts
Open the live comparison on ETFIQ
BBC and FBT on the same fields, as of Sep 18, 2026. Source: ETFIQ.
BBC
Virtus Biotech Clinical Trials ETF
Holds 124 stocks in biotech, 0% of its weight in S&P 500 companies
FBT
First Trust NYSE Arca Biotechnology Index Fund
Holds 31 stocks in biotech, 24% of its weight in S&P 500 companies
IssuerVirtusFirst Trust
ThemeBiotechBiotech
In the S&P 5000.0%23.6%
Active share vs the S&P 500100.0%99.1%
In the Nasdaq-1000.0%16.2%
Holdings12431
Top ten, share of the fund16.2%39.2%
Expense ratio0.65%0.55%
Fee for the differing part0.65%0.55%
Total return, 1 year+95.6%+48.9%
vs the S&P 500+79.0 pts+32.3 pts
vs the Nasdaq-100+73.8 pts+27.1 pts
Below its high−19.1%−2.1%
Net assets$37m$2.9bn

BBC in plain words

By weight, 0% of BBC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 16% of the fund across 124 positions, as filed for Apr 30, 2026. Over the year to Sep 18, 2026 the fund returned +95.6% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 79.0 pts. It sits 19.1% below its all-time high of Feb 8, 2021.

FBT in plain words

By weight, 24% of FBT's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 39% of the fund across 31 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +48.9% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 32.3 pts.

Questions people ask

Do BBC and FBT hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBC or FBT?
BBC has 0% of its weight in S&P 500 names and FBT has 24%, so BBC differs more from the index.
Which is cheaper, BBC or FBT?
BBC charges 0.65% a year and FBT charges 0.55%, so FBT is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

BBC against FBT, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, BBC against FBT, data as of Sep 18, 2026. https://etfiq.com/compare/themes/bbc-vs-fbt Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources