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IBB vs IBBQ: which is really different?

IBB and IBBQ hold 86% of their weight in the same names, and IBBQ returned +37.2% over the year. iShares Biotechnology ETF and Invesco Nasdaq Biotechnology ETF.

IBBQ costs 0.25 points a year less; their one-year returns differ by 1.1 points; IBB is far larger, $10.8bn against $108m.

IBBIBBQ
Expense ratio0.44%0.19%
Net assets, IBB as of Oct 9, 2026 and IBBQ as of Oct 8, 2026$10.8bn$108m
Total return, 1 year+36.1%+37.2%
What it tracksBiotechBiotech
Holdings in common86%
S&P 500, total return, 1 year+17.3%
Against the S&P 500, 1 yearahead by 18.8 ptsahead by 20.0 pts
Below its all-time high5.3%, high on Aug 19, 2026

Holdings in common uses holdings dated Oct 8, 2026.

39.5%
IBB in the S&P 500
39.8%
IBBQ in the S&P 500
+36.1%
IBB total return, 1 year
+37.2%
IBBQ total return, 1 year
IBB · 1 year to Oct 9, 202661% of its weight is outside the S&P 500
61% of its weight is outside the S&P 50040% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.40%61%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 50% of the fund · 245 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 33% in61% of its weight is outside the S&P 50040% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.40%61%in the S&P 500outside the S&P 500active share 99% · Nasdaq-100: 33% in

40% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.

IBBQ · 1 year to Oct 9, 202660% of its weight is outside the S&P 500
60% of its weight is outside the S&P 50040% of IBBQ's weight is in S&P 500 companies and 60% is outside the index. Holdings as of Oct 8, 2026.40%60%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 46% of the fund · 255 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 33% in60% of its weight is outside the S&P 50040% of IBBQ's weight is in S&P 500 companies and 60% is outside the index. Holdings as of Oct 8, 2026.40%60%in the S&P 500outside the S&P 500active share 99% · Nasdaq-100: 33% in

40% of IBBQ's weight is in S&P 500 companies and 60% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · IBB and IBBQ score the sameHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, IBB and IBBQ hold 86% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Oct 8, 2026.

half

86% in common

Positions both hold, largest shared weight first
Holding IBB IBBQ
GILEAD SCIENCES 8.37% 8.42%
AMGEN INC 7.89% 7.94%
VERTEX PHARMACEUTICALS 7.69% 7.74%
MODERNA 5.30% 5.39%
REGENERON PHARMACEUTICALS 5.40% 5.12%
ILLUMINA INC 2.94% 2.74%
REVOLUTION MEDICINES 2.67% 2.76%
BIOGEN 2.36% 2.21%
ALNYLAM PHARMACEUTICALS 2.21% 2.06%
UNITED THERAPEUTICS 1.63% 1.57%
INCYTE CORP 1.67% 1.57%
ARGENX SE ADR 3.35% 1.52%
Only in IBB
NATERA 3.88%
CHARLES RIVER LABORATORIES INTERNA 1.04%
BIO TECHNE 0.83%
REPLIGEN 0.64%
BRUKER 0.47%
CAREDX 0.22%
ARCUS BIOSCIENCES 0.15%
BIOHAVEN 0.11%
Only in IBBQ
Royalty Pharma PLC 1.72%
Guardant Health Inc 1.52%
Viatris Inc 1.37%
Jazz Pharmaceuticals PLC 0.99%
Sanofi SA 0.59%
Amneal Pharmaceuticals Inc 0.47%
Ligand Pharmaceuticals Inc 0.41%
Indivior Pharmaceuticals Inc 0.29%

86% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowIBBIBBQIBBIBBQIBBIBBQ
3 months+7.5%+5.3%+4.1 pts+1.9 pts+3.9 pts+1.7 pts
6 months+21.9%+20.0%+6.8 pts+4.9 pts−1.3 pts−3.2 pts
1 year+36.1%+37.2%+18.8 pts+20.0 pts+12.5 pts+13.6 pts
3 years+69.1%+79.7%−16.7 pts−6.1 pts−38.2 pts−27.6 pts
Since launch
IBB Feb 2001 · IBBQ Jun 2021
+525.3%+42.7%−299.7 pts−54.8 pts−936.3 pts−84.7 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

IBB
iShares Biotechnology ETF · Holds 245 stocks in biotech, 40% of its weight in S&P 500 companies
IBBQ
Invesco Nasdaq Biotechnology ETF · Holds 255 stocks in biotech, 40% of its weight in S&P 500 companies
Issuer iShares Invesco
Theme Biotech Biotech
In the S&P 500 39.5% 39.8%
Active share vs the S&P 500 99.0% 99.0%
In the Nasdaq-100 33.1% 32.8%
Holdings 245 255
Top ten, share of the fund 49.9% 46.1%
Expense ratio 0.44% 0.19%
Fee for the differing part 0.44% 0.19%
Total return, 1 year +36.1% +37.2%
vs the S&P 500 +18.8 pts +20.0 pts
vs the Nasdaq-100 +12.5 pts +13.6 pts
Below its high −4.8% −5.3%
Net assets, IBB as of Oct 9, 2026 and IBBQ as of Oct 8, 2026 $10.8bn $108m

As of Oct 9, 2026. Source: ETFIQ.

IBB in plain words

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +36.1% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 18.8 pts.

IBBQ in plain words

By weight, 40% of IBBQ's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 46% of the fund across 255 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +37.2% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 20.0 pts. It sits 5.3% below its all-time high of Aug 19, 2026.

Questions people ask

Do IBB and IBBQ hold the same stocks?
By their latest filings, 86% of their books are the same securities at the same weight, which is close to holding one of them twice. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, IBB or IBBQ?
IBB has 40% of its weight in S&P 500 names and IBBQ has 40%, so IBB differs more from the index.
Which is cheaper, IBB or IBBQ?
IBB charges 0.44% a year and IBBQ charges 0.19%, so IBBQ is cheaper. Fees come from each fund's prospectus.
Other comparisons
IBB vs BBCIBB vs BBHIBB vs PBEIBB vs PBPHIBBQ vs BBHIBBQ vs XBIIBBQ vs PBEIBBQ vs BBP
IBB on its own →IBBQ on its own →How every figure is computed →Standards and sources →
Where these figures came from
IBB filings on SEC EDGAR ↗IBB prospectus with the expense ratio (SEC) ↗iShares page for IBB ↗IBBQ filings on SEC EDGAR ↗IBBQ prospectus with the expense ratio (SEC) ↗Invesco page for IBBQ ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, IBB against IBBQ, data as of Oct 9, 2026. https://etfiq.com/compare/themes/ibb-vs-ibbq

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.