Which ETFs hold Spyre Therapeutics Inc?

67 thematic and core ETFs hold Spyre Therapeutics Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are LFSC at 6.70% of the fund on Aug 31, 2026, XBI at 1.67% of the fund on Nov 3, 2026 and MMSC at 1.16% of the fund on Nov 3, 2026. 2 income and other funds on it are listed apart.

Company · SYRE · listed in US

ETFs that hold Spyre Therapeutics Inc

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67 thematic and core ETFs hold Spyre Therapeutics Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. LFSC holds the most, at 6.70% of the fund on Aug 31, 2026. The next largest are XBI (1.67%) and MMSC (1.16%).

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2 income and other funds on it are listed below.

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Share of each fund · one bar per fund, largest first

LFSC 6.70%67 fundsSPGM <0.01%

funds above 10%

0.18%

median share

funds under 1%

Thematic and core funds that hold it

67 funds

50 of 67 · click a column to sort

ETFs that hold Spyre Therapeutics Inc
#	Fund	Name	Share of the fund ↓	Holdings filed	Asset
1	LFSC	F/m Emerald Life Sciences Innovation ETF	6.70%	Aug 31, 2026	Equity
2	XBI	State Street SPDR S&P Biotech ETF	1.67%	Nov 3, 2026	Equity
3	MMSC	First Trust Multi-Manager Small Cap Opportunities ETF	1.16%	Nov 3, 2026	Equity
4	DWAS	Invesco Dorsey Wright SmallCap Momentum ETF	0.86%	Nov 3, 2026	Equity
5	BBC	Virtus Biotech Clinical Trials ETF	0.81%	Jul 31, 2026	Equity
6	GDOC	Goldman Sachs Future Health Care Equity ETF	0.77%	Aug 31, 2026	Equity
7	SGRW	Harbor Active Small Cap Growth ETF	0.73%	Jul 31, 2026	Equity
8	FDMO	Fidelity Momentum Factor ETF	0.70%	Jul 31, 2026	Equity
9	GSC	Goldman Sachs Small Cap Equity ETF	0.61%	Aug 31, 2026	Equity
10	IBBQ	Invesco Nasdaq Biotechnology ETF	0.56%	Nov 3, 2026	Equity
11	ESSC	Eventide Small Cap ETF	0.55%	Jul 31, 2026	Equity
12	IBB	iShares Biotechnology ETF	0.54%	Nov 3, 2026	Equity
13	FTXH	First Trust Nasdaq Pharmaceuticals ETF	0.52%	Nov 3, 2026	Equity
14	IWO	iShares Russell 2000 Growth ETF	0.51%	Nov 3, 2026	Equity
15	JDOC	JPMorgan Healthcare Leaders ETF	0.50%	Nov 3, 2026	Equity
16	SCDS	JPMorgan Fundamental Data Science Small Core ETF	0.48%	Nov 3, 2026	Equity
17	FMED	Fidelity Disruptive Medicine ETF	0.45%	Aug 31, 2026	Equity
18	VTWG	Vanguard Russell 2000 Growth ETF	0.44%	Sep 30, 2026	Equity
19	CGMM	Capital Group U.S. Small and Mid Cap ETF	0.34%	Aug 31, 2026	Equity
20	TNXT	T. Rowe Price Innovation Leaders ETF	0.33%	Jun 30, 2026	Equity
21	BBSC	JPMorgan BetaBuilders U.S. Small Cap Equity ETF	0.31%	Nov 3, 2026	Equity
22	KBFR	Innovator U.S. Small Cap Managed 10 Buffer ETF	0.29%	Jul 31, 2026	Equity
23	STXK	Strive Small-Cap ETF	0.29%	Jun 30, 2026	Equity
24	BKSE	BNY Mellon US Small Cap Core Equity ETF	0.28%	Jul 31, 2026	Equity
25	PWS	Pacer WealthShield ETF	0.25%	Jul 31, 2026	Equity
26	IWM	iShares Russell 2000 ETF	0.25%	Nov 3, 2026	Equity
27	RUSC	Russell Investments U.S. Small Cap Equity ETF	0.25%	Jun 30, 2026	Equity
28	RFLR	Innovator U.S. Small Cap Managed Floor ETF	0.25%	Jul 31, 2026	Equity
29	RSSL	Global X Russell 2000 ETF	0.23%	Jul 31, 2026	Equity
30	VTWO	Vanguard Russell 2000 ETF	0.22%	Sep 30, 2026	Equity
31	RESM	Columbia Research Enhanced Small Cap ETF	0.22%	Jun 30, 2026	Equity
32	USVM	VictoryShares US Small Mid Cap Value Momentum ETF	0.21%	Jun 30, 2026	Equity
33	TMED	T. Rowe Price Health Care ETF	0.20%	Jun 30, 2026	Equity
34	VFMO	Vanguard U.S. Momentum Factor ETF	0.18%	Sep 30, 2026	Equity
35	MSSM	Morgan Stanley Pathway Small-Mid Cap Equity ETF	0.18%	Aug 31, 2026	Equity
36	VBR	Vanguard Morningstar Small-Cap Value ETF	0.17%	Sep 30, 2026	Equity
37	ISCV	iShares Morningstar Small-Cap Value ETF	0.16%	Nov 3, 2026	Equity
38	SCHA	Schwab U.S. Small-Cap ETF	0.14%	Aug 31, 2026	Equity
39	GSSC	GS ActiveBeta U.S. Small Cap Equity ETF	0.14%	Aug 31, 2026	Equity
40	ISCB	(name not filed)	0.12%	Jul 31, 2026	Equity
41	ESML	iShares ESG Aware MSCI USA Small-Cap ETF	0.10%	Nov 3, 2026	Equity
42	JGRO	JPMorgan Active Growth ETF	0.10%	Nov 3, 2026	Equity
43	VB	Vanguard Morningstar Small-Cap ETF	0.09%	Sep 30, 2026	Equity
44	MSML	iShares MSCI USA Small-Cap ETF	0.09%	Nov 3, 2026	Equity
45	SMLF	iShares U.S. Small-Cap Equity Factor ETF	0.09%	Nov 3, 2026	Equity
46	ISCG	iShares Morningstar Small-Cap Growth ETF	0.09%	Nov 3, 2026	Equity
47	TMSL	T. Rowe Price Small-Mid Cap ETF	0.09%	Jun 30, 2026	Equity
48	VXF	Vanguard Extended Market ETF	0.09%	Sep 30, 2026	Equity
49	FHLC	Fidelity MSCI Health Care Index ETF	0.08%	Jul 31, 2026	Equity
50	VHT	Vanguard Health Care ETF	0.08%	Sep 30, 2026	Equity
51	PRFZ	Invesco RAFI US 1500 Small-Mid ETF	0.06%	Nov 3, 2026	Equity
52	AVIE	Avantis Inflation Focused Equity ETF	0.06%	Nov 2, 2026	Equity
53	WSML	iShares MSCI World Small-Cap ETF	0.06%	Nov 3, 2026	Equity
54	SMMV	iShares MSCI USA Small-Cap Min Vol Factor ETF	0.06%	Nov 3, 2026	Equity
55	ONEQ	Fidelity Nasdaq Composite Index ETF	0.02%	Aug 31, 2026	Equity
56	TILT	Northern Trust Morningstar US Market Factor Tilt ETF	0.02%	Jul 31, 2026	Equity
57	ESGV	Vanguard ESG U.S. Stock ETF	0.01%	Sep 30, 2026	Equity
58	AVLC	Avantis U.S. Large Cap Equity ETF	0.01%	Nov 2, 2026	Equity
59	GUSA	Goldman Sachs MarketBeta U.S. 1000 Equity ETF	0.01%	Aug 31, 2026	Equity
60	ITOT	iShares Core S&P Total U.S. Stock Market ETF	0.01%	Nov 3, 2026	Equity
61	IWV	iShares Russell 3000 ETF	0.01%	Nov 3, 2026	Equity
62	VTI	Vanguard Morningstar Total Stock Market ETF	0.01%	Sep 30, 2026	Equity
63	GTPE	Goldman Sachs MSCI World Private Equity Return Tracker ETF	0.01%	Aug 31, 2026	Equity
64	SCHB	Schwab U.S. Broad Market ETF	0.01%	Aug 31, 2026	Equity
65	VTHR	Vanguard Russell 3000 ETF	0.01%	Sep 30, 2026	Equity
66	VT	Vanguard Total World Stock Index ETF	0.01%	Sep 30, 2026	Equity
67	SPGM	State Street SPDR Portfolio MSCI Global Stock Market ETF	<0.01%	Nov 3, 2026	Equity

As of Nov 5, 2026. Source: each fund's own holdings.

Income and other funds that hold it

#	Fund	Name	Share of the fund	Holdings filed	Category
1	FTKI	First Trust Small Cap BuyWrite Income ETF	0.30%	Nov 3, 2026	Income
2	ITWO	ProShares Russell 2000 High Income ETF	0.19%	Aug 31, 2026	Income

As of Nov 5, 2026. Source: each fund's own holdings.

How we count

Spyre Therapeutics Inc (ticker SYRE, listed in US) is matched in every holdings book ETFIQ publishes, by its ticker and name.

Amber dates are more than a quarter old; the fund may have traded since.

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Themes that hold it: Biotech, Broad innovation and megatrends→

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Questions people ask

Which ETFs hold Spyre Therapeutics Inc?: 67 thematic and core ETFs hold Spyre Therapeutics Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are LFSC at 6.70% of the fund on Aug 31, 2026, XBI at 1.67% of the fund on Nov 3, 2026 and MMSC at 1.16% of the fund on Nov 3, 2026. 2 income and other funds on it are listed apart.

Sources and dates

HoldingsSEC Form N-PORT, what a fund filed it holds ↗

FilingsSEC EDGAR, full-text search of fund filings ↗

Links go to the source documents. ETFIQ is an independent publisher and makes no recommendations. Standards and sources →

Cite this pageCitation, APA and Markdown

ETFIQ, ETFs holding SPYRE THERAPEUTICS INC, data as of Nov 5, 2026. https://etfiq.com/holdings/syre/

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.

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