Data as of .
GNOM vs IBBQ: which is really different?
GNOM and IBBQ hold 20% of their weight in the same names, and GNOM returned more over the year.
ETFIQ Off-Index Score: IBBQ scores higher
How much of it is not the index it is sold as an alternative to?
A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed
20% of the two portfolios are the same securities at the same weight.
What they hold in common
By the books each fund has filed, GNOM and IBBQ hold 20% of their money in the same securities at the same weight.
| Holding | GNOM | IBBQ |
|---|---|---|
| MODERNA INC | 7.99% | 4.10% |
| VERTEX PHARMACEUTICALS INC | 3.35% | 7.98% |
| ILLUMINA INC | 5.30% | 2.43% |
| GILEAD SCIENCES INC | 1.63% | 7.89% |
| GUARDANT HEALTH INC | 5.78% | 1.59% |
| BIOMARIN PHARMACEUTICAL INC | 3.41% | 0.83% |
| BIONTECH SE-ADR | 2.55% | 0.75% |
| TWIST BIOSCIENCE CORP | 7.40% | 0.70% |
| ARROWHEAD PHARMACEUTICALS IN | 2.59% | 0.63% |
| 10X GENOMICS INC-CLASS A | 6.53% | 0.60% |
| CARIS LIFE SCIENCES INC | 2.72% | 0.57% |
| PRAXIS PRECISION MEDICINES I | 2.56% | 0.56% |
| Only in GNOM | Only in IBBQ |
|---|---|
| NATERA INC 5.13% | Amgen Inc 8.05% |
| GENSCRIPT BIOTECH CORP 4.29% | Regeneron Pharmaceuticals Inc 5.42% |
| BIO-TECHNE CORP 3.56% | Revolution Medicines Inc 2.72% |
| QIAGEN N.V. 3.13% | Alnylam Pharmaceuticals Inc 2.14% |
| GENEDX HOLDINGS CORP 1.96% | Biogen Inc 2.13% |
| CAREDX INC 1.85% | Roivant Sciences Ltd 1.92% |
| BILLIONTOONE INC CL A 1.58% | Argenx SE 1.83% |
| ASTRAZENECA PLC 1.23% | Insmed Inc 1.74% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 18, 2026 and Sep 19, 2026.
Performance, window by window
| Window | Total return | vs the S&P 500 | vs the Nasdaq-100 | |||
|---|---|---|---|---|---|---|
| GNOM | IBBQ | GNOM | IBBQ | GNOM | IBBQ | |
| 3 months | +27.6% | +15.8% | +25.4 pts | +13.6 pts | +30.1 pts | +18.3 pts |
| 6 months | +56.4% | +24.9% | +38.4 pts | +6.9 pts | +32.2 pts | +0.7 pts |
| 1 year | +77.5% | +44.6% | +60.9 pts | +28.0 pts | +55.7 pts | +22.8 pts |
| 3 years | +59.3% | +76.7% | −19.1 pts | −1.7 pts | −38.9 pts | −21.5 pts |
| Since launch | +9.8% | +42.0% | −185.2 pts | −51.2 pts | −297.4 pts | −76.1 pts |
| GNOM Global X Genomics & Biotechnology ETF Holds 52 stocks in genomics and gene editing, 21% of its weight in S&P 500 companies | IBBQ Invesco Nasdaq Biotechnology ETF Holds 256 stocks in biotech, 39% of its weight in S&P 500 companies | |
|---|---|---|
| Issuer | Global X | Invesco |
| Theme | Genomics and gene editing | Biotech |
| In the S&P 500 | 20.9% | 38.6% |
| Active share vs the S&P 500 | 97.6% | 99.0% |
| In the Nasdaq-100 | 5.0% | 33.2% |
| Holdings | 52 | 256 |
| Top ten, share of the fund | 52.7% | 44.8% |
| Expense ratio | 0.50% | 0.19% |
| Fee for the differing part | 0.51% | 0.19% |
| Total return, 1 year | +77.5% | +44.6% |
| vs the S&P 500 | +60.9 pts | +28.0 pts |
| vs the Nasdaq-100 | +55.7 pts | +22.8 pts |
| Below its high | −39.6% | −5.8% |
| Net assets | $100m | $96m |
GNOM in plain words
By weight, 21% of GNOM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 53% of the fund across 52 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +77.5% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 60.9 pts. It sits 39.6% below its all-time high of Feb 8, 2021.
IBBQ in plain words
By weight, 39% of IBBQ's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 45% of the fund across 256 positions, as published by its issuer for Sep 19, 2026. Over the year to Sep 18, 2026 the fund returned +44.6% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 28.0 pts. It sits 5.8% below its all-time high of Aug 19, 2026.
Questions people ask
- Do GNOM and IBBQ hold the same stocks?
- By their latest filings, 20% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.
- Which is more different from the S&P 500, GNOM or IBBQ?
- GNOM has 21% of its weight in S&P 500 names and IBBQ has 39%, so IBBQ differs more from the index.
- Which is cheaper, GNOM or IBBQ?
- GNOM charges 0.50% a year and IBBQ charges 0.19%, so IBBQ is cheaper. Fees come from each fund's prospectus.
Other comparisons
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, GNOM against IBBQ, data as of Sep 18, 2026. https://etfiq.com/compare/themes/gnom-vs-ibbq Free to use with attribution; the underlying files are at Open data.