Do GNOM and IBBQ hold the same stocks?

By their latest filings, 21% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, GNOM or IBBQ?

GNOM has 21% of its weight in S&P 500 names and IBBQ has 42%, so IBBQ differs more from the index.

Which is cheaper, GNOM or IBBQ?

GNOM charges 0.50% a year and IBBQ charges 0.19%, so IBBQ is cheaper. Fees come from each fund's prospectus.

Data as of Nov 4, 2026.

Thematic ETFs

GNOM vs IBBQ: Holdings Overlap & Returns

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Over the year to Nov 4, 2026, GNOM returned +66.6% to IBBQ's +42.7%; 21% of their weight is in the same names.

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Net assets: $104m on Oct 12, 2026 for Global X Genomics & Biotechnology ETF, and $121m on Nov 3, 2026 for Invesco Nasdaq Biotechnology ETF.

GNOM on its own →IBBQ on its own →

At a glance

21.0%

GNOM in the S&P 500

42.5%

IBBQ in the S&P 500

+66.6%

GNOM total return, 1 year

+42.7%

IBBQ total return, 1 year

GNOM · 1 year to Nov 4, 2026 79% of its weight is outside the S&P 500

21% of GNOM's weight is in S&P 500 companies and 79% is outside the index. Holdings as of Aug 31, 2026.

IBBQ · 1 year to Nov 4, 2026 58% of its weight is outside the S&P 500

43% of IBBQ's weight is in S&P 500 companies and 58% is outside the index. Holdings as of Nov 3, 2026.

Pair scorecard

IBBQ costs 0.31 points a year less; their one-year returns differ by 23.9 points; IBBQ is 1.1 times larger.

GNOM vs IBBQ: Holdings Overlap & Returns
Measure	GNOM	IBBQ
Return
Measure	GNOM	IBBQ
Total return, 1 year	+66.6%	+42.7%
Drawdown
Measure	GNOM	IBBQ
Below its all-time high	36.2%, high on Feb 8, 2021
Benchmark
Measure	GNOM	IBBQ
What it tracks	Genomics and gene editing	Biotech
Cost and size
Measure	GNOM	IBBQ
Expense ratio	0.50%	0.19%
Net assets, as of Oct 12, 2026	$104m	$111m
Holdings
Measure	GNOM	IBBQ
Holdings in common	21%

Method

Risk and return

Jun 18, 2021 to Oct 30, 2026 · 280 weekly returns

GNOM IBBQ

Return

Total return edge IBBQ −22.5% +52.1%

Annualized edge IBBQ −4.6% +8.1%

Price return edge IBBQ −23.7% +44.3%

Risk

Volatility edge IBBQ 32.0% 21.2%

Max drawdown edge IBBQ −70.6% −35.4%

Risk-adjusted

Sharpe edge IBBQ −0.10 0.30

Sortino edge IBBQ −0.15 0.44

Calmar edge IBBQ −0.07 0.23

Reading

From Jun 2021 to Oct 2026, IBBQ returned more: +52.1% to −22.5%. IBBQ swung less: 21.2% to 32.0%. IBBQ fell less at its worst: −35.4% to −70.6%.

Full scorecard

9 measures, with how each is measured Open ↓

Risk and return: GNOM vs IBBQ: Holdings Overlap & Returns
Measure	GNOM	IBBQ	Edge	How it is measured
Return
Total return	−22.5%	+52.1%	IBBQ	Price change plus distributions, reinvested.
Annualized	−4.6%	+8.1%	IBBQ	Total return as a yearly rate.
Price return	−23.7%	+44.3%	IBBQ	Price change alone, distributions left out.
Risk
Volatility	32.0%	21.2%	IBBQ	Spread of weekly returns, annualized. Lower is steadier.
Downside deviation	22.0%	14.6%	IBBQ	Like volatility, counting only weeks below the Treasury bill rate.
Max drawdown	−70.6%	−35.4%	IBBQ	Deepest fall from a high to the low after it.
Risk-adjusted
Sharpe	−0.10	0.30	IBBQ	Return above Treasury bills per unit of volatility.
Sortino	−0.15	0.44	IBBQ	Return above Treasury bills per unit of downside deviation.
Calmar	−0.07	0.23	IBBQ	Annualized return divided by the max drawdown.

Computed by ETFIQ from Tiingo daily prices and ETFIQ's distribution records, 280 weekly returns. Cash rate: the 13-week Treasury bill.

What they share

21%

By the books each fund has filed, GNOM and IBBQ hold 21% of their money in the same securities at the same weight. Holdings dated Aug 31, 2026 and Nov 3, 2026.

50%

0 half 100%

half

21% in common

Positions both hold · largest shared weight first GNOM IBBQ

MODERNA, INC. 7.50% 5.85%

VERTEX PHARMACEUTICALS INCORPORATED 3.70% 7.65%

ILLUMINA, INC. 4.87% 2.31%

GILEAD SCIENCES, INC. 1.64% 8.97%

GUARDANT HEALTH, INC. 5.28% 1.51%

BIOMARIN PHARMACEUTICAL INC. 3.58% 0.69%

BioNTech SE 2.78% 0.65%

Twist Bioscience Corporation 6.34% 0.60%

CARIS LIFE SCIENCES, INC. 2.38% 0.59%

ARROWHEAD PHARMACEUTICALS, INC. 3.31% 0.54%

10x Genomics, Inc. 5.48% 0.50%

Praxis Precision Medicines, Inc. 3.09% 0.50%

Only in one fund ↓

Only in GNOM

NATERA, INC. 4.61%

Genscript Biotech Corp 3.81%

BIO-TECHNE CORPORATION 3.67%

Qiagen N.V. 3.22%

ELI LILLY AND COMPANY 1.85%

CAREDX, INC. 1.78%

GeneDx Holdings Corp. 1.69%

BillionToOne, Inc. 1.39%

Only in IBBQ

Amgen Inc 8.42%

Regeneron Pharmaceuticals Inc 6.31%

Revolution Medicines Inc 2.67%

Biogen Inc 2.36%

Royalty Pharma PLC 1.90%

Roivant Sciences Ltd 1.67%

United Therapeutics Corp 1.66%

Argenx SE 1.57%

Check overlap with more funds →

Window by window

Window by window: GNOM vs IBBQ: Holdings Overlap & Returns
	Total return
Window	GNOM	IBBQ
3 months	+24.5%	+12.7%
6 months	+49.4%	+23.7%
1 year	+66.6%	+42.7%
3 years	+81.6%	+96.2%
Since launchNot the same days: GNOM Apr 2019 · IBBQ Jun 2021	+16.0%	+51.9%

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Side by side

GNOM Global X Genomics & Biotechnology ETF · Holds 50 stocks in genomics and gene editing, 21% of its weight in S&P 500 companies IBBQ Invesco Nasdaq Biotechnology ETF · Holds 254 stocks in biotech, 42% of its weight in S&P 500 companies

Issuer Global X Invesco

Theme Genomics and gene editing Biotech

In the S&P 500 21.0% 42.5%

Active share vs the S&P 500 97.6% 99.0%

In the Nasdaq-100 5.3% 32.7%

Holdings 50 254

Top ten, share of the fund 48.8% 48.1%

Expense ratio 0.50% 0.19%

Fee for the differing part 0.51% 0.19%

Total return, 1 year +66.6% +42.7%

vs its benchmark not measured not measured

Below its high −36.2% 0.0%

Net assets, GNOM as of Oct 12, 2026 and IBBQ as of Nov 3, 2026 $104m $121m

As of Nov 4, 2026. Source: ETFIQ.

21% of the two portfolios are the same securities at the same weight.

Client brief:

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About each fund

GNOM

By weight, 21% of GNOM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 49% of the fund across 50 positions, as filed for Aug 31, 2026. Over the year to Nov 4, 2026 the fund returned +66.6% with distributions reinvested. It sits 36.2% below its all-time high of Feb 8, 2021.

IBBQ

By weight, 42% of IBBQ's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 48% of the fund across 254 positions, as published by its issuer for Nov 3, 2026. Over the year to Nov 4, 2026 the fund returned +42.7% with distributions reinvested.

Questions people ask

Do GNOM and IBBQ hold the same stocks?: By their latest filings, 21% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, GNOM or IBBQ?: GNOM has 21% of its weight in S&P 500 names and IBBQ has 42%, so IBBQ differs more from the index.
Which is cheaper, GNOM or IBBQ?: GNOM charges 0.50% a year and IBBQ charges 0.19%, so IBBQ is cheaper. Fees come from each fund's prospectus.

Other comparisons

GNOM vs IBB GNOM vs BBP GNOM vs BBC GNOM vs PBE IBBQ vs IDNA IBBQ vs ARKG IBBQ vs GNMX IBBQ vs PBE

Where to next

All thematic ETFs ranked by the S&P 500 Difference Score →How the scores are computed →GNOM on its own →IBBQ on its own →GNOM dividend history →GNOM holdings →IBBQ dividend history →IBBQ holdings →Method →Standards and sources →

Sources and dates

GNOM filings on SEC EDGAR ↗

GNOM prospectus with the expense ratio (SEC) ↗

Global X page for GNOM ↗

IBBQ filings on SEC EDGAR ↗

IBBQ prospectus with the expense ratio (SEC) ↗

Invesco page for IBBQ ↗

Links are sources, not endorsements. A comparison is not a recommendation.

How this is computed

Overlap adds up the smaller of the two weights for each security both funds hold.

Every number is an ETFIQ calculation with distributions reinvested.

Cite this pageCitation, APA and Markdown

ETFIQ, GNOM against IBBQ, data as of Nov 4, 2026. https://etfiq.com/compare/themes/gnom-vs-ibbq

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.