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Data as of .

BBC vs GNOM: which is really different?

BBC and GNOM hold 6% of their weight in the same names, and BBC returned more over the year.

Virtus Biotech Clinical Trials ETF and Global X Genomics & Biotechnology ETF.

0.0%BBC in the S&P 500
20.9%GNOM in the S&P 500
+95.6%BBC total return, 1 year
+77.5%GNOM total return, 1 year

ETFIQ Off-Index Score: BBC scores higher

How much of it is not the index it is sold as an alternative to?

BBC 91.8GNOM 44.50.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

BBC100% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund · 124 holdings filed Apr 30, 2026 · Nasdaq-100: 0% in0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 16% of the fund
GNOM79% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
21%79%in the S&P 500of its weight outside the S&P 500active share 98% · top ten 53% of the fund · 52 holdings filed Sep 18, 2026 · Nasdaq-100: 5% in21%79%inoutside the S&P 500active share 98% · top ten 53% of the fund

6% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, BBC and GNOM hold 6% of their money in the same securities at the same weight.

Positions BBC and GNOM both hold, largest shared weight first
HoldingBBCGNOM
INTELLIA THERAPEUTICS INC1.11%1.03%
VIR BIOTECHNOLOGY INC1.13%0.92%
PRAXIS PRECISION MEDICINES INC0.88%2.56%
BEAM THERAPEUTICS INC0.82%1.75%
UNIQURE NV0.76%1.84%
STOKE THERAPEUTICS INC0.75%1.00%
WAVE LIFE SCIENCES LTD0.32%0.51%
REGENXBIO INC0.48%0.28%
ROCKET PHARMACEUTICALS INC0.76%0.26%
PRIME MEDICINE INC0.64%0.22%
Only in each
Only in BBCOnly in GNOM
ERASCA INC 2.19%MODERNA INC 7.99%
ENLIVEN THERAPEUTICS INC 1.81%TWIST BIOSCIENCE CORP 7.40%
TANGO THERAPEUTICS INC 1.71%10X GENOMICS INC-CLASS A 6.53%
ORUKA THERAPEUTICS INC 1.68%GUARDANT HEALTH INC 5.78%
SPYRE THERAPEUTICS INC 1.64%ILLUMINA INC 5.30%
ALUMIS INC 1.59%NATERA INC 5.13%
DIANTHUS THERAPEUTICS INC 1.54%GENSCRIPT BIOTECH CORP 4.29%
KODIAK SCIENCES INC 1.35%BIO-TECHNE CORP 3.56%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Sep 18, 2026.

Performance, window by window

BBC and GNOM over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
BBCGNOMBBCGNOMBBCGNOM
3 months+6.9%+27.6%+4.7 pts+25.4 pts+9.4 pts+30.1 pts
6 months+22.7%+56.4%+4.7 pts+38.4 pts−1.5 pts+32.2 pts
1 year+95.6%+77.5%+79.0 pts+60.9 pts+73.8 pts+55.7 pts
3 years+143.8%+59.3%+65.3 pts−19.1 pts+45.6 pts−38.9 pts
Since launch+92.6%+9.8%−268.5 pts−185.2 pts−583.0 pts−297.4 pts
Open the live comparison on ETFIQ
BBC and GNOM on the same fields, as of Sep 18, 2026. Source: ETFIQ.
BBC
Virtus Biotech Clinical Trials ETF
Holds 124 stocks in biotech, 0% of its weight in S&P 500 companies
GNOM
Global X Genomics & Biotechnology ETF
Holds 52 stocks in genomics and gene editing, 21% of its weight in S&P 500 companies
IssuerVirtusGlobal X
ThemeBiotechGenomics and gene editing
In the S&P 5000.0%20.9%
Active share vs the S&P 500100.0%97.6%
In the Nasdaq-1000.0%5.0%
Holdings12452
Top ten, share of the fund16.2%52.7%
Expense ratio0.65%0.50%
Fee for the differing part0.65%0.51%
Total return, 1 year+95.6%+77.5%
vs the S&P 500+79.0 pts+60.9 pts
vs the Nasdaq-100+73.8 pts+55.7 pts
Below its high−19.1%−39.6%
Net assets$37m$100m

BBC in plain words

By weight, 0% of BBC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 16% of the fund across 124 positions, as filed for Apr 30, 2026. Over the year to Sep 18, 2026 the fund returned +95.6% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 79.0 pts. It sits 19.1% below its all-time high of Feb 8, 2021.

GNOM in plain words

By weight, 21% of GNOM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 53% of the fund across 52 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +77.5% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 60.9 pts. It sits 39.6% below its all-time high of Feb 8, 2021.

Questions people ask

Do BBC and GNOM hold the same stocks?
By their latest filings, 6% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBC or GNOM?
BBC has 0% of its weight in S&P 500 names and GNOM has 21%, so BBC differs more from the index.
Which is cheaper, BBC or GNOM?
BBC charges 0.65% a year and GNOM charges 0.50%, so GNOM is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

BBC against GNOM, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, BBC against GNOM, data as of Sep 18, 2026. https://etfiq.com/compare/themes/bbc-vs-gnom Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources