Data as of .
FBT vs GNOM: which is really different?
FBT and GNOM hold 26% of their weight in the same names, and GNOM returned more over the year.
ETFIQ Off-Index Score: FBT scores higher
How much of it is not the index it is sold as an alternative to?
A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed
26% of the two portfolios are the same securities at the same weight.
What they hold in common
By the books each fund has filed, FBT and GNOM hold 26% of their money in the same securities at the same weight.
| Holding | FBT | GNOM |
|---|---|---|
| Natera, Inc. | 4.24% | 5.13% |
| Illumina, Inc. | 3.90% | 5.30% |
| BioMarin Pharmaceutical Inc. | 3.35% | 3.41% |
| Vertex Pharmaceuticals Incorporated | 3.24% | 3.35% |
| Bio-Techne Corporation | 3.14% | 3.56% |
| BioNTech SE (ADR) | 3.25% | 2.55% |
| Veracyte, Inc. | 2.16% | 2.33% |
| Gilead Sciences, Inc. | 3.58% | 1.63% |
| Sarepta Therapeutics, Inc. | 3.29% | 1.51% |
| Bruker Corporation | 3.17% | 0.33% |
| Only in FBT | Only in GNOM |
|---|---|
| Halozyme Therapeutics, Inc. 4.57% | MODERNA INC 7.99% |
| NeoGenomics, Inc. 4.37% | TWIST BIOSCIENCE CORP 7.40% |
| Repligen Corporation 3.80% | 10X GENOMICS INC-CLASS A 6.53% |
| Corcept Therapeutics Inc. 3.72% | GUARDANT HEALTH INC 5.78% |
| Genmab A/S (ADR) 3.71% | GENSCRIPT BIOTECH CORP 4.29% |
| Regeneron Pharmaceuticals, Inc. 3.66% | QIAGEN N.V. 3.13% |
| BeOne Medicines Ltd. (ADR) 3.64% | CRISPR THERAPEUTICS AG 2.89% |
| argenx SE (ADR) 3.50% | CARIS LIFE SCIENCES INC 2.72% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 18, 2026.
Performance, window by window
| Window | Total return | vs the S&P 500 | vs the Nasdaq-100 | |||
|---|---|---|---|---|---|---|
| FBT | GNOM | FBT | GNOM | FBT | GNOM | |
| 3 months | +17.2% | +27.6% | +14.9 pts | +25.4 pts | +19.6 pts | +30.1 pts |
| 6 months | +40.6% | +56.4% | +22.6 pts | +38.4 pts | +16.4 pts | +32.2 pts |
| 1 year | +48.9% | +77.5% | +32.3 pts | +60.9 pts | +27.1 pts | +55.7 pts |
| 3 years | +80.7% | +59.3% | +2.3 pts | −19.1 pts | −17.5 pts | −38.9 pts |
| Since launch | +848.2% | +9.8% | +44.6 pts | −185.2 pts | −842.1 pts | −297.4 pts |
| FBT First Trust NYSE Arca Biotechnology Index Fund Holds 31 stocks in biotech, 24% of its weight in S&P 500 companies | GNOM Global X Genomics & Biotechnology ETF Holds 52 stocks in genomics and gene editing, 21% of its weight in S&P 500 companies | |
|---|---|---|
| Issuer | First Trust | Global X |
| Theme | Biotech | Genomics and gene editing |
| In the S&P 500 | 23.6% | 20.9% |
| Active share vs the S&P 500 | 99.1% | 97.6% |
| In the Nasdaq-100 | 16.2% | 5.0% |
| Holdings | 31 | 52 |
| Top ten, share of the fund | 39.2% | 52.7% |
| Expense ratio | 0.55% | 0.50% |
| Fee for the differing part | 0.55% | 0.51% |
| Total return, 1 year | +48.9% | +77.5% |
| vs the S&P 500 | +32.3 pts | +60.9 pts |
| vs the Nasdaq-100 | +27.1 pts | +55.7 pts |
| Below its high | −2.1% | −39.6% |
| Net assets | $2.9bn | $100m |
FBT in plain words
By weight, 24% of FBT's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 39% of the fund across 31 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +48.9% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 32.3 pts.
GNOM in plain words
By weight, 21% of GNOM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 53% of the fund across 52 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +77.5% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 60.9 pts. It sits 39.6% below its all-time high of Feb 8, 2021.
Questions people ask
- Do FBT and GNOM hold the same stocks?
- By their latest filings, 26% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.
- Which is more different from the S&P 500, FBT or GNOM?
- FBT has 24% of its weight in S&P 500 names and GNOM has 21%, so FBT differs more from the index.
- Which is cheaper, FBT or GNOM?
- FBT charges 0.55% a year and GNOM charges 0.50%, so GNOM is cheaper. Fees come from each fund's prospectus.
Other comparisons
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, FBT against GNOM, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fbt-vs-gnom Free to use with attribution; the underlying files are at Open data.