Data as of .
GNOM vs PBPH: which is really different?
GNOM and PBPH hold 9% of their weight in the same names.
ETFIQ Off-Index Score: GNOM scores higher
How much of it is not the index it is sold as an alternative to?
A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed
9% of the two portfolios are the same securities at the same weight.
What they hold in common
By the books each fund has filed, GNOM and PBPH hold 9% of their money in the same securities at the same weight.
| Holding | GNOM | PBPH |
|---|---|---|
| ELI LILLY & CO | 1.79% | 14.74% |
| GILEAD SCIENCES INC | 1.63% | 4.10% |
| ASTRAZENECA PLC | 1.23% | 4.60% |
| BRISTOL-MYERS SQUIBB CO | 0.95% | 2.61% |
| NATERA INC | 5.13% | 0.71% |
| BIOMARIN PHARMACEUTICAL INC | 3.41% | 0.24% |
| Only in GNOM | Only in PBPH |
|---|---|
| MODERNA INC 7.99% | JOHNSON & JOHNSON 9.10% |
| TWIST BIOSCIENCE CORP 7.40% | ABBVIE INC 6.53% |
| 10X GENOMICS INC-CLASS A 6.53% | ROCHE HOLDING AG-GENUSSCHEIN 5.28% |
| GUARDANT HEALTH INC 5.78% | NOVARTIS AG-REG 4.99% |
| ILLUMINA INC 5.30% | MERCK & CO. INC. 4.71% |
| GENSCRIPT BIOTECH CORP 4.29% | NOVO NORDISK A/S-B 4.37% |
| BIO-TECHNE CORP 3.56% | AMGEN INC 4.33% |
| VERTEX PHARMACEUTICALS INC 3.35% | PFIZER INC 3.48% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jan 31, 2026 and Sep 18, 2026.
Performance, window by window
| Window | Total return | vs the S&P 500 | vs the Nasdaq-100 | |||
|---|---|---|---|---|---|---|
| GNOM | PBPH | GNOM | PBPH | GNOM | PBPH | |
| 3 months | +27.6% | +12.4% | +25.4 pts | +10.1 pts | +30.1 pts | +14.8 pts |
| 6 months | +56.4% | +15.6% | +38.4 pts | −2.5 pts | +32.2 pts | −8.7 pts |
| 1 year | +77.5% | not published | +60.9 pts | not published | +55.7 pts | not published |
| 3 years | +59.3% | not published | −19.1 pts | not published | −38.9 pts | not published |
| Since launch | +9.8% | +13.3% | −185.2 pts | −0.8 pts | −297.4 pts | −5.7 pts |
| GNOM Global X Genomics & Biotechnology ETF Holds 52 stocks in genomics and gene editing, 21% of its weight in S&P 500 companies | PBPH Portfolio Building Block World Pharma and Biotech Index ETF Holds 51 stocks in biotech, 57% of its weight in S&P 500 companies | |
|---|---|---|
| Issuer | Global X | Portfolio Building Block |
| Theme | Genomics and gene editing | Biotech |
| In the S&P 500 | 20.9% | 56.8% |
| Active share vs the S&P 500 | 97.6% | 95.0% |
| In the Nasdaq-100 | 5.0% | 14.7% |
| Holdings | 52 | 51 |
| Top ten, share of the fund | 52.7% | 62.7% |
| Expense ratio | 0.50% | 0.13% |
| Fee for the differing part | 0.51% | 0.14% |
| Total return, 1 year | +77.5% | +13.3% (since launch on Nov 25, 2025) |
| vs the S&P 500 | +60.9 pts | −0.8 pts |
| vs the Nasdaq-100 | +55.7 pts | −5.7 pts |
| Below its high | −39.6% | −4.8% |
| Net assets | $100m | $36m |
GNOM in plain words
By weight, 21% of GNOM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 53% of the fund across 52 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +77.5% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 60.9 pts. It sits 39.6% below its all-time high of Feb 8, 2021.
PBPH in plain words
By weight, 57% of PBPH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 63% of the fund across 51 positions, as filed for Jan 31, 2026. Since it launched on Nov 25, 2025 the fund returned +13.3% with distributions reinvested against +14.1% for the S&P 500, so a holder was behind by 0.8 pts.
Questions people ask
- Do GNOM and PBPH hold the same stocks?
- By their latest filings, 9% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
- Which is more different from the S&P 500, GNOM or PBPH?
- GNOM has 21% of its weight in S&P 500 names and PBPH has 57%, so GNOM differs more from the index.
- Which is cheaper, GNOM or PBPH?
- GNOM charges 0.50% a year and PBPH charges 0.13%, so PBPH is cheaper. Fees come from each fund's prospectus.
Other comparisons
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, GNOM against PBPH, data as of Sep 18, 2026. https://etfiq.com/compare/themes/gnom-vs-pbph Free to use with attribution; the underlying files are at Open data.