Do GNOM and PBPH hold the same stocks?

By their latest filings, 9% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, GNOM or PBPH?

GNOM has 21% of its weight in S&P 500 names and PBPH has 59%, so GNOM differs more from the index.

Which is cheaper, GNOM or PBPH?

GNOM charges 0.50% a year and PBPH charges 0.13%, so PBPH is cheaper. Fees come from each fund's prospectus.

Data as of Nov 4, 2026.

Thematic ETFs

GNOM vs PBPH: Holdings Overlap & Returns

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GNOM and PBPH hold 9% of their weight in the same names.

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Net assets: $104m on Oct 12, 2026 for Global X Genomics & Biotechnology ETF, and $952m on Jul 31, 2026 for Portfolio Building Block World Pharma and Biotech Index ETF.

GNOM on its own →PBPH on its own →

At a glance

21.0%

GNOM in the S&P 500

59.2%

PBPH in the S&P 500

+66.6%

GNOM total return, 1 year

+27.0%

PBPH total return, since launch, Nov 25, 2025

GNOM · 1 year to Nov 4, 2026 79% of its weight is outside the S&P 500

21% of GNOM's weight is in S&P 500 companies and 79% is outside the index. Holdings as of Aug 31, 2026.

PBPH · 6 months to Nov 4, 2026 41% of its weight is outside the S&P 500

59% of PBPH's weight is in S&P 500 companies and 41% is outside the index. Holdings as of Jul 31, 2026.

Pair scorecard

PBPH costs 0.37 points a year less.

GNOM vs PBPH: Holdings Overlap & Returns
Measure	GNOM	PBPH
Return
Measure	GNOM	PBPH
Total return, 1 year	+66.6%	not published
Drawdown
Measure	GNOM	PBPH
Below its all-time high	36.2%, high on Feb 8, 2021
Benchmark
Measure	GNOM	PBPH
What it tracks	Genomics and gene editing	Biotech
Cost and size
Measure	GNOM	PBPH
Expense ratio	0.50%	0.13%
Net assets, GNOM as of Oct 12, 2026 and PBPH as of Jul 31, 2026	$104m	$952m
Holdings
Measure	GNOM	PBPH
Holdings in common	9%

Method

What they share

By the books each fund has filed, GNOM and PBPH hold 9% of their money in the same securities at the same weight. Holdings dated Jul 31, 2026 and Aug 31, 2026.

50%

0 half 100%

half

9% in common

Positions both hold · largest shared weight first GNOM PBPH

VERTEX PHARMACEUTICALS INCORPORATED 3.70% 2.82%

GILEAD SCIENCES, INC. 1.64% 3.77%

ASTRAZENECA PLC 1.23% 3.90%

BRISTOL-MYERS SQUIBB COMPANY 1.04% 3.11%

NATERA, INC. 4.61% 0.85%

ILLUMINA, INC. 4.87% 0.72%

MODERNA, INC. 7.50% 0.45%

BIOMARIN PHARMACEUTICAL INC. 3.58% 0.27%

Only in one fund ↓

Only in GNOM

Twist Bioscience Corporation 6.34%

10x Genomics, Inc. 5.48%

GUARDANT HEALTH, INC. 5.28%

Genscript Biotech Corp 3.81%

BIO-TECHNE CORPORATION 3.67%

ARROWHEAD PHARMACEUTICALS, INC. 3.31%

Qiagen N.V. 3.22%

Praxis Precision Medicines, Inc. 3.09%

Only in PBPH

ELI LILLY & COMPANY 15.20%

JOHNSON & JOHNSON 9.66%

ABBVIE INC 6.94%

MERCK & COMPANY INC 5.04%

ROCHE HOLDING AG 4.74%

AMGEN INC 4.63%

NOVARTIS AG 4.47%

NOVO NORDISK A/S 3.51%

Check overlap with more funds →

Window by window

Window by window: GNOM vs PBPH: Holdings Overlap & Returns
	Total return
Window	GNOM	PBPH
3 months	+24.5%	+16.2%
6 months	+49.4%	+25.6%
1 year	+66.6%	–
3 years	+81.6%	–
Since launchNot the same days: GNOM Apr 2019 · PBPH Nov 2025	+16.0%	+27.0%

– means no data for this window. Open this comparison in the app →

Side by side

GNOM Global X Genomics & Biotechnology ETF · Holds 50 stocks in genomics and gene editing, 21% of its weight in S&P 500 companies PBPH Portfolio Building Block World Pharma and Biotech Index ETF · Holds 53 stocks in biotech, 59% of its weight in S&P 500 companies

Issuer Global X Portfolio Building Block

Theme Genomics and gene editing Biotech

In the S&P 500 21.0% 59.2%

Active share vs the S&P 500 97.6% 95.0%

In the Nasdaq-100 5.3% 13.6%

Holdings 50 53

Top ten, share of the fund 48.8% 61.9%

Expense ratio 0.50% 0.13%

Fee for the differing part 0.51% 0.14%

Total return, 1 year +66.6% +27.0% (since launch, Nov 25, 2025)

vs its benchmark not measured not measured

Below its high −36.2% 0.0%

Net assets, GNOM as of Oct 12, 2026 and PBPH as of Jul 31, 2026 $104m $952m

As of Nov 4, 2026. Source: ETFIQ.

9% of the two portfolios are the same securities at the same weight.

Alert

About each fund

GNOM

By weight, 21% of GNOM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 49% of the fund across 50 positions, as filed for Aug 31, 2026. Over the year to Nov 4, 2026 the fund returned +66.6% with distributions reinvested. It sits 36.2% below its all-time high of Feb 8, 2021.

PBPH

By weight, 59% of PBPH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 62% of the fund across 53 positions, as filed for Jul 31, 2026. Since it first traded on Nov 25, 2025 the fund returned +27.0% with distributions reinvested.

Questions people ask

Do GNOM and PBPH hold the same stocks?: By their latest filings, 9% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, GNOM or PBPH?: GNOM has 21% of its weight in S&P 500 names and PBPH has 59%, so GNOM differs more from the index.
Which is cheaper, GNOM or PBPH?: GNOM charges 0.50% a year and PBPH charges 0.13%, so PBPH is cheaper. Fees come from each fund's prospectus.

Other comparisons

GNOM vs PBE GNOM vs FBT GNOM vs XBI GNOM vs IBB PBPH vs IDNA PBPH vs ARKG PBPH vs GNMX PBPH vs IBBQ

Where to next

All thematic ETFs ranked by the S&P 500 Difference Score →How the scores are computed →GNOM on its own →PBPH on its own →GNOM dividend history →GNOM holdings →PBPH dividend history →PBPH holdings →Method →Standards and sources →

Sources and dates

GNOM filings on SEC EDGAR ↗

GNOM prospectus with the expense ratio (SEC) ↗

Global X page for GNOM ↗

PBPH filings on SEC EDGAR ↗

PBPH prospectus with the expense ratio (SEC) ↗

Portfolio Building Block page for PBPH ↗

Links are sources, not endorsements. A comparison is not a recommendation.

How this is computed

Overlap adds up the smaller of the two weights for each security both funds hold.

Every number is an ETFIQ calculation with distributions reinvested.

Cite this pageCitation, APA and Markdown

ETFIQ, GNOM against PBPH, data as of Nov 4, 2026. https://etfiq.com/compare/themes/gnom-vs-pbph

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.