Get the weekly note
ETFIQetfiq.com · independent ETF data

Data as of .

ARKG vs PBPH: which is really different?

ARKG and PBPH hold 4% of their weight in the same names.

ARK Genomic Revolution ETF and Portfolio Building Block World Pharma and Biotech Index ETF.

3.5%ARKG in the S&P 500
56.8%PBPH in the S&P 500
+87.1%ARKG total return, 1 year
+13.3%PBPH total return, 1 year

ETFIQ Off-Index Score: ARKG scores higher

How much of it is not the index it is sold as an alternative to?

ARKG 55.9PBPH 32.10.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

ARKG97% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
4%97%inof its weight outside the S&P 500active share 99% · top ten 60% of the fund · 33 holdings filed Sep 18, 2026 · Nasdaq-100: 0% in4%97%4% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 60% of the fund
PBPH43% of its weight is outside the S&P 500 · 6 months to Sep 18, 2026
57%43%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 95% · top ten 63% of the fund · 51 holdings filed Jan 31, 2026 · Nasdaq-100: 15% in57%43%in the S&P 500outsideactive share 95% · top ten 63% of the fund

4% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, ARKG and PBPH hold 4% of their money in the same securities at the same weight.

Positions ARKG and PBPH both hold, largest shared weight first
HoldingARKGPBPH
ELI LILLY & CO3.51%14.74%
NATERA INC4.25%0.71%
IONIS PHARMACEUTICALS INC1.60%0.32%
Only in each
Only in ARKGOnly in PBPH
TWIST BIOSCIENCE CORP 9.63%JOHNSON & JOHNSON 9.10%
10X GENOMICS INC-CLASS A 9.39%ABBVIE INC 6.53%
TEMPUS AI INC-CL A 8.92%ROCHE HOLDING AG-GENUSSCHEIN 5.28%
CRISPR THERAPEUTICS AG 5.63%NOVARTIS AG-REG 4.99%
PERSONALIS INC 5.16%MERCK & CO. INC. 4.71%
GUARDANT HEALTH INC 4.87%ASTRAZENECA PLC 4.60%
ABSCI CORP 4.76%NOVO NORDISK A/S-B 4.37%
ILLUMINA INC 4.13%AMGEN INC 4.33%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jan 31, 2026 and Sep 21, 2026.

Performance, window by window

ARKG and PBPH over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
ARKGPBPHARKGPBPHARKGPBPH
3 months+40.1%+12.4%+37.9 pts+10.1 pts+42.6 pts+14.8 pts
6 months+98.2%+15.6%+80.2 pts−2.5 pts+74.0 pts−8.7 pts
1 year+87.1%not published+70.6 ptsnot published+65.4 ptsnot published
3 years+74.8%not published−3.6 ptsnot published−23.4 ptsnot published
Since launch+174.6%+13.3%−186.8 pts−0.8 pts−504.0 pts−5.7 pts
Open the live comparison on ETFIQ
ARKG and PBPH on the same fields, as of Sep 18, 2026. Source: ETFIQ.
ARKG
ARK Genomic Revolution ETF
Holds 33 stocks in genomics and gene editing, 4% of its weight in S&P 500 companies
PBPH
Portfolio Building Block World Pharma and Biotech Index ETF
Holds 51 stocks in biotech, 57% of its weight in S&P 500 companies
IssuerARKPortfolio Building Block
ThemeGenomics and gene editingBiotech
In the S&P 5003.5%56.8%
Active share vs the S&P 50098.5%95.0%
In the Nasdaq-1000.0%14.7%
Holdings3351
Top ten, share of the fund60.4%62.7%
Expense ratio0.75%0.13%
Fee for the differing part0.76%0.14%
Total return, 1 year+87.1%+13.3% (since launch on Nov 25, 2025)
vs the S&P 500+70.6 pts−0.8 pts
vs the Nasdaq-100+65.4 pts−5.7 pts
Below its high−53.8%−4.8%
Net assets$2.2bn$36m

ARKG in plain words

By weight, 4% of ARKG's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 60% of the fund across 33 positions, as published by its issuer for Sep 21, 2026. Over the year to Sep 18, 2026 the fund returned +87.1% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 70.6 pts. It sits 53.8% below its all-time high of Jan 20, 2021.

PBPH in plain words

By weight, 57% of PBPH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 63% of the fund across 51 positions, as filed for Jan 31, 2026. Since it launched on Nov 25, 2025 the fund returned +13.3% with distributions reinvested against +14.1% for the S&P 500, so a holder was behind by 0.8 pts.

Questions people ask

Do ARKG and PBPH hold the same stocks?
By their latest filings, 4% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, ARKG or PBPH?
ARKG has 4% of its weight in S&P 500 names and PBPH has 57%, so ARKG differs more from the index.
Which is cheaper, ARKG or PBPH?
ARKG charges 0.75% a year and PBPH charges 0.13%, so PBPH is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

ARKG against PBPH, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, ARKG against PBPH, data as of Sep 18, 2026. https://etfiq.com/compare/themes/arkg-vs-pbph Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources