Is there a biotech ETF?
Yes.
ETFIQ covers 10 biotech ETFs as of Oct 20, 2026. The largest is IBB at $10.9bn. The cheapest is PBPH at 0.13%.
How much of a biotech fund is already in the S&P 500 decides how much of it is new exposure. Across these 10 funds the median is 31.3% of the weight. The rest is what you are buying that an index fund does not already hold.
Concentration is the other thing to read. The median biotech ETF here holds 47.6% of its weight in its top ten positions. That is what a theme fund does: it buys a shortlist, not a market.
ETFIQ files a fund under a theme editorially, from what the fund holds rather than from its name, and every figure on this page is the one its biotech hub prints.
On ETFIQ today
| Ticker | Fund | Issuer | Net assets | Fee | In the S&P 500 |
|---|---|---|---|---|---|
| IBB | iShares Biotechnology ETF | iShares | $10.9bn | 0.44% | 40.8% |
| XBI | State Street SPDR S&P Biotech ETF | State Street | $10.4bn | 0.35% | 13.6% |
| FBT | First Trust NYSE Arca Biotechnology Index Fu | First Trust | $3.0bn | 0.55% | 23.7% |
| PBPH | Portfolio Building Block World Pharma and Bi | Portfolio Building Block | $952m | 0.13% | 59.2% |
| BBH | VanEck Biotech ETF | VanEck | $488m | 0.35% | 62.6% |
| PBE | Invesco Biotechnology & Genome ETF | Invesco | $431m | 0.59% | 31.3% |
| IBBQ | Invesco Nasdaq Biotechnology ETF | Invesco | $115m | 0.19% | 41.3% |
| BBP | Virtus Biotech ETF | Virtus | $99m | 0.34% | 10.5% |
| BBC | Virtus Biotech Clinical Trials ETF | Virtus | $46m | 0.65% | 0.0% |
| TDNA | T. Rowe Price Biotech ETF | T. Rowe Price | $10m | 0.55% | not yet filed |
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