Do GNMX and XBI hold the same stocks?

By their latest filings, 27% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, GNMX or XBI?

GNMX has 29% of its weight in S&P 500 names and XBI has 13%, so GNMX differs more from the index.

Which is cheaper, GNMX or XBI?

GNMX and XBI both charge 0.35% a year, so neither is cheaper. Fees come from each fund's prospectus.

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GNMX vs XBI: which is really different?

GNMX and XBI hold 27% of their weight in the same names. Corgi Genomics & Precision Medicine ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.

Both cost 0.35% a year; XBI is far larger, $9.9bn against $1m.

	GNMX	XBI
Expense ratio	0.35%	0.35%
Net assets, GNMX as of Oct 9, 2026 and XBI as of Oct 8, 2026	$1m	$9.9bn
Total return, 1 year	not published	+45.0%
What it tracks	Genomics and gene editing	Biotech
Holdings in common	27%
S&P 500, total return, since May 6, 2026	+6.6%
S&P 500, total return, 1 year		+17.3%
Against the S&P 500, since May 6, 2026	ahead by 39.3 pts
Against the S&P 500, 1 year		ahead by 27.7 pts
Below its all-time high		11.1%, high on Feb 8, 2021

Holdings in common uses holdings dated Oct 8, 2026 and Oct 9, 2026.

28.7%

GNMX in the S&P 500

12.7%

XBI in the S&P 500

+45.9%

GNMX total return, since launch

+45.0%

XBI total return, 1 year

GNMX · 3 months to Oct 9, 202671% of its weight is outside the S&P 500

29% of GNMX's weight is in S&P 500 companies and 71% is outside the index. Holdings as of Oct 9, 2026.

XBI · 1 year to Oct 9, 202687% of its weight is outside the S&P 500

13% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · GNMX scores higherHow much of it is not the index it is sold as an alternative to?

GNMX 68.8

XBI 55.2

0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, GNMX and XBI hold 27% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Oct 8, 2026 and Oct 9, 2026.

50%

half

27% in common

Positions both hold, largest shared weight first

Holding GNMX XBI

Moderna Inc 9.96% 2.20%

Twist Bioscience Corp 2.64% 1.84%

Iovance Biotherapeutics Inc 3.17% 1.54%

Vertex Pharmaceuticals Inc 5.71% 1.47%

Krystal Biotech Inc 1.77% 1.43%

Revolution Medicines Inc 3.14% 1.37%

Incyte Corp 2.53% 1.36%

CRISPR Therapeutics AG 1.34% 1.41%

GRAIL Inc 2.25% 1.33%

Alnylam Pharmaceuticals Inc 2.48% 1.32%

BioMarin Pharmaceutical Inc 1.84% 1.29%

Ionis Pharmaceuticals Inc 1.16% 1.17%

Only in GNMX

Thermo Fisher Scientific Inc 8.42%

Illumina Inc 4.90%

10X Genomics Inc 3.48%

Guardant Health Inc 3.48%

Genmab A/S 3.00%

Bio-Techne Corp 2.13%

QIAGEN NV 1.89%

Tempus AI Inc 1.78%

Only in XBI

NATERA INC 1.79%

ABBVIE INC 1.65%

UNITED THERAPEUTICS CORP 1.59%

AMGEN INC 1.58%

BIOGEN INC 1.57%

HALOZYME THERAPEUTICS INC 1.55%

EXELIXIS INC 1.53%

GILEAD SCIENCES INC 1.53%

27% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	GNMX	XBI	GNMX	XBI	GNMX	XBI
3 months	+21.0%	−3.3%	+17.6 pts	−6.7 pts	+17.4 pts	−7.0 pts
6 months	not published	+18.9%	not published	+3.8 pts	not published	−4.3 pts
1 year	not published	+45.0%	not published	+27.7 pts	not published	+21.4 pts
3 years	not published	+114.6%	not published	+28.8 pts	not published	+7.3 pts
Since launch GNMX May 2026 · XBI Feb 2006	+45.9%	+890.7%	+39.3 pts	+92.2 pts	+37.7 pts	−1,164.7 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

GNMX

Corgi Genomics & Precision Medicine ETF · Holds 57 stocks in genomics and gene editing, 29% of its weight in S&P 500 companies

XBI

State Street(R) SPDR(R) S&P(R) Biotech ETF · Holds 165 stocks in biotech, 13% of its weight in S&P 500 companies

Issuer Corgi State Street

Theme Genomics and gene editing Biotech

In the S&P 500 28.7% 12.7%

Active share vs the S&P 500 99.4% 98.4%

In the Nasdaq-100 8.2% 8.5%

Holdings 57 165

Top ten, share of the fund 47.9% 16.9%

Expense ratio 0.35% 0.35%

Fee for the differing part 0.35% 0.36%

Total return, 1 year +45.9% (since it first traded on May 6, 2026) +45.0%

vs the S&P 500 +39.3 pts +27.7 pts

vs the Nasdaq-100 +37.7 pts +21.4 pts

Below its high −4.3% −11.1%

Net assets, GNMX as of Oct 9, 2026 and XBI as of Oct 8, 2026 $1m $9.9bn

As of Oct 9, 2026. Source: ETFIQ.

GNMX in plain words

By weight, 29% of GNMX's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 48% of the fund across 57 positions, as published by its issuer for Oct 9, 2026. Since it first traded on May 6, 2026 the fund returned +45.9% with distributions reinvested against +6.6% for the S&P 500, so a holder was ahead by 39.3 pts.

XBI in plain words

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 17% of the fund across 165 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +45.0% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 27.7 pts. It sits 11.1% below its all-time high of Feb 8, 2021.

Questions people ask

Do GNMX and XBI hold the same stocks?: By their latest filings, 27% of their books are the same securities at the same weight, which is a meaningful overlap. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, GNMX or XBI?: GNMX has 29% of its weight in S&P 500 names and XBI has 13%, so GNMX differs more from the index.
Which is cheaper, GNMX or XBI?: GNMX and XBI both charge 0.35% a year, so neither is cheaper. Fees come from each fund's prospectus.

Other comparisons

GNMX vs IBB GNMX vs FBT GNMX vs PBPH GNMX vs IBBQ XBI vs GNOM XBI vs IDNA XBI vs ARKG XBI vs IDEF

GNMX on its own →XBI on its own →How every figure is computed →Standards and sources →

Where these figures came from

GNMX filings on SEC EDGAR ↗GNMX prospectus with the expense ratio (SEC) ↗Corgi website ↗XBI filings on SEC EDGAR ↗XBI prospectus with the expense ratio (SEC) ↗State Street website ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, GNMX against XBI, data as of Oct 9, 2026. https://etfiq.com/compare/themes/gnmx-vs-xbi

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.