Get the weekly note

Data as of Sep 13, 2026. Both funds on the fields they both publish, from the same sources.

ETFIQetfiq.com · independent ETF data

GRNY vs XBI: how they differ

GRNY and XBI hold 0% of their weight in the same names, and XBI returned more over the year.

Fundstrat Granny Shots US Large Cap ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.

What they hold in common

By the books each fund has filed, GRNY and XBI hold 0% of their money in the same securities at the same weight.

Largest positions each one holds and the other does not
Only in GRNYOnly in XBI
Advanced Micro Devices Inc 4.17%MODERNA INC 2.87%
Quanta Services Inc 3.20%TWIST BIOSCIENCE CORP 1.81%
GE Vernova Inc 3.05%HALOZYME THERAPEUTICS INC 1.47%
Amazon.com Inc 3.02%NATERA INC 1.46%
Strategy Inc 3.01%KYMERA THERAPEUTICS INC 1.45%
Alphabet Inc 2.96%TRAVERE THERAPEUTICS INC 1.40%
Broadcom Inc 2.94%ROIVANT SCIENCES LTD 1.39%
Arista Networks Inc 2.88%ORUKA THERAPEUTICS INC 1.38%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Sep 10, 2026.

GRNY and XBI on the fields both publish, as of Sep 13, 2026. Source: ETFIQ.
GRNY
Fundstrat Granny Shots US Large Cap ETF
XBI
State Street(R) SPDR(R) S&P(R) Biotech ETF
Where it sitsCore index fundCore index fund
IssuerFundstratState Street
What it isFundstrat Granny Shots US Large CapSPDR S&P Biotech
Total return, 1 year+13.8%+64.0%
S&P 500 over the same days+17.5%+17.5%
Gap to the S&P 500−3.7 pts+46.5 pts
Expense ratio0.75%0.35%
Already in the S&P 50097.0%8.5%
Holdings40154

GRNY in plain words

GRNY is an index equity fund tracking the Fundstrat Granny Shots US Large Cap. Over the year to Sep 11, 2026 it returned +13.8% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.75% a year. By its holdings filed for Apr 30, 2026, 97% of the fund by weight is stocks the S&P 500 also holds, across 40 positions, with the top ten at 30.8%.

XBI in plain words

XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Sep 10, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 154 positions, with the top ten at 15.9%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.

Questions people ask

Which returned more over the last year, GRNY or XBI?
In the year to Sep 13, 2026, with distributions reinvested, GRNY returned +13.8% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
Which is cheaper, GRNY or XBI?
GRNY charges 0.75% a year and XBI charges 0.35%, so XBI is cheaper. Fees come from each fund's prospectus.
How much do GRNY and XBI overlap with the S&P 500?
By their latest filed holdings, 97% of GRNY and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 0% of their books are the same securities at the same weight.

Other comparisons

Where to next

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

GRNY against XBI, ETFIQ, data as of Sep 13, 2026. Every figure is arithmetic on a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, GRNY against XBI, data as of Sep 13, 2026. https://etfiq.com/compare/any/grny-vs-xbi Free to use with attribution; the underlying files are at Open data.

A comparison is not a recommendation. Standards and sources