Data as of Sep 13, 2026. Both funds on the fields they both publish, from the same sources.
XBI vs XLG: how they differ
XBI and XLG hold 1% of their weight in the same names, and XBI returned more over the year.
State Street(R) SPDR(R) S&P(R) Biotech ETF and Invesco S&P 500 Top 50 ETF.
What they hold in common
By the books each fund has filed, XBI and XLG hold 1% of their money in the same securities at the same weight.
| Holding | XBI | XLG |
|---|---|---|
| ABBVIE INC | 1.09% | 1.09% |
| Only in XBI | Only in XLG |
|---|---|
| MODERNA INC 2.87% | NVIDIA Corp 12.79% |
| TWIST BIOSCIENCE CORP 1.81% | Apple Inc 11.58% |
| HALOZYME THERAPEUTICS INC 1.47% | Microsoft Corp 8.83% |
| NATERA INC 1.46% | Amazon.com Inc 5.95% |
| KYMERA THERAPEUTICS INC 1.45% | Alphabet Inc 4.71% |
| TRAVERE THERAPEUTICS INC 1.40% | Broadcom Inc 4.12% |
| ROIVANT SCIENCES LTD 1.39% | Alphabet Inc 3.77% |
| ORUKA THERAPEUTICS INC 1.38% | Meta Platforms Inc 3.42% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 10, 2026.
| XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | XLG Invesco S&P 500 Top 50 ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | State Street | Invesco |
| What it is | SPDR S&P Biotech | S&P 500 top 50 |
| Total return, 1 year | +64.0% | +12.2% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +46.5 pts | −5.3 pts |
| Expense ratio | 0.35% | 0.20% |
| Already in the S&P 500 | 8.5% | 100.0% |
| Holdings | 154 | 52 |
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Sep 10, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 154 positions, with the top ten at 15.9%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
XLG in plain words
XLG is an index equity fund tracking the S&P 500 top 50. Over the year to Sep 11, 2026 it returned +12.2% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.20% a year. By its holdings filed for Sep 10, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 52 positions, with the top ten at 60.3%.
Questions people ask
- Which returned more over the last year, XBI or XLG?
- In the year to Sep 13, 2026, with distributions reinvested, XBI returned +64.0% and XLG returned +12.2%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, XBI or XLG?
- XBI charges 0.35% a year and XLG charges 0.20%, so XLG is cheaper. Fees come from each fund's prospectus.
- How much do XBI and XLG overlap with the S&P 500?
- By their latest filed holdings, 8% of XBI and 100% of XLG by weight is stocks the S&P 500 already holds. Between the two funds, 1% of their books are the same securities at the same weight.
Other comparisons
Where to next
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, XBI against XLG, data as of Sep 13, 2026. https://etfiq.com/compare/any/xbi-vs-xlg Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources