Data as of Oct 27, 2026.
Healthcare innovation ETFs
See every healthcare innovation ETF by what it holds, not by its name. Funds that hold the companies changing how healthcare is delivered, including the makers of the GLP-1 weight loss drugs and digital health businesses. 8 funds, largest first. Updated Oct 27, 2026. The typical fund carries 35% of its weight in S&P 500 stocks, the 21st most of the 53 themes with holdings on file.
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What these funds actually own
Between them the 8 funds' ten largest holdings name 61 companies, of which 16 appear in more than one.More
Eli Lilly & Co is among the ten largest of 4 of them, at an average of 8.3% of the fund.
Healthcare innovation and GLP-1 ETFs, the companies their ten largest holdings name. The 15 most widely held of 61. Source: each fund's latest SEC filing or its issuer’s own daily holdings file, read by ETFIQ.
How this is counted
Each row counts the ten largest holdings of each fund, so a fund missing from a row may still hold that company lower down. Weights are of the funds that name it, not of the theme.
Share of each fund's weight in S&P 500 companies. Above half, the fund is mostly the S&P 500.
Dark line: the S&P 500 over the same days, +13.5%. Last column: the gap to each fund's own benchmark, in points.
The 8 largest healthcare innovation ETFs
ETFIQ covers 8 healthcare innovation ETFs. The largest are OZEM ($54m), HELX ($35m) and HEAL ($31m); fees run 0.45% to 0.85%, as of .
- 1OZEM$54m0.59%Roundhill GLP-1 & Weight Loss ETF
- 2HELX$35m0.50%Franklin Genomic Advancements ETF
- 3HEAL$31m0.50%Global X HealthTech ETF
- 4BMED$14m0.55%iShares Health Innovation Active ETF
- 5EKG$9.6m0.65%First Trust Nasdaq Lux Digital Health Solutions ETF
- 6THNR$5.7m0.59%Amplify Weight Loss Drug & Treatment ETF
- 7WDNA$2.7m0.45%WisdomTree BioRevolution Fund
- 8LGHT$2.5m0.85%Langar Global HealthTech ETF
Every healthcare innovation ETF, largest first
Click a column to sort| Ticker | Fund | Issuer | Net assets ↓ | In the S&P 500 | Active share | Total return 1Y | vs its benchmark 1Y | Fee |
|---|---|---|---|---|---|---|---|---|
| OZEM | Roundhill GLP-1 & Weight Loss ETF | Roundhill | $54m | 30.1% | 97.8% | +6.8% | not measured | 0.59% |
| HELX | Franklin Genomic Advancements ETF | Franklin | $35m | 14.9% | 97.2% | +28.9% | not measured | 0.50% |
| HEAL | Global X HealthTech ETF | Global X | $31m | 28.8% | 99.5% | −6.4% | not measured | 0.50% |
| BMED | iShares Health Innovation Active ETF | iShares | $14m | 57.7% | 95.6% | +24.8% | not measured | 0.55% |
| EKG | First Trust Nasdaq Lux Digital Health Solutions ETF | First Trust | $9.6m | 40.5% | 99.6% | +31.1% | not measured | 0.65% |
| THNR | Amplify Weight Loss Drug & Treatment ETF | Amplify | $5.7m | 45.1% | 96.5% | +8.1% | not measured | 0.59% |
| WDNA | WisdomTree BioRevolution Fund | WisdomTree | $2.7m | 25.9% | 95.3% | +44.5% | not measured | 0.45% |
| LGHT | Langar Global HealthTech ETF | Langar | $2.5m | 57.9% | 99.5% | +4.3% | not measured | 0.85% |
How much of each pair is the same fund
The closest pair is OZEM and THNR, which hold 68% of their weight in the same companies. The furthest apart is LGHT and THNR at 0%. The middle pair of the 28 is 8%.
Healthcare innovation ETFs, the share of each pair’s weight held in the same companies. Read across or down; the number is the same either way. Cells are shaded against the closest pair here, 68%. Source: each fund’s own filed or daily holdings, read by ETFIQ.
How to read the grid
Weight overlap adds the smaller of the two weights for every company both funds hold. Funds with a cut-short book are left out, not compared short.
What each fund holds alone
Healthcare innovation ETFs, the largest holding no other fund in the grid holds. Source: ETFIQ.
Questions people ask
- How many healthcare innovation ETFs are there?
- ETFIQ covers 8 US listed healthcare innovation ETFs as of Oct 27, 2026. That is every one it can measure from the fund’s own published holdings.
- What is the largest healthcare innovation ETF?
- OZEM, Roundhill GLP-1 & Weight Loss ETF, at $54m in net assets as of Oct 27, 2026, the largest of the 8 healthcare innovation ETFs with a published size.
- What is the cheapest healthcare innovation ETF?
- WDNA, WisdomTree BioRevolution Fund, at 0.45% a year by its prospectus filed Oct 28, 2025, the lowest fee of the 8 healthcare innovation ETFs that publish one.
- Which healthcare innovation ETF has performed best over the past year?
- WDNA, WisdomTree BioRevolution Fund, at +44.5% total return over the year to Oct 27, 2026, the highest of the 8 healthcare innovation ETFs with a full year of trading behind them. Past returns do not predict future ones.
- What do healthcare innovation ETFs hold?
- Funds that hold the companies changing how healthcare is delivered, including the makers of the GLP-1 weight loss drugs and digital health businesses. Between them the 8 healthcare innovation ETFs ETFIQ can read name 61 companies in their ten largest holdings, by holdings dated May 31, 2026 to Oct 27, 2026, most widely Eli Lilly & Co, which is among the ten largest of 4 of them.
- Do healthcare innovation ETFs hold the same companies?
- It depends which two. Across the 28 pairs of the 8 healthcare innovation ETFs with a full published book, by holdings dated May 31, 2026 to Oct 27, 2026, OZEM and THNR hold 68% of their weight in the same companies, LGHT and THNR hold 0%, and the middle pair holds 8%. Two funds sold on one theme are not the same fund.
What the issuers say about this theme
About these links
The issuers behind these healthcare innovation funds publish their own work on this theme. These are their pages and words, not ETFIQ’s. A fund company writing about a theme it sells is making a case.
Issuer material on this theme. Links leave ETFIQ. Source: each issuer’s own site.
Links are sources, not endorsements. Standards and sources →
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<figure style="margin:0;max-width:640px">
<a href="https://etfiq.com/themes/health-innovation"><img src="https://etfiq.com/assistant/api/embed/theme/health-innovation.svg" alt="Healthcare innovation and GLP-1 ETFs, one-year total return to Oct 27, 2026: WDNA +44.5%, EKG +31.1%, HELX +28.9%, BMED +24.8%, THNR +8.1%, OZEM +6.8%, LGHT +4.3%, HEAL −6.4%." width="640" style="max-width:100%;height:auto"></a>
<figcaption style="font:13px/1.5 sans-serif">Healthcare innovation and GLP-1 ETFs, one-year total return to Oct 27, 2026: WDNA +44.5%, EKG +31.1%, HELX +28.9%, BMED +24.8%, THNR +8.1%, OZEM +6.8%, LGHT +4.3%, HEAL −6.4%. Data: <a href="https://etfiq.com/themes/health-innovation">ETFIQ</a></figcaption>
</figure>Cite this pageCitation, APA and Markdown
ETFIQ, Healthcare innovation ETFs, data as of Oct 27, 2026. https://etfiq.com/themes/health-innovation
ETFIQ. (Oct 27, 2026). Healthcare innovation ETFs. Retrieved from https://etfiq.com/themes/health-innovation
[Healthcare innovation ETFs (ETFIQ, Oct 27, 2026)](https://etfiq.com/themes/health-innovation)
Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.