Ranked by net assets, as of . Rebuilt every trading night.
The largest healthcare innovation ETFs
Every fund here is sold on healthcare innovation. What each one holds, and how much of it the S&P 500 already holds for you, is the column beside the size.
| # | Ticker | Fund | Net assets | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
|---|---|---|---|---|---|---|---|
| 1 | OZEM | Roundhill GLP-1 & Weight Loss ETF | $54m | 24.8% | +21.1% | 0.59% | SEC filing, whole fund |
| 2 | HELX | Franklin Genomic Advancements ETF | $28m | 15.1% | +33.6% | 0.50% | SEC filing, whole fund |
| 3 | HEAL | Global X HealthTech ETF | $25m | 26.8% | −12.8% | 0.50% | SEC filing, whole fund |
| 4 | BMED | iShares Health Innovation Active ETF | $10m | 60.8% | +23.6% | 0.55% | SEC filing, whole fund |
| 5 | THNR | Amplify Weight Loss Drug & Treatment ETF | $4m | 33.3% | +11.3% | 0.59% | SEC filing, whole fund |
| 6 | EKG | First Trust Nasdaq Lux Digital Health So | $3m | 42.4% | +21.3% | 0.65% | SEC filing, whole fund |
| 7 | WDNA | WisdomTree BioRevolution Fund | $3m | 25.9% | +56.1% | 0.45% | SEC filing, whole fund |
| 8 | LGHT | Langar Global HealthTech ETF | $2m | 69.6% | −6.1% | 0.85% | SEC filing, whole fund |
Method
The 8 ETFs in the healthcare innovation and glp-1 theme, of which 8 publish net assets, ranked on the most recent figure for each. Across the funds listed here the weight held in S&P 500 companies runs from 15.1% to 69.6%. Size is not a measure of anything a fund did. It is where the money is. The ranking is the published field sorted, nothing else: no scoring, no weighting and no view on any fund. Every fund ETFIQ covers in this category is eligible, including funds that have closed, because leaving them out would flatter the category.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
A ranking is not a recommendation and no order on this site is an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources
Cite this page. ETFIQ, The largest healthcare innovation ETFs, ranked by net assets, data as of Sep 11, 2026. https://etfiq.com/rankings/themes-largest-health-innovation Free to use with attribution; the underlying files are at Open data.