As of Oct 27, 2026. Rebuilt every trading night.
The largest healthcare innovation ETFs
See 8 funds ranked by net assets. Updated Oct 27, 2026. Every fund here is sold on healthcare innovation. The column beside the size shows how much of each the S&P 500 already holds.
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All 8, highest first
8 of 8 · click a column to sort| # | Ticker | Fund | Net assets ↓ | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
|---|---|---|---|---|---|---|---|
| 1 | OZEM | Roundhill GLP-1 & Weight Loss ETF | $54m | 30.1% | +6.8% | 0.59% | Issuer daily, Oct 27, 2026 |
| 2 | HELX | Franklin Genomic Advancements ETF | $35m | 14.9% | +28.9% | 0.50% | Issuer page, Oct 26, 2026 |
| 3 | HEAL | Global X HealthTech ETF | $31m | 28.8% | −6.4% | 0.50% | Issuer page, Oct 12, 2026 |
| 4 | BMED | iShares Health Innovation Active ETF | $14m | 57.7% | +24.8% | 0.55% | Issuer daily, Oct 27, 2026 |
| 5 | EKG | First Trust Nasdaq Lux Digital Health So | $9.6m | 40.5% | +31.1% | 0.65% | Issuer page, Oct 26, 2026 |
| 6 | THNR | Amplify Weight Loss Drug & Treatment ETF | $5.7m | 45.1% | +8.1% | 0.59% | Issuer page, Oct 26, 2026 |
| 7 | WDNA | WisdomTree BioRevolution Fund | $2.7m | 25.9% | +44.5% | 0.45% | SEC filing, Jun 30, 2026 |
| 8 | LGHT | Langar Global HealthTech ETF | $2.5m | 57.9% | +4.3% | 0.85% | SEC filing, Jun 30, 2026 |
The 8 ETFs in the healthcare innovation and glp-1 theme, of which 8 publish net assets, ranked on the most recent number for each.
The rest of the method
Across the funds listed here the weight held in S&P 500 companies runs from 14.9% to 57.9%. Size shows where the money is, not what a fund did. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
Links are sources, not endorsements. A ranking is not a recommendation or an opinion.
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ETFIQ, The largest healthcare innovation ETFs, ranked by net assets, data as of Oct 27, 2026. https://etfiq.com/rankings/themes-largest-health-innovation
ETFIQ. (Oct 27, 2026). The largest healthcare innovation ETFs, ranked by net assets. Retrieved from https://etfiq.com/rankings/themes-largest-health-innovation
[The largest healthcare innovation ETFs, ranked by net assets (ETFIQ, Oct 27, 2026)](https://etfiq.com/rankings/themes-largest-health-innovation)
Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.