The thematic ETFs least like the S&P 500

See 15 funds ranked by active share against the S&P 500, latest holdings filing. Updated Oct 27, 2026. Different is not better. It is how much of the fund a holder did not already own through the index. The top 15 are level at 100.0%, so their order is not a ranking. None of them holds anything the S&P 500 holds.

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Active share, one bar per fund

firstlast

100.0%

first, PDBA

100.0%

last, RNRG

funds in the list

All 15, highest first

15 of 15 · click a column to sort

Points (pts) are percentage points.

The thematic ETFs least like the S&P 500
#	Ticker	Fund	Theme	Active share ↓	In the S&P 500	Total return 1Y	vs its benchmark 1Y
1	PDBA	Invesco Agriculture Commodity Strategy No K-1 ETF	Agriculture	100.0%	0.0%	+8.2%	not measured
2	DRAI	Draco Evolution AI ETF	Artificial intelligence	100.0%	0.0%	+7.5%	−5.4 pts vs GUSA
3	DRGN	Themes China Generative Artificial Intelligence ETF	Artificial intelligence	100.0%	0.0%	−20.7%	−33.8 pts vs ACWI
4	KAIT	KraneShares Asia AI Technology ETF	Artificial intelligence	100.0%	0.0%	not published	not available
5	BBC	Virtus Biotech Clinical Trials ETF	Biotech	100.0%	0.0%	+36.6%	not measured
6	GXDW	Global X Dorsey Wright Thematic ETF	Broad innovation and megatrends	100.0%	0.0%	−10.8%	not measured
7	LFSC	F/m Emerald Life Sciences Innovation ETF	Broad innovation and megatrends	100.0%	0.0%	+35.8%	+22.7 pts vs IWV
8	MJ	Amplify Alternative Harvest ETF	Cannabis	100.0%	0.0%	−32.6%	not measured
9	MSOS	AdvisorShares Pure US Cannabis ETF	Cannabis	100.0%	0.0%	−12.0%	not measured
10	WEED	Roundhill Cannabis ETF	Cannabis	100.0%	0.0%	−1.5%	not measured
11	YOLO	AdvisorShares Pure Cannabis ETF	Cannabis	100.0%	0.0%	−21.1%	not measured
12	CTEC	Global X ClimateTech ETF	Clean energy	100.0%	7.1%	−10.0%	not measured
13	ICLN	iShares Global Clean Energy ETF	Clean energy	100.0%	8.2%	−4.3%	not measured
14	KGRN	KraneShares MSCI China Clean Technology Index ETF	Clean energy	100.0%	0.0%	−30.9%	not measured
15	RNRG	Global X Renewable Energy Producers ETF	Clean energy	100.0%	0.0%	−5.1%	−18.2 pts vs ACWI

As of Oct 27, 2026. Source: ETFIQ.CSV Method

Method

Active share is one hundred minus the weight overlap with the S&P 500 book, computed by ETFIQ from filed holdings.

The rest of the method

The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

How these numbers are computed →Standards and sources →

Where to next

Every thematic ETF414 →The thematic ETFs that are mostly the index already15 →

Sources and dates

Fund holdings from SEC Form N-PORT and from the issuers’ own daily filessec.gov ↗

SEC EDGAR, full-text search of fund filingsefts.sec.gov ↗

SEC Form N-PORT, what a fund filed it holdssec.gov ↗

Rule 19a-1, what a distribution notice must sayecfr.gov ↗

Links are sources, not endorsements. A ranking is not a recommendation or an opinion.

Cite this pageCitation, APA and Markdown

ETFIQ, The thematic ETFs least like the S&P 500, ranked by active share against the S&P 500, data as of Oct 27, 2026. https://etfiq.com/rankings/themes-least-index

Open data →

Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.