The healthcare innovation ETFs that returned most
See 8 funds ranked by total return with distributions reinvested, one year. Updated Oct 20, 2026. Funds on one theme can hold different companies, so the gap from top to bottom of this list reflects what they own, not the theme.
Ask IQ about this page
Ask IQ about the healthcare innovation ETFs that returned mostAnswers cite the figures on this page.
| # | Ticker | Fund | Total return, 1Y ↓ | vs its benchmark 1Y | Weight in S&P 500 companies | Fee |
|---|---|---|---|---|---|---|
| 1 | WDNA | WisdomTree BioRevolution Fund | +36.0% | not measured | 25.9% | 0.45% |
| 2 | EKG | First Trust Nasdaq Lux Digital Health So | +31.2% | not measured | 41.4% | 0.65% |
| 3 | BMED | iShares Health Innovation Active ETF | +25.4% | not measured | 58.4% | 0.55% |
| 4 | HELX | Franklin Genomic Advancements ETF | +25.1% | not measured | 14.9% | 0.50% |
| 5 | LGHT | Langar Global HealthTech ETF | +10.1% | not measured | 57.9% | 0.85% |
| 6 | OZEM | Roundhill GLP-1 & Weight Loss ETF | +8.8% | not measured | 29.3% | 0.59% |
| 7 | THNR | Amplify Weight Loss Drug & Treatment ETF | +7.8% | not measured | 44.8% | 0.59% |
| 8 | HEAL | Global X HealthTech ETF | −6.1% | not measured | 28.8% | 0.50% |
Method
The 8 of 8 ETFs in the healthcare innovation and glp-1 theme with a full year of trading, highest first, each over the same year to Oct 20, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from -6.1% to 36.0%.
The rest of the method
A year says what happened, not what happens next. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
ETFIQ links to the documents behind every figure; a link is not an endorsement. A ranking is not a recommendation or an opinion.
Cite this pageCitation, APA and Markdown
ETFIQ, The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-health-innovation
ETFIQ. (Oct 20, 2026). The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested. Retrieved from https://etfiq.com/rankings/themes-best-year-health-innovation
[The healthcare innovation ETFs that returned most, ranked by total return with distributions reinvested (ETFIQ, Oct 20, 2026)](https://etfiq.com/rankings/themes-best-year-health-innovation)
Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.