The healthcare innovation ETFs least like the index
See 8 funds ranked by the share of the fund by weight that is held in S&P 500 companies. Updated Oct 20, 2026. Every fund here is sold on healthcare innovation, and they differ in how much of the index they hand you back. The one at the top is the one adding the most that is new.
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Ask IQ about the healthcare innovation ETFs least like the indexAnswers cite the figures on this page.
| # | Ticker | Fund | Weight in S&P 500 companies ↑ | Active share | Net assets | Fee |
|---|---|---|---|---|---|---|
| 1 | HELX | Franklin Genomic Advancements ETF | 14.9% | 97.2% | $34m | 0.50% |
| 2 | WDNA | WisdomTree BioRevolution Fund | 25.9% | 95.3% | $3m | 0.45% |
| 3 | HEAL | Global X HealthTech ETF | 28.8% | 99.5% | $31m | 0.50% |
| 4 | OZEM | Roundhill GLP-1 & Weight Loss ETF | 29.3% | 97.8% | $56m | 0.59% |
| 5 | EKG | First Trust Nasdaq Lux Digital Health So | 41.4% | 99.6% | $10m | 0.65% |
| 6 | THNR | Amplify Weight Loss Drug & Treatment ETF | 44.8% | 96.5% | $6m | 0.59% |
| 7 | LGHT | Langar Global HealthTech ETF | 57.9% | 99.5% | $2m | 0.85% |
| 8 | BMED | iShares Health Innovation Active ETF | 58.4% | 95.6% | $14m | 0.55% |
Method
The 8 of 8 ETFs in the healthcare innovation and glp-1 theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date.
The rest of the method
Across the funds listed here the weight held in S&P 500 companies runs from 14.9% to 58.4%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
ETFIQ links to the documents behind every figure; a link is not an endorsement. A ranking is not a recommendation or an opinion.
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ETFIQ, The healthcare innovation ETFs least like the index, ranked by the share of the fund by weight that is held in S&P 500 companies, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-off-index-health-innovation
ETFIQ. (Oct 20, 2026). The healthcare innovation ETFs least like the index, ranked by the share of the fund by weight that is held in S&P 500 companies. Retrieved from https://etfiq.com/rankings/themes-off-index-health-innovation
[The healthcare innovation ETFs least like the index, ranked by the share of the fund by weight that is held in S&P 500 companies (ETFIQ, Oct 20, 2026)](https://etfiq.com/rankings/themes-off-index-health-innovation)
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