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The biotech ETFs least like the S&P 500
Every fund here is sold on biotech, and they differ in how much of the index they hand you back. The one at the top is the one adding the most that is new.
| # | Ticker | Fund | Weight in S&P 500 companies | Active share | Net assets | Fee |
|---|---|---|---|---|---|---|
| 1 | BBC | Virtus Biotech Clinical Trials ETF | 0.0% | 100.0% | $37m | 0.65% |
| 2 | BBP | Virtus Biotech ETF | 12.4% | 99.0% | $59m | 0.34% |
| 3 | FBT | First Trust NYSE Arca Biotechnology Inde | 23.6% | 99.1% | $2.9bn | 0.55% |
| 4 | PBE | Invesco Biotechnology & Genome ETF | 30.0% | 99.0% | $414m | 0.59% |
| 5 | IBBQ | Invesco Nasdaq Biotechnology ETF | 38.6% | 99.0% | $96m | 0.19% |
| 6 | PBPH | Portfolio Building Block World Pharma an | 56.8% | 95.0% | $36m | 0.13% |
| 7 | BBH | VanEck Biotech ETF | 60.4% | 99.0% | $498m | 0.35% |
Method
The 7 of 7 ETFs in the biotech theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date. Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 60.4%. A thematic fund is worth its fee only for the part of it you do not already own. The ranking is the published field sorted, nothing else: no scoring, no weighting and no view on any fund. Every fund ETFIQ covers in this category is eligible, including funds that have closed, because leaving them out would flatter the category.
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Where these figures came from
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A ranking is not a recommendation and no order on this site is an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources
Cite this page. ETFIQ, The biotech ETFs least like the S&P 500, ranked by the share of the fund by weight that is held in S&P 500 companies, data as of Sep 18, 2026. https://etfiq.com/rankings/themes-off-index-biotech Free to use with attribution; the underlying files are at Open data.