As of Nov 4, 2026. Rebuilt every trading night.
The biotech ETFs least like the S&P 500
See 9 funds ranked by the share of each fund held in S&P 500 companies. Updated Nov 4, 2026. Every fund here is sold on biotech. The one at the top holds the least of the S&P 500, so it adds the most you do not already own.
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All 9, lowest first
9 of 9 · click a column to sort| # | Ticker | Fund | Weight in S&P 500 companies ↑ | Active share | Net assets | Fee |
|---|---|---|---|---|---|---|
| 1 | BBC | Virtus Biotech Clinical Trials ETF | 0.0% | 100.0% | $46m | 0.65% |
| 2 | BBP | Virtus Biotech ETF | 10.5% | 99.0% | $99m | 0.34% |
| 3 | XBI | State Street SPDR S&P Biotech ETF | 13.9% | 98.4% | $10.6bn | 0.35% |
| 4 | FBT | First Trust NYSE Arca Biotechnology Inde | 24.8% | 99.1% | $3.1bn | 0.55% |
| 5 | PBE | Invesco Biotechnology & Genome ETF | 32.3% | 99.0% | $442m | 0.59% |
| 6 | IBB | iShares Biotechnology ETF | 42.0% | 99.0% | $11.2bn | 0.44% |
| 7 | IBBQ | Invesco Nasdaq Biotechnology ETF | 42.5% | 99.0% | $121m | 0.19% |
| 8 | PBPH | Portfolio Building Block World Pharma an | 59.2% | 95.0% | $952m | 0.13% |
| 9 | BBH | VanEck Biotech ETF | 64.4% | 99.0% | $525m | 0.35% |
The 9 of 10 ETFs in the biotech theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date.
The rest of the method
Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 64.4%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
Links are sources, not endorsements. A ranking is not a recommendation or an opinion.
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ETFIQ, The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-biotech
ETFIQ. (Nov 4, 2026). The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies. Retrieved from https://etfiq.com/rankings/themes-off-index-biotech
[The biotech ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-off-index-biotech)
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