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The largest biotech ETFs
Every fund here is sold on biotech. What each one holds, and how much of it the S&P 500 already holds for you, is the column beside the size.
| # | Ticker | Fund | Net assets | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
|---|---|---|---|---|---|---|---|
| 1 | FBT | First Trust NYSE Arca Biotechnology Inde | $2.9bn | 23.6% | +48.9% | 0.55% | Issuer page, Sep 18, 2026 |
| 2 | BBH | VanEck Biotech ETF | $498m | 60.4% | +40.5% | 0.35% | Issuer holdings, Sep 17, 2026 |
| 3 | PBE | Invesco Biotechnology & Genome ETF | $414m | 30.0% | +36.2% | 0.59% | Issuer holdings, Sep 19, 2026 |
| 4 | IBBQ | Invesco Nasdaq Biotechnology ETF | $96m | 38.6% | +44.6% | 0.19% | Issuer holdings, Sep 19, 2026 |
| 5 | BBP | Virtus Biotech ETF | $59m | 12.4% | +47.5% | 0.34% | SEC filing, Apr 30, 2026 |
| 6 | BBC | Virtus Biotech Clinical Trials ETF | $37m | 0.0% | +95.6% | 0.65% | SEC filing, Apr 30, 2026 |
| 7 | PBPH | Portfolio Building Block World Pharma an | $36m | 56.8% | too new | 0.13% | SEC filing, Jan 31, 2026 |
Method
The 7 ETFs in the biotech theme, of which 7 publish net assets, ranked on the most recent figure for each. Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 60.4%. Size is not a measure of anything a fund did. It is where the money is. The ranking is the published field sorted, nothing else: no scoring, no weighting and no view on any fund. Every fund ETFIQ covers in this category is eligible, including funds that have closed, because leaving them out would flatter the category.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
A ranking is not a recommendation and no order on this site is an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources
Cite this page. ETFIQ, The largest biotech ETFs, ranked by net assets, data as of Sep 18, 2026. https://etfiq.com/rankings/themes-largest-biotech Free to use with attribution; the underlying files are at Open data.