The largest biotech ETFs

See 10 funds ranked by net assets. Updated Nov 4, 2026. Every fund here is sold on biotech. The column beside the size shows how much of each the S&P 500 already holds.

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Net assets, one bar per fund

firstlast

$11.2bn

first, IBB

$11m

last, TDNA

funds in the list

All 10, highest first

10 of 10 · click a column to sort

The largest biotech ETFs
#	Ticker	Fund	Net assets ↓	Weight in S&P 500 companies	Total return, 1Y	Fee	Source
1	IBB	iShares Biotechnology ETF	$11.2bn	42.0%	+42.0%	0.44%	Issuer daily, Nov 3, 2026
2	XBI	State Street SPDR S&P Biotech ETF	$10.6bn	13.9%	+47.9%	0.35%	Issuer daily, Nov 3, 2026
3	FBT	First Trust NYSE Arca Biotechnology Inde	$3.1bn	24.8%	+47.0%	0.55%	Issuer page, Nov 3, 2026
4	PBPH	Portfolio Building Block World Pharma an	$952m	59.2%	too new	0.13%	SEC filing, Jul 31, 2026
5	BBH	VanEck Biotech ETF	$525m	64.4%	+47.2%	0.35%	Issuer holdings, Nov 3, 2026
6	PBE	Invesco Biotechnology & Genome ETF	$442m	32.3%	+44.2%	0.59%	Issuer page, Nov 3, 2026
7	IBBQ	Invesco Nasdaq Biotechnology ETF	$121m	42.5%	+42.7%	0.19%	Issuer page, Nov 3, 2026
8	BBP	Virtus Biotech ETF	$99m	10.5%	+44.4%	0.34%	SEC filing, Jul 31, 2026
9	BBC	Virtus Biotech Clinical Trials ETF	$46m	0.0%	+45.9%	0.65%	SEC filing, Jul 31, 2026
10	TDNA	T. Rowe Price Biotech ETF	$11m	not yet filed	too new	0.55%	Issuer page, Nov 3, 2026

As of Nov 4, 2026. Source: ETFIQ.CSV Method

Method

The 10 ETFs in the biotech theme, of which 10 publish net assets, ranked on the most recent number for each.

The rest of the method

Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 64.4%. Size shows where the money is, not what a fund did. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

How these numbers are computed →Standards and sources →

Where to next

Every biotech ETF and what it holds→The thematic ETFs least like the S&P 50015 →

Sources and dates

Fund holdings from SEC Form N-PORT and from the issuers’ own daily filessec.gov ↗

SEC EDGAR, full-text search of fund filingsefts.sec.gov ↗

SEC Form N-PORT, what a fund filed it holdssec.gov ↗

Rule 19a-1, what a distribution notice must sayecfr.gov ↗

Links are sources, not endorsements. A ranking is not a recommendation or an opinion.

Cite this pageCitation, APA and Markdown

ETFIQ, The largest biotech ETFs, ranked by net assets, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-largest-biotech

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.