As of Nov 4, 2026. Rebuilt every trading night.
The most concentrated biotech ETFs
See 9 funds ranked by the share of the fund held in its ten largest positions. Updated Nov 4, 2026. Two funds on one theme can hold ten names or two hundred. Fund names do not show which.
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All 9, highest first
9 of 9 · click a column to sort| # | Ticker | Fund | Top ten weight ↓ | Holdings | Net assets | Total return, 1Y |
|---|---|---|---|---|---|---|
| 1 | BBH | VanEck Biotech ETF | 73.5% | 25 | $525m | +47.2% |
| 2 | PBPH | Portfolio Building Block World Pharma an | 61.9% | 53 | $952m | too new |
| 3 | IBB | iShares Biotechnology ETF | 51.6% | 245 | $11.2bn | +42.0% |
| 4 | PBE | Invesco Biotechnology & Genome ETF | 49.1% | 32 | $442m | +44.2% |
| 5 | IBBQ | Invesco Nasdaq Biotechnology ETF | 48.1% | 254 | $121m | +42.7% |
| 6 | FBT | First Trust NYSE Arca Biotechnology Inde | 38.2% | 30 | $3.1bn | +47.0% |
| 7 | BBP | Virtus Biotech ETF | 19.6% | 67 | $99m | +44.4% |
| 8 | XBI | State Street SPDR S&P Biotech ETF | 18.1% | 165 | $10.6bn | +47.9% |
| 9 | BBC | Virtus Biotech Clinical Trials ETF | 11.8% | 131 | $46m | +45.9% |
The 9 of 10 ETFs in the biotech theme with a filed book, most concentrated first.
The rest of the method
Across the funds listed here the weight in the ten largest runs from 11.8% to 73.5%. Concentration is not a fault. It shows how much rides on ten holdings. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
Links are sources, not endorsements. A ranking is not a recommendation or an opinion.
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ETFIQ, The most concentrated biotech ETFs, ranked by the share of the fund held in its ten largest positions, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-concentrated-biotech
ETFIQ. (Nov 4, 2026). The most concentrated biotech ETFs, ranked by the share of the fund held in its ten largest positions. Retrieved from https://etfiq.com/rankings/themes-concentrated-biotech
[The most concentrated biotech ETFs, ranked by the share of the fund held in its ten largest positions (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-concentrated-biotech)
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