As of Nov 4, 2026. Rebuilt every trading night.
The cheapest biotech ETFs
See 10 funds ranked by the annual fee the fund charges. Updated Nov 4, 2026. A fee is one fact, not a verdict. Funds on one theme can hold different companies, and the holdings are on the theme page.
askIQ about this page
askIQ about the cheapest biotech ETFs
All 10, lowest first
10 of 10 · click a column to sort| # | Ticker | Fund | Fee ↑ | Net assets | Weight in S&P 500 companies | Total return, 1Y |
|---|---|---|---|---|---|---|
| 1 | PBPH | Portfolio Building Block World Pharma an | 0.13% | $952m | 59.2% | too new |
| 2 | IBBQ | Invesco Nasdaq Biotechnology ETF | 0.19% | $121m | 42.5% | +42.7% |
| 3 | BBP | Virtus Biotech ETF | 0.34% | $99m | 10.5% | +44.4% |
| 4 | BBH | VanEck Biotech ETF | 0.35% | $525m | 64.4% | +47.2% |
| 5 | XBI | State Street SPDR S&P Biotech ETF | 0.35% | $10.6bn | 13.9% | +47.9% |
| 6 | IBB | iShares Biotechnology ETF | 0.44% | $11.2bn | 42.0% | +42.0% |
| 7 | FBT | First Trust NYSE Arca Biotechnology Inde | 0.55% | $3.1bn | 24.8% | +47.0% |
| 8 | TDNA | T. Rowe Price Biotech ETF | 0.55% | $11m | not yet filed | too new |
| 9 | PBE | Invesco Biotechnology & Genome ETF | 0.59% | $442m | 32.3% | +44.2% |
| 10 | BBC | Virtus Biotech Clinical Trials ETF | 0.65% | $46m | 0.0% | +45.9% |
The 10 of 10 ETFs in the biotech theme that publish an expense ratio, cheapest first. Across the funds listed here the annual fee runs from 0.1% to 0.7%.
The rest of the method
A fee is the one number a fund controls and the one a holder always pays. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
Links are sources, not endorsements. A ranking is not a recommendation or an opinion.
Cite this pageCitation, APA and Markdown
ETFIQ, The cheapest biotech ETFs, ranked by the annual fee the fund charges, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-cheapest-biotech
ETFIQ. (Nov 4, 2026). The cheapest biotech ETFs, ranked by the annual fee the fund charges. Retrieved from https://etfiq.com/rankings/themes-cheapest-biotech
[The cheapest biotech ETFs, ranked by the annual fee the fund charges (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-cheapest-biotech)
Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.