As of . Rebuilt every trading night.
The biotech ETFs that returned most
Funds sold on one theme can hold different companies, so a year apart at the top and the bottom of this list is a difference in what they own rather than in the theme.
| # | Ticker | Fund | Total return, 1Y | vs the S&P 500 | Weight in S&P 500 companies | Fee |
|---|---|---|---|---|---|---|
| 1 | BBC | Virtus Biotech Clinical Trials ETF | +95.6% | +79.0 pts | 0.0% | 0.65% |
| 2 | FBT | First Trust NYSE Arca Biotechnology Inde | +48.9% | +32.3 pts | 23.6% | 0.55% |
| 3 | BBP | Virtus Biotech ETF | +47.5% | +30.9 pts | 12.4% | 0.34% |
| 4 | IBBQ | Invesco Nasdaq Biotechnology ETF | +44.6% | +28.0 pts | 38.6% | 0.19% |
| 5 | BBH | VanEck Biotech ETF | +40.5% | +23.9 pts | 60.4% | 0.35% |
| 6 | PBE | Invesco Biotechnology & Genome ETF | +36.2% | +19.6 pts | 30.0% | 0.59% |
Method
The 6 of 7 ETFs in the biotech theme with a full year of trading, highest first, each over the same year to Sep 18, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from 36.2% to 95.6%. A year is a year. It says what happened and nothing about what happens next. The ranking is the published field sorted, nothing else: no scoring, no weighting and no view on any fund. Every fund ETFIQ covers in this category is eligible, including funds that have closed, because leaving them out would flatter the category.
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Where these figures came from
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Cite this page. ETFIQ, The biotech ETFs that returned most, ranked by total return with distributions reinvested, data as of Sep 18, 2026. https://etfiq.com/rankings/themes-best-year-biotech Free to use with attribution; the underlying files are at Open data.