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Company · SEPN · listed in US

ETFs that hold Septerna Inc

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43 thematic and core ETFs hold Septerna Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. XPH holds the most, at 2.22% of the fund on Nov 3, 2026. The next largest are FYC (0.72%) and MMSC (0.69%).

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1 income and other fund on it is listed below.

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Share of each fund · one bar per fund, largest first
XPH 2.22%43 fundsVTHR <0.01%
0
funds above 10%
0.03%
median share
42
funds under 1%

Thematic and core funds that hold it

43 funds
43 of 43 · click a column to sort
ETFs that hold Septerna Inc
#FundNameShare of the fund ↓Holdings filedAsset
1XPHState Street SPDR S&P Pharmaceuticals ETF2.22%Nov 3, 2026Equity
2FYCFirst Trust Small Cap Growth AlphaDEX Fund0.72%Nov 3, 2026Equity
3MMSCFirst Trust Multi-Manager Small Cap Opportunities ETF0.69%Nov 3, 2026Equity
4BBCVirtus Biotech Clinical Trials ETF0.64%Jul 31, 2026Equity
5FYXFirst Trust Small Cap Core AlphaDEX Fund0.34%Nov 3, 2026Equity
6AFSMFirst Trust Active Factor Small Cap ETF0.32%Nov 3, 2026Equity
7IHEiShares U.S. Pharmaceuticals ETF0.22%Nov 3, 2026Equity
8SQLVRoyce Quant Small-Cap Quality Value ETF0.18%Jun 30, 2026Equity
9SYZLazard US Systematic Small Cap Equity ETF0.17%Jun 30, 2026Equity
10FSCCFederated Hermes MDT Small Cap Core ETF0.16%Aug 31, 2026Equity
11ACSGAmerican Century Small Cap Growth Insights ETF0.15%Aug 31, 2026Equity
12FADFirst Trust Multi Cap Growth AlphaDEX Fund0.15%Nov 3, 2026Equity
13JPSEJPMorgan Diversified Return U.S. Small Cap Equity ETF0.15%Nov 3, 2026Equity
14IBBQInvesco Nasdaq Biotechnology ETF0.13%Nov 3, 2026Equity
15VFMOVanguard U.S. Momentum Factor ETF0.10%Sep 30, 2026Equity
16IBBiShares Biotechnology ETF0.09%Nov 3, 2026Equity
17AVSCAvantis U.S. Small Cap Equity ETF0.08%Nov 2, 2026Equity
18RESMColumbia Research Enhanced Small Cap ETF0.04%Jun 30, 2026Equity
19IWOiShares Russell 2000 Growth ETF0.04%Nov 3, 2026Equity
20GSSCGS ActiveBeta U.S. Small Cap Equity ETF0.04%Aug 31, 2026Equity
21VTWGVanguard Russell 2000 Growth ETF0.04%Sep 30, 2026Equity
22ISCGiShares Morningstar Small-Cap Growth ETF0.03%Nov 3, 2026Equity
23IWMiShares Russell 2000 ETF0.03%Nov 3, 2026Equity
24VTWOVanguard Russell 2000 ETF0.03%Sep 30, 2026Equity
25RSSLGlobal X Russell 2000 ETF0.02%Jul 31, 2026Equity
26IWNiShares Russell 2000 Value ETF0.02%Nov 3, 2026Equity
27OMFSInvesco Russell 2000 Dynamic Multifactor ETF0.02%Nov 3, 2026Equity
28PRFZInvesco RAFI US 1500 Small-Mid ETF0.02%Nov 3, 2026Equity
29SCHASchwab U.S. Small-Cap ETF0.02%Aug 31, 2026Equity
30VTWVVanguard Russell 2000 Value ETF0.02%Sep 30, 2026Equity
31ISCB(name not filed)0.01%Jul 31, 2026Equity
32MSMLiShares MSCI USA Small-Cap ETF0.01%Nov 3, 2026Equity
33VXFVanguard Extended Market ETF0.01%Sep 30, 2026Equity
34WSMLiShares MSCI World Small-Cap ETF0.01%Nov 3, 2026Equity
35VHTVanguard Health Care ETF0.01%Sep 30, 2026Equity
36ONEQFidelity Nasdaq Composite Index ETF0.01%Aug 31, 2026Equity
37FHLCFidelity MSCI Health Care Index ETF0.01%Jul 31, 2026Equity
38MSSMMorgan Stanley Pathway Small-Mid Cap Equity ETF<0.01%Aug 31, 2026Equity
39DFASU.S. Small Cap Portfolio: ETF Class Shares<0.01%Jul 31, 2026Equity
40VTIVanguard Morningstar Total Stock Market ETF<0.01%Sep 30, 2026Equity
41DFAUDimensional US Core Equity Market ETF<0.01%Jul 31, 2026Equity
42SCHBSchwab U.S. Broad Market ETF<0.01%Aug 31, 2026Equity
43VTHRVanguard Russell 3000 ETF<0.01%Sep 30, 2026Equity
As of Nov 5, 2026. Source: each fund's own holdings.

Income and other funds that hold it

Income and other funds that hold it
#FundNameShare of the fundHoldings filedCategory
1ITWOProShares Russell 2000 High Income ETF0.02%Aug 31, 2026Income
As of Nov 5, 2026. Source: each fund's own holdings.

How we count

Septerna Inc (ticker SEPN, listed in US) is matched in every holdings book ETFIQ publishes, by its ticker and name.

Amber dates are more than a quarter old; the fund may have traded since.

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Questions people ask

Which ETFs hold Septerna Inc?
43 thematic and core ETFs hold Septerna Inc, by holdings dated Jun 30, 2026 to Nov 3, 2026. The largest positions are XPH at 2.22% of the fund on Nov 3, 2026, FYC at 0.72% of the fund on Nov 3, 2026 and MMSC at 0.69% of the fund on Nov 3, 2026. 1 income and other fund on it is listed apart.
Sources and dates
HoldingsSEC Form N-PORT, what a fund filed it holds ↗
FilingsSEC EDGAR, full-text search of fund filings ↗

Links go to the source documents. ETFIQ is an independent publisher and makes no recommendations. Standards and sources →

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ETFIQ, ETFs holding Septerna Inc, data as of Nov 5, 2026. https://etfiq.com/holdings/sepn/

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