Do BBP and PBE hold the same stocks?

By their latest filings, 30% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, BBP or PBE?

BBP has 10% of its weight in S&P 500 names and PBE has 32%, so BBP differs more from the index.

Which is cheaper, BBP or PBE?

BBP charges 0.34% a year and PBE charges 0.59%, so BBP is cheaper. Fees come from each fund's prospectus.

Data as of Nov 4, 2026.

Thematic ETFs

BBP vs PBE: Holdings Overlap & Returns

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Over the year to Nov 4, 2026, BBP returned +44.4% to PBE's +44.2%; 30% of their weight is in the same names.

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Net assets: $99m on Jul 31, 2026 for Virtus Biotech ETF, and $442m on Nov 3, 2026 for Invesco Biotechnology & Genome ETF.

BBP on its own →PBE on its own →

At a glance

10.5%

BBP in the S&P 500

32.3%

PBE in the S&P 500

+44.4%

BBP total return, 1 year

+44.2%

PBE total return, 1 year

BBP · 1 year to Nov 4, 2026 90% of its weight is outside the S&P 500

11% of BBP's weight is in S&P 500 companies and 90% is outside the index. Holdings as of Jul 31, 2026.

PBE · 1 year to Nov 4, 2026 68% of its weight is outside the S&P 500

32% of PBE's weight is in S&P 500 companies and 68% is outside the index. Holdings as of Nov 3, 2026.

Pair scorecard

BBP costs 0.25 points a year less; their one-year returns differ by 0.2 points.

BBP vs PBE: Holdings Overlap & Returns
Measure	BBP	PBE
Return
Measure	BBP	PBE
Total return, 1 year	+44.4%	+44.2%
Benchmark
Measure	BBP	PBE
What it tracks	Biotech	Biotech
Cost and size
Measure	BBP	PBE
Expense ratio	0.34%	0.59%
Net assets, BBP as of Jul 31, 2026 and PBE as of Nov 3, 2026	$99m	$442m
Holdings
Measure	BBP	PBE
Holdings in common	30%

Method

What they share

30%

By the books each fund has filed, BBP and PBE hold 30% of their money in the same securities at the same weight. Holdings dated Jul 31, 2026 and Nov 3, 2026.

50%

0 half 100%

half

30% in common

Positions both hold · largest shared weight first BBP PBE

REGENERON PHARMACEUTICALS 1.72% 5.62%

PROTAGONIST THERAPEUTICS INC 1.71% 2.45%

ACADIA PHARMACEUTICALS INC 1.69% 1.77%

HALOZYME THERAPEUTICS INC 1.64% 3.09%

INCYTE CORP 1.52% 2.38%

MODERNA INC 1.51% 3.78%

AMGEN INC 1.49% 5.02%

VERTEX PHARMACEUTICALS INC 1.48% 4.62%

BIOMARIN PHARMACEUTICAL INC 1.48% 2.21%

TG THERAPEUTICS INC 1.45% 2.88%

NEUROCRINE BIOSCIENCES INC 1.44% 2.82%

GILEAD SCIENCES INC 1.43% 5.42%

Only in one fund ↓

Only in BBP

CRINETICS PHARMACEUTICALS INC 3.34%

KINIKSA PHARMACEUTICALS INTERNATIONAL PLC 1.97%

VERASTEM INC 1.95%

PRECIGEN INC 1.94%

OMEROS CORP 1.87%

NUVATION BIO INC 1.77%

BRIDGEBIO PHARMA INC 1.65%

BEONE MEDICINES LTD 1.65%

Only in PBE

Natera Inc 5.56%

Royalty Pharma PLC 5.15%

Illumina Inc 5.10%

QIAGEN NV 3.03%

Veracyte Inc 3.00%

Repligen Corp 2.58%

Vericel Corp 2.50%

Collegium Pharmaceutical Inc 2.27%

Check overlap with more funds →

Window by window

Window by window: BBP vs PBE: Holdings Overlap & Returns
	Total return
Window	BBP	PBE
3 months	+8.8%	+14.2%
6 months	+16.6%	+27.1%
1 year	+44.4%	+44.2%
3 years	+113.7%	+90.4%
Since launchNot the same days: BBP Dec 2014 · PBE Jun 2005	+310.5%	+650.5%

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Side by side

BBP Virtus Biotech ETF · Holds 67 stocks in biotech, 10% of its weight in S&P 500 companies PBE Invesco Biotechnology & Genome ETF · Holds 32 stocks in biotech, 32% of its weight in S&P 500 companies

Issuer Virtus Invesco

Theme Biotech Biotech

In the S&P 500 10.5% 32.3%

Active share vs the S&P 500 99.0% 99.0%

In the Nasdaq-100 7.1% 20.7%

Holdings 67 32

Top ten, share of the fund 19.6% 49.1%

Expense ratio 0.34% 0.59%

Fee for the differing part 0.34% 0.60%

Total return, 1 year +44.4% +44.2%

vs its benchmark not measured not measured

Below its high −4.1% 0.0%

Net assets, BBP as of Jul 31, 2026 and PBE as of Nov 3, 2026 $99m $442m

As of Nov 4, 2026. Source: ETFIQ.

30% of the two portfolios are the same securities at the same weight.

Alert

About each fund

BBP

By weight, 10% of BBP's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 20% of the fund across 67 positions, as filed for Jul 31, 2026. Over the year to Nov 4, 2026 the fund returned +44.4% with distributions reinvested.

PBE

By weight, 32% of PBE's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 49% of the fund across 32 positions, as published by its issuer for Nov 3, 2026. Over the year to Nov 4, 2026 the fund returned +44.2% with distributions reinvested.

Questions people ask

Do BBP and PBE hold the same stocks?: By their latest filings, 30% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, BBP or PBE?: BBP has 10% of its weight in S&P 500 names and PBE has 32%, so BBP differs more from the index.
Which is cheaper, BBP or PBE?: BBP charges 0.34% a year and PBE charges 0.59%, so BBP is cheaper. Fees come from each fund's prospectus.

Other comparisons

BBP vs IBBQ BBP vs XBI BBP vs IBB BBP vs BBH PBE vs PBPH PBE vs XBI PBE vs IBBQ PBE vs FBT

Where to next

All thematic ETFs ranked by the S&P 500 Difference Score →How the scores are computed →BBP on its own →PBE on its own →BBP holdings →PBE dividend history →PBE holdings →Method →Standards and sources →

Sources and dates

BBP filings on SEC EDGAR ↗

BBP prospectus with the expense ratio (SEC) ↗

Virtus website ↗

PBE filings on SEC EDGAR ↗

PBE prospectus with the expense ratio (SEC) ↗

Invesco page for PBE ↗

Links are sources, not endorsements. A comparison is not a recommendation.

How this is computed

Overlap adds up the smaller of the two weights for each security both funds hold.

Every number is an ETFIQ calculation with distributions reinvested.

Cite this pageCitation, APA and Markdown

ETFIQ, BBP against PBE, data as of Nov 4, 2026. https://etfiq.com/compare/themes/bbp-vs-pbe

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.