Data as of Oct 28, 2026.
XBI vs XLRE: Differences, Returns & Fees
Over the year to Oct 28, 2026, XBI returned +41.2% to XLRE's +4.3%, and XLRE charges 0.08% to XBI's 0.35%.
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Net assets on Oct 27, 2026: $10.3bn for State Street SPDR S&P Biotech ETF and $8.0bn for State Street Real Estate Select Sector SPDR ETF.
Pair scorecard
XLRE costs 0.27 points a year less; their one-year returns differ by 36.9 points; XBI is 1.3 times larger.
| Measure | XBI | XLRE |
|---|---|---|
| Return | ||
| Total return, 1 year | +41.2% | +4.3% |
| Drawdown | ||
| Below its all-time high | 8.9%, high on Feb 8, 2021 | |
| Below its high | 7.7%, high on Jul 28, 2026 | |
| Benchmark | ||
| What it tracks | Biotech | Real Estate Select Sector Index |
| Cost and size | ||
| Expense ratio | 0.35% | 0.08% |
| Net assets, as of Oct 27, 2026 | $10.3bn | $8.0bn |
| Active share vs the S&P 500 | 98% | |
| Holdings | ||
| Holdings in common | 0% | |
| Top ten holdings, share of the fund | 18% | 58.9% |
Holdings in common uses holdings dated Oct 27, 2026. Method
What they share
By the books each fund has filed, XBI and XLRE hold 0% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.
half
0% in common
Only in one fund ↓
Side by side
XBI and XLRE on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.
XBI
By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 18% of the fund across 165 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +41.2% with distributions reinvested. It sits 8.9% below its all-time high of Feb 8, 2021.
XLRE
XLRE tracks an index of Real estate. Over the year to Oct 28, 2026 it returned +4.3% with distributions reinvested. The prospectus expense ratio is 0.08% a year. By its holdings published by its issuer for Oct 27, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 31 positions, with the top ten at 58.9%. It sat 7.7% below its high of Jul 28, 2026 on Oct 28, 2026.
Questions people ask
- Are XBI and XLRE in the same category?
- XBI is a thematic ETF and XLRE is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
- Which returned more over the last year, XBI or XLRE?
- In the year to Oct 28, 2026, with distributions reinvested, XBI returned +41.2% and XLRE +4.3%.
- Which is cheaper, XBI or XLRE?
- XLRE is cheaper, by 0.27 percentage points a year. That is about $27 on $10,000 held for a year. Fees come from each fund's prospectus.
Links are sources, not endorsements. A comparison is not a recommendation.
How this is computed
Overlap adds up the smaller of the two weights for each security both funds hold.
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ETFIQ, XBI against XLRE, data as of Oct 28, 2026. https://etfiq.com/compare/any/xbi-vs-xlre
ETFIQ. (Oct 28, 2026). XBI against XLRE. Retrieved from https://etfiq.com/compare/any/xbi-vs-xlre
[XBI against XLRE (ETFIQ, Oct 28, 2026)](https://etfiq.com/compare/any/xbi-vs-xlre)
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