Data as of Oct 28, 2026.

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VOOG vs XBI: Differences, Returns & Fees

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Over the year to Oct 28, 2026, VOOG returned +12.1% to XBI's +41.2%, and VOOG charges 0.05% to XBI's 0.35%.

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Net assets: $27.8bn on Sep 30, 2026 for Vanguard S&P 500 Growth ETF, and $10.3bn on Oct 27, 2026 for State Street SPDR S&P Biotech ETF.

At a glance
+12.1%
VOOG total return, 1 year
+41.2%
XBI total return, 1 year
0.05%
VOOG expense ratio
0.35%
XBI expense ratio

Pair scorecard

VOOG costs 0.30 points a year less; their one-year returns differ by 29.1 points; VOOG is 2.7 times larger.

VOOG vs XBI: Differences, Returns & Fees
MeasureVOOGXBI
Return
Total return, 1 year+12.1%+41.2%
Drawdown
Below its high4.1%, high on Oct 6, 2026
Below its all-time high8.9%, high on Feb 8, 2021
Benchmark
What it tracksS&P 500 Growth IndexBiotech
Cost and size
Expense ratio0.05%0.35%
Net assets, as of Sep 30, 2026$27.8bn$10.4bn
Active share vs the S&P 50098%
Holdings
Holdings in common1%
Top ten holdings, share of the fund60.2%18%

Holdings in common uses holdings dated Sep 30, 2026 and Oct 27, 2026. Method

What they share

1%

By the books each fund has filed, VOOG and XBI hold 1% of their money in the same securities at the same weight. Holdings dated Sep 30, 2026 and Oct 27, 2026.

0 half 100%

half

1% in common

Positions both hold · largest shared weight first VOOG XBI
AbbVie Inc 0.58% 1.67%
Amgen Inc 0.42% 1.68%
Gilead Sciences Inc 0.27% 1.60%
Incyte Corp 0.06% 1.35%
Only in one fund ↓
Only in VOOG
NVIDIA Corp 15.01%
Microsoft Corp 10.34%
Apple Inc 6.60%
Alphabet Inc 5.48%
Broadcom Inc 4.54%
Alphabet Inc 4.39%
Meta Platforms Inc 4.34%
Amazon.com Inc 3.52%
Only in XBI
MODERNA INC 2.24%
TWIST BIOSCIENCE CORP 1.86%
NATERA INC 1.82%
BIOGEN INC 1.75%
HALOZYME THERAPEUTICS INC 1.75%
UNITED THERAPEUTICS CORP 1.71%
SPYRE THERAPEUTICS INC 1.67%
EXELIXIS INC 1.64%
Check overlap with more funds →

Side by side

VOOG Vanguard S&P 500 Growth ETF XBI State Street SPDR S&P Biotech ETF
Where it sits Stock ETF Thematic ETF
What it is Tracks the S&P 500 Growth Biotech
Total return, 1 year +12.1% +41.2%
Its benchmark over the same days +12.1% (IVW) not measured
Gap to its benchmark 0.0 pts vs IVW not measured
Expense ratio 0.05% 0.35%
Already in the S&P 500 99.8% 13.2%
Holdings 154 165
Net assets, VOOG as of Sep 30, 2026 and XBI as of Oct 27, 2026 $27.8bn $10.3bn

VOOG and XBI on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
VOOG

VOOG tracks the S&P 500 Growth. Over the year to Oct 28, 2026 it returned +12.1% with distributions reinvested, against +12.1% for its benchmark, the S&P 500 Growth Index. The prospectus expense ratio is 0.05% a year. By its holdings published by its issuer as of Sep 30, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 154 positions, with the top ten at 60.2%. It sat 4.1% below its high of Oct 6, 2026 on Oct 28, 2026.

XBI

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 18% of the fund across 165 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +41.2% with distributions reinvested. It sits 8.9% below its all-time high of Feb 8, 2021.

Questions people ask

Are VOOG and XBI in the same category?
VOOG is a stock ETF and XBI is a thematic ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, VOOG or XBI?
In the year to Oct 28, 2026, with distributions reinvested, VOOG returned +12.1% and XBI +41.2%.
Which is cheaper, VOOG or XBI?
VOOG is cheaper, by 0.30 percentage points a year. That is about $30 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do VOOG and XBI overlap with the S&P 500?
By their latest filed holdings, 100% of VOOG and 13% of XBI by weight is stocks the S&P 500 already holds.
Other comparisons
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ETFIQ, VOOG against XBI, data as of Oct 28, 2026. https://etfiq.com/compare/any/voog-vs-xbi

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