Are ITOT and XBI in the same category?

ITOT is a stock ETF and XBI is a thematic ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.

Which returned more over the last year, ITOT or XBI?

In the year to Oct 28, 2026, with distributions reinvested, ITOT returned +13.4% and XBI +41.2%.

Which is cheaper, ITOT or XBI?

ITOT is cheaper, by 0.32 percentage points a year. That is about $32 on $10,000 held for a year. Fees come from each fund's prospectus.

How much do ITOT and XBI overlap with the S&P 500?

By their latest filed holdings, 88% of ITOT and 13% of XBI by weight is stocks the S&P 500 already holds.

Data as of Oct 28, 2026.

Across categories

ITOT vs XBI: Differences, Returns & Fees

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Over the year to Oct 28, 2026, ITOT returned +13.4% to XBI's +41.2%, and ITOT charges 0.03% to XBI's 0.35%.

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Net assets on Oct 27, 2026: $97.1bn for iShares Core S&P Total U.S. Stock Market ETF and $10.3bn for State Street SPDR S&P Biotech ETF.

ITOT on its own →XBI on its own →

At a glance

+13.4%

ITOT total return, 1 year

+41.2%

XBI total return, 1 year

0.03%

ITOT expense ratio

0.35%

XBI expense ratio

Pair scorecard

ITOT costs 0.32 points a year less; their one-year returns differ by 27.8 points; ITOT is 9.4 times larger.

ITOT vs XBI: Differences, Returns & Fees
Measure	ITOT	XBI
Return
Measure	ITOT	XBI
Total return, 1 year	+13.4%	+41.2%
Drawdown
Measure	ITOT	XBI
Below its all-time high		8.9%, high on Feb 8, 2021
Benchmark
Measure	ITOT	XBI
What it tracks	S&P Total Market Index (TMI)	Biotech
Cost and size
Measure	ITOT	XBI
Expense ratio	0.03%	0.35%
Net assets, as of Oct 27, 2026	$97.1bn	$10.3bn
Active share vs the S&P 500		98%
Holdings
Measure	ITOT	XBI
Holdings in common	2%
Top ten holdings, share of the fund	33.9%	18%

Holdings in common uses holdings dated Oct 27, 2026. Method

What they share

By the books each fund has filed, ITOT and XBI hold 2% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

50%

0 half 100%

half

2% in common

Positions both hold · largest shared weight first ITOT XBI

ABBVIE 0.68% 1.67%

AMGEN INC 0.32% 1.68%

GILEAD SCIENCES 0.26% 1.60%

VERTEX PHARMACEUTICALS 0.18% 1.46%

REGENERON PHARMACEUTICALS 0.11% 1.48%

MODERNA 0.10% 2.24%

NATERA 0.08% 1.82%

BIOGEN 0.05% 1.75%

REVOLUTION MEDICINES 0.05% 1.31%

ALNYLAM PHARMACEUTICALS 0.04% 1.29%

INCYTE CORP 0.03% 1.35%

INSMED 0.03% 1.08%

Only in one fund ↓

Only in ITOT

NVIDIA 7.06%

APPLE 6.78%

MICROSOFT 5.28%

AMAZON.COM INC 3.32%

ALPHABET CLASS A 2.52%

BROADCOM INC 2.18%

ALPHABET CLASS C 2.02%

META PLATFORMS CLASS A 1.83%

Only in XBI

EDITAS MEDICINE INC 0.11%

SHATTUCK LABS INC 0.10%

CLIMB BIO INC 0.10%

DESIGN THERAPEUTICS INC 0.10%

CONTRA METSERA INC 0.07%

NEUROGENE INC 0.07%

ASSEMBLY BIOSCIENCES INC 0.06%

CRESCENT BIOPHARMA INC 0.04%

Check overlap with more funds →

Side by side

ITOT iShares Core S&P Total U.S. Stock Market ETF XBI State Street SPDR S&P Biotech ETF

Where it sits Stock ETF Thematic ETF

Issuer iShares State Street

What it is Tracks the S&P Total U.S. Stock Market Biotech

Total return, 1 year +13.4% +41.2%

Expense ratio 0.03% 0.35%

Already in the S&P 500 88.1% 13.2%

Holdings 2443 165

Net assets, as of Oct 27, 2026 $97.1bn $10.3bn

ITOT and XBI on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

Alert

About each fund

ITOT

ITOT tracks the S&P Total U.S. Stock Market. Over the year to Oct 28, 2026 it returned +13.4% with distributions reinvested. The prospectus expense ratio is 0.03% a year. By its holdings published by its issuer for Oct 27, 2026, 88% of the fund by weight is stocks the S&P 500 also holds, across 2,443 positions, with the top ten at 33.9%.

XBI

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 18% of the fund across 165 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +41.2% with distributions reinvested. It sits 8.9% below its all-time high of Feb 8, 2021.

Questions people ask

Are ITOT and XBI in the same category?: ITOT is a stock ETF and XBI is a thematic ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, ITOT or XBI?: In the year to Oct 28, 2026, with distributions reinvested, ITOT returned +13.4% and XBI +41.2%.
Which is cheaper, ITOT or XBI?: ITOT is cheaper, by 0.32 percentage points a year. That is about $32 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do ITOT and XBI overlap with the S&P 500?: By their latest filed holdings, 88% of ITOT and 13% of XBI by weight is stocks the S&P 500 already holds.

Other comparisons

IBB vs ITOT ITOT vs REMX ITOT vs LYTE AIRR vs ITOT SPYM vs XBI CGGR vs XBI USMV vs XBI XBI vs XLG

Where to next

ITOT on its own →XBI on its own →Hold both: look the portfolio through →Rankings →ITOT dividend history →ITOT holdings →XBI dividend history →XBI holdings →Standards and sources →

Sources and dates

ITOT filings on SEC EDGAR ↗

ITOT prospectus with the expense ratio (SEC) ↗

iShares page for ITOT ↗

XBI filings on SEC EDGAR ↗

XBI prospectus with the expense ratio (SEC) ↗

State Street website ↗

Links are sources, not endorsements. A comparison is not a recommendation.

How this is computed

Overlap adds up the smaller of the two weights for each security both funds hold.

Cite this pageCitation, APA and Markdown

ETFIQ, ITOT against XBI, data as of Oct 28, 2026. https://etfiq.com/compare/any/itot-vs-xbi

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.