Data as of Sep 13, 2026. Both funds on the fields they both publish, from the same sources.
IBB vs ITOT: how they differ
IBB and ITOT hold 2% of their weight in the same names, and IBB returned more over the year.
iShares Biotechnology ETF and iShares Core S&P Total U.S. Stock Market ETF.
What they hold in common
By the books each fund has filed, IBB and ITOT hold 2% of their money in the same securities at the same weight.
| Holding | IBB | ITOT |
|---|---|---|
| AMGEN INC | 7.85% | 0.28% |
| GILEAD SCIENCES | 7.44% | 0.24% |
| VERTEX PHARMACEUTICALS | 7.94% | 0.18% |
| REGENERON PHARMACEUTICALS | 5.92% | 0.11% |
| BLK CSH FND TREASURY SL AGENCY | 0.12% | 0.07% |
| MODERNA | 3.67% | 0.07% |
| NATERA | 3.30% | 0.06% |
| REVOLUTION MEDICINES | 2.87% | 0.06% |
| USD CASH | 0.05% | 0.09% |
| ALNYLAM PHARMACEUTICALS | 2.44% | 0.04% |
| BIOGEN | 2.33% | 0.04% |
| ILLUMINA INC | 2.25% | 0.04% |
| Only in IBB | Only in ITOT |
|---|---|
| ARGENX SE ADR 3.78% | NVIDIA 7.32% |
| BEONE MEDICINES AG 2.01% | APPLE 6.63% |
| GENMAB SPONSORED ADR 1.25% | MICROSOFT 5.06% |
| ASCENDIS PHARMA 1.20% | AMAZON.COM INC 3.41% |
| BIONTECH SE ADR 0.65% | ALPHABET CLASS A 2.70% |
| ABIVAX AMERICAN DEPOSITARY SHARES 0.55% | BROADCOM INC 2.37% |
| XENON PHARMACEUTICALS 0.40% | ALPHABET CLASS C 2.16% |
| ACADIA PHARMACEUTICALS 0.35% | META PLATFORMS CLASS A 1.96% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 10, 2026.
| IBB iShares Biotechnology ETF | ITOT iShares Core S&P Total U.S. Stock Market ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | iShares |
| What it is | Biotechnology | Core S&P Total U.S. Stock Market |
| Total return, 1 year | +41.5% | +17.2% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +24.0 pts | −0.3 pts |
| Expense ratio | 0.44% | 0.03% |
| Already in the S&P 500 | 35.6% | 88.3% |
| Holdings | 233 | 1167 |
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Sep 10, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 233 positions, with the top ten at 47.5%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
ITOT in plain words
ITOT is an index equity fund tracking the Core S&P Total U.S. Stock Market. Over the year to Sep 11, 2026 it returned +17.2% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.03% a year. By its holdings filed for Sep 10, 2026, 88% of the fund by weight is stocks the S&P 500 also holds, across 1167 positions, with the top ten at 34.6%.
Questions people ask
- Which returned more over the last year, IBB or ITOT?
- In the year to Sep 13, 2026, with distributions reinvested, IBB returned +41.5% and ITOT returned +17.2%, so IBB returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, IBB or ITOT?
- IBB charges 0.44% a year and ITOT charges 0.03%, so ITOT is cheaper. Fees come from each fund's prospectus.
- How much do IBB and ITOT overlap with the S&P 500?
- By their latest filed holdings, 36% of IBB and 88% of ITOT by weight is stocks the S&P 500 already holds. Between the two funds, 2% of their books are the same securities at the same weight.
Other comparisons
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IBB against ITOT, data as of Sep 13, 2026. https://etfiq.com/compare/any/ibb-vs-itot Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources