Are IBB and ITOT in the same category?

IBB is a thematic ETF and ITOT is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.

Which returned more over the last year, IBB or ITOT?

In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and ITOT +13.4%.

Which is cheaper, IBB or ITOT?

ITOT is cheaper, by 0.41 percentage points a year. That is about $41 on $10,000 held for a year. Fees come from each fund's prospectus.

How much do IBB and ITOT overlap with the S&P 500?

By their latest filed holdings, 40% of IBB and 88% of ITOT by weight is stocks the S&P 500 already holds.

Data as of Oct 28, 2026.

Across categories

IBB vs ITOT: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to ITOT's +13.4%, and ITOT charges 0.03% to IBB's 0.44%.

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Net assets on Oct 27, 2026: $11.0bn for iShares Biotechnology ETF and $97.1bn for iShares Core S&P Total U.S. Stock Market ETF.

IBB on its own →ITOT on its own →

At a glance

+37.5%

IBB total return, 1 year

+13.4%

ITOT total return, 1 year

0.44%

IBB expense ratio

0.03%

ITOT expense ratio

Pair scorecard

ITOT costs 0.41 points a year less; their one-year returns differ by 24.1 points; ITOT is 8.8 times larger.

IBB vs ITOT: Differences, Returns & Fees
Measure	IBB	ITOT
Return
Measure	IBB	ITOT
Total return, 1 year	+37.5%	+13.4%
Benchmark
Measure	IBB	ITOT
What it tracks	Biotech	S&P Total Market Index (TMI)
Cost and size
Measure	IBB	ITOT
Expense ratio	0.44%	0.03%
Net assets, as of Oct 27, 2026	$11.0bn	$97.1bn
Active share vs the S&P 500	99%
Holdings
Measure	IBB	ITOT
Holdings in common	2%
Top ten holdings, share of the fund	50%	33.9%

Holdings in common uses holdings dated Oct 27, 2026. Method

What they share

By the books each fund has filed, IBB and ITOT hold 2% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

50%

0 half 100%

half

2% in common

Positions both hold · largest shared weight first IBB ITOT

AMGEN INC 8.20% 0.32%

GILEAD SCIENCES 8.56% 0.26%

VERTEX PHARMACEUTICALS 7.53% 0.18%

REGENERON PHARMACEUTICALS 5.64% 0.11%

MODERNA 5.29% 0.10%

NATERA 3.85% 0.08%

ILLUMINA INC 2.93% 0.06%

BIOGEN 2.58% 0.05%

REVOLUTION MEDICINES 2.50% 0.05%

ALNYLAM PHARMACEUTICALS 2.11% 0.04%

INCYTE CORP 1.63% 0.03%

INSMED 1.42% 0.03%

Only in one fund ↓

Only in IBB

ARGENX SE ADR 3.42%

BEONE MEDICINES AG 2.15%

GENMAB SPONSORED ADR 1.72%

ASCENDIS PHARMA 1.06%

BIONTECH SE ADR 0.58%

ABIVAX AMERICAN DEPOSITARY SHARES 0.44%

LEGEND BIOTECH ADR REP 0.25%

XENON PHARMACEUTICALS 0.23%

Only in ITOT

NVIDIA 7.06%

APPLE 6.78%

MICROSOFT 5.28%

AMAZON.COM INC 3.32%

ALPHABET CLASS A 2.52%

BROADCOM INC 2.18%

ALPHABET CLASS C 2.02%

META PLATFORMS CLASS A 1.83%

Check overlap with more funds →

Side by side

IBB iShares Biotechnology ETF ITOT iShares Core S&P Total U.S. Stock Market ETF

Where it sits Thematic ETF Stock ETF

Issuer iShares iShares

What it is Biotech Tracks the S&P Total U.S. Stock Market

Total return, 1 year +37.5% +13.4%

Expense ratio 0.44% 0.03%

Already in the S&P 500 40.2% 88.1%

Holdings 245 2443

Net assets, as of Oct 27, 2026 $11.0bn $97.1bn

IBB and ITOT on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

Alert

About each fund

IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

ITOT

ITOT tracks the S&P Total U.S. Stock Market. Over the year to Oct 28, 2026 it returned +13.4% with distributions reinvested. The prospectus expense ratio is 0.03% a year. By its holdings published by its issuer for Oct 27, 2026, 88% of the fund by weight is stocks the S&P 500 also holds, across 2,443 positions, with the top ten at 33.9%.

Questions people ask

Are IBB and ITOT in the same category?: IBB is a thematic ETF and ITOT is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or ITOT?: In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and ITOT +13.4%.
Which is cheaper, IBB or ITOT?: ITOT is cheaper, by 0.41 percentage points a year. That is about $41 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do IBB and ITOT overlap with the S&P 500?: By their latest filed holdings, 40% of IBB and 88% of ITOT by weight is stocks the S&P 500 already holds.

Other comparisons

IBB vs SCHX IBB vs SPYM IBB vs IWB IBB vs QUAL ITOT vs XBI GDX vs ITOT ITOT vs LYTE AIRR vs ITOT

Where to next

IBB on its own →ITOT on its own →Hold both: look the portfolio through →Rankings →IBB dividend history →IBB holdings →ITOT dividend history →ITOT holdings →Standards and sources →

Sources and dates

IBB and ITOT filings on SEC EDGAR ↗

IBB and ITOT prospectus with the expense ratio (SEC) ↗

iShares page for IBB ↗

iShares page for ITOT ↗

Links are sources, not endorsements. A comparison is not a recommendation.

How this is computed

Overlap adds up the smaller of the two weights for each security both funds hold.

Cite this pageCitation, APA and Markdown

ETFIQ, IBB against ITOT, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-itot

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.