The largest therapeutics and medical devices ETFs
See 5 funds ranked by net assets. Updated Oct 20, 2026. Every fund here is sold on therapeutics and medical devices. What each one holds, and how much of it the S&P 500 already holds for you, is the column beside the size.
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| # | Ticker | Fund | Net assets ↓ | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
|---|---|---|---|---|---|---|---|
| 1 | IHI | iShares U.S. Medical Devices ETF | $3.5bn, off scale | 88.5% | −10.1% | 0.37% | Issuer daily, Oct 20, 2026 |
| 2 | CANC | Tema Oncology ETF | $204m | 21.9% | +36.5% | 0.75% | Issuer page, Oct 19, 2026 |
| 3 | PSIL | AdvisorShares Psychedelics ETF | $46m | 7.8% | +7.0% | 1.00% | Issuer page, Oct 20, 2026 |
| 4 | IBRN | iShares Neuroscience and Healthcare ETF | $6m | 5.3% | +9.3% | 0.47% | Issuer daily, Oct 20, 2026 |
| 5 | MDEV | First Trust Indxx Medical Devices ETF | $3m | 47.4% | +4.4% | 0.70% | Issuer page, Oct 20, 2026 |
Method
The 5 ETFs in the therapeutics and medical devices theme, of which 5 publish net assets, ranked on the most recent figure for each.
The rest of the method
Across the funds listed here the weight held in S&P 500 companies runs from 5.3% to 88.5%. Size shows where the money is, not what a fund did. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
ETFIQ links to the documents behind every figure; a link is not an endorsement. A ranking is not a recommendation or an opinion.
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ETFIQ, The largest therapeutics and medical devices ETFs, ranked by net assets, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-largest-therapeutics
ETFIQ. (Oct 20, 2026). The largest therapeutics and medical devices ETFs, ranked by net assets. Retrieved from https://etfiq.com/rankings/themes-largest-therapeutics
[The largest therapeutics and medical devices ETFs, ranked by net assets (ETFIQ, Oct 20, 2026)](https://etfiq.com/rankings/themes-largest-therapeutics)
Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.