Themes · ranked by total return with distributions reinvested, one year

The therapeutics ETFs that returned most

See 5 funds ranked by total return with distributions reinvested, one year. Updated Oct 20, 2026. Funds on one theme can hold different companies, so the gap from top to bottom of this list reflects what they own, not the theme.

Ask IQ about this page

Ask IQ about the therapeutics ETFs that returned most

Answers cite the figures on this page.

Share on X Download as PDF

Download CSV

The therapeutics ETFs that returned most
#	Ticker	Fund	Total return, 1Y ↓	vs its benchmark 1Y	Weight in S&P 500 companies	Fee
1	CANC	Tema Oncology ETF	+36.5%	not measured	21.9%	0.75%
2	IBRN	iShares Neuroscience and Healthcare ETF	+9.3%	not measured	5.3%	0.47%
3	PSIL	AdvisorShares Psychedelics ETF	+7.0%	not measured	7.8%	1.00%
4	MDEV	First Trust Indxx Medical Devices ETF	+4.4%	not measured	47.4%	0.70%
5	IHI	iShares U.S. Medical Devices ETF	−10.1%	not measured	88.5%	0.37%

As of Oct 20, 2026. Source: ETFIQ.

Method

The 5 of 5 ETFs in the therapeutics and medical devices theme with a full year of trading, highest first, each over the same year to Oct 20, 2026 with distributions reinvested. Across the funds listed here the one year total return runs from -10.1% to 36.5%.

The rest of the method

A year says what happened, not what happens next. The list sorts one published figure, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.

How these figures are computed →Standards and sources →

Where to next

Every therapeutics and medical devices ETF and what it holds→The largest therapeutics and medical devices ETFs5 →

Where these figures came from

Fund holdings from SEC Form N-PORT and from the issuers own daily files ↗SEC EDGAR, full-text search of fund filings ↗SEC Form N-PORT, what a fund filed it holds ↗Rule 19a-1, what a distribution notice must say ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A ranking is not a recommendation or an opinion.

Cite this pageCitation, APA and Markdown

ETFIQ, The therapeutics ETFs that returned most, ranked by total return with distributions reinvested, data as of Oct 20, 2026. https://etfiq.com/rankings/themes-best-year-therapeutics

Open data →

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms. The underlying files are at Open data.