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IBRN vs PSIL: which is really different?

IBRN and PSIL hold 13% of their weight in the same names, and PSIL returned +30.0% over the year. iShares Neuroscience and Healthcare ETF and AdvisorShares Psychedelics ETF.

4.7%
IBRN in the S&P 500
8.1%
PSIL in the S&P 500
+25.4%
IBRN total return, 1 year
+30.0%
PSIL total return, 1 year
IBRN · 1 year to Sep 30, 202695% of its weight is outside the S&P 500
95% of its weight is outside the S&P 5005% of IBRN's weight is in S&P 500 companies and 95% is outside the index5%95%inof its weight outside the S&P 500active share 100% · top ten 41% of the fund · 80 holdings filed Sep 30, 2026 · Nasdaq-100: 0% in95% of its weight is outside the S&P 5005% of IBRN's weight is in S&P 500 companies and 95% is outside the index5%95%5% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 41% of the fund

5% of IBRN's weight is in S&P 500 companies and 95% is outside the index

PSIL · 1 year to Sep 30, 202692% of its weight is outside the S&P 500
92% of its weight is outside the S&P 5008% of PSIL's weight is in S&P 500 companies and 92% is outside the index8%92%inof its weight outside the S&P 500active share 98% · top ten 72% of the fund · 27 holdings filed Jun 30, 2026 · Nasdaq-100: 0% in92% of its weight is outside the S&P 5008% of PSIL's weight is in S&P 500 companies and 92% is outside the index8%92%8% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 98% · top ten 72% of the fund

8% of PSIL's weight is in S&P 500 companies and 92% is outside the index

ETFIQ Off-Index Score · IBRN scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, IBRN and PSIL hold 13% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and Sep 30, 2026.

half

13% in common

Positions both hold, largest shared weight first
Holding IBRN PSIL
NEUROCRINE BIOSCIENCES 4.22% 4.57%
ALKERMES 4.07% 4.48%
SUPERNUS PHARMACEUTICALS 3.43% 3.01%
ALTO NEUROSCIENCE INC 1.32% 4.38%
BRIGHT MINDS BIOSCIENCES 0.55% 4.00%
Only in IBRN
BIOGEN 4.74%
EDGEWISE THERAPEUTICS 4.36%
PTC THERAPEUTICS 4.33%
ARGENX SE ADR 4.31%
SCHOLAR ROCK HOLDING 4.04%
PRAXIS PRECISION MEDICINES 3.83%
DIANTHUS THERAPEUTICS INC 3.77%
ACADIA PHARMACEUTICALS 3.33%
Only in PSIL
DEFINIUM THERAPEUTICS INC 13.40%
COMPASS PATHWAYS PLC 11.94%
ATAIBECKLEY INC 10.92%
RELMADA THERAPEUTICS INC 7.13%
NRX PHARMACEUTICALS INC 6.32%
CYBIN INC 4.54%
GH RESEARCH PLC 4.50%
ABBVIE INC 4.32%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

13% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowIBRNPSILIBRNPSILIBRNPSIL
3 months−13.2%−1.1%−15.7 pts−3.6 pts−15.3 pts−3.2 pts
6 months−0.1%+29.4%−17.1 pts+12.4 pts−26.9 pts+2.5 pts
1 year+25.4%+30.0%+9.7 pts+14.3 pts+1.6 pts+6.2 pts
3 years+60.7%+58.6%−24.3 pts−26.4 pts−49.3 pts−51.4 pts
Since launch
IBRN Aug 2022 · PSIL Sep 2021
+37.4%−73.9%−61.7 pts−156.8 pts−109.4 pts−175.5 pts

IBRN and PSIL over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

IBRN
iShares Neuroscience and Healthcare ETF · Holds 80 stocks in therapeutics and medical devices, 5% of its weight in S&P 500 companies
PSIL
AdvisorShares Psychedelics ETF · Holds 27 stocks in therapeutics and medical devices, 8% of its weight in S&P 500 companies
Issuer iShares AdvisorShares
Theme Therapeutics and medical devices Therapeutics and medical devices
In the S&P 500 4.7% 8.1%
Active share vs the S&P 500 100.0% 98.4%
In the Nasdaq-100 0.0% 0.0%
Holdings 80 27
Top ten, share of the fund 41.1% 72.2%
Expense ratio 0.47% 1.00%
Fee for the differing part 0.47% 1.02%
Total return, 1 year +25.4% +30.0%
vs the S&P 500 +9.7 pts +14.3 pts
vs the Nasdaq-100 +1.6 pts +6.2 pts
Below its high −18.2% −74.6%
Net assets $7m $52m

IBRN and PSIL on the same fields, as of Sep 30, 2026. Source: ETFIQ.

IBRN in plain words

By weight, 5% of IBRN's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 41% of the fund across 80 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +25.4% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 9.7 pts. It sits 18.2% below its all-time high of Aug 19, 2026.

PSIL in plain words

By weight, 8% of PSIL's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 72% of the fund across 27 positions, as filed for Jun 30, 2026. Over the year to Sep 30, 2026 the fund returned +30.0% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 14.3 pts. It sits 74.6% below its all-time high of Sep 22, 2021.

Questions people ask

Do IBRN and PSIL hold the same stocks?
By their latest filings, 13% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, IBRN or PSIL?
IBRN has 5% of its weight in S&P 500 names and PSIL has 8%, so IBRN differs more from the index.
Which is cheaper, IBRN or PSIL?
IBRN charges 0.47% a year and PSIL charges 1.00%, so IBRN is cheaper. Fees come from each fund's prospectus.
Other comparisons
IBRN vs IHIIBRN vs MDEVIBRN vs CANCPSIL vs CANCPSIL vs IHIPSIL vs MDEV
IBRN on its own →PSIL on its own →How every figure is computed →Standards and sources →
Where these figures came from
IBRN filings on SEC EDGAR ↗IBRN prospectus with the expense ratio (SEC) ↗iShares page for IBRN ↗PSIL filings on SEC EDGAR ↗PSIL prospectus with the expense ratio (SEC) ↗AdvisorShares page for PSIL ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, IBRN against PSIL, data as of Sep 30, 2026. https://etfiq.com/compare/themes/ibrn-vs-psil

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.