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IBRN vs MDEV: which is really different?

IBRN and MDEV hold 0% of their weight in the same names, and IBRN returned +25.4% over the year. iShares Neuroscience and Healthcare ETF and First Trust Indxx Medical Devices ETF.

4.7%
IBRN in the S&P 500
47.3%
MDEV in the S&P 500
+25.4%
IBRN total return, 1 year
+4.1%
MDEV total return, 1 year
IBRN · 1 year to Sep 30, 202695% of its weight is outside the S&P 500
95% of its weight is outside the S&P 5005% of IBRN's weight is in S&P 500 companies and 95% is outside the index5%95%inof its weight outside the S&P 500active share 100% · top ten 41% of the fund · 80 holdings filed Sep 30, 2026 · Nasdaq-100: 0% in95% of its weight is outside the S&P 5005% of IBRN's weight is in S&P 500 companies and 95% is outside the index5%95%5% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 41% of the fund

5% of IBRN's weight is in S&P 500 companies and 95% is outside the index

MDEV · 1 year to Sep 30, 202653% of its weight is outside the S&P 500
53% of its weight is outside the S&P 50047% of MDEV's weight is in S&P 500 companies and 53% is outside the index47%53%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 98% · top ten 28% of the fund · 54 holdings filed Sep 30, 2026 · Nasdaq-100: 6% in53% of its weight is outside the S&P 50047% of MDEV's weight is in S&P 500 companies and 53% is outside the index47%53%in the S&P 500outside the S&P 500active share 98% · top ten 28% of the fund

47% of MDEV's weight is in S&P 500 companies and 53% is outside the index

ETFIQ Off-Index Score · IBRN scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, IBRN and MDEV hold 0% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 30, 2026.

half

0% in common

Positions both hold, largest shared weight first
Holding IBRN MDEV
Only in IBRN
BIOGEN 4.74%
EDGEWISE THERAPEUTICS 4.36%
PTC THERAPEUTICS 4.33%
ARGENX SE ADR 4.31%
NEUROCRINE BIOSCIENCES 4.22%
ALKERMES 4.07%
SCHOLAR ROCK HOLDING 4.04%
PRAXIS PRECISION MEDICINES 3.83%
Only in MDEV
Revvity, Inc. 3.21%
WuXi AppTec Co., Ltd. (Class H) 3.13%
Demant A/S 2.84%
Agilent Technologies, Inc. 2.82%
West Pharmaceutical Services, Inc. 2.71%
Baxter International Inc. 2.64%
Waters Corporation 2.58%
Sysmex Corporation 2.56%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

0% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowIBRNMDEVIBRNMDEVIBRNMDEV
3 months−13.2%+7.3%−15.7 pts+4.8 pts−15.3 pts+5.2 pts
6 months−0.1%+8.8%−17.1 pts−8.2 pts−26.9 pts−18.1 pts
1 year+25.4%+4.1%+9.7 pts−11.6 pts+1.6 pts−19.7 pts
3 years+60.7%+15.2%−24.3 pts−69.8 pts−49.3 pts−94.8 pts
Since launch
IBRN Aug 2022 · MDEV Jun 2021
+37.4%−17.7%−61.7 pts−111.3 pts−109.4 pts−137.1 pts

IBRN and MDEV over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

IBRN
iShares Neuroscience and Healthcare ETF · Holds 80 stocks in therapeutics and medical devices, 5% of its weight in S&P 500 companies
MDEV
First Trust Indxx Medical Devices ETF · Holds 54 stocks in therapeutics and medical devices, 47% of its weight in S&P 500 companies
Issuer iShares First Trust
Theme Therapeutics and medical devices Therapeutics and medical devices
In the S&P 500 4.7% 47.3%
Active share vs the S&P 500 100.0% 98.0%
In the Nasdaq-100 0.0% 5.9%
Holdings 80 54
Top ten, share of the fund 41.1% 27.6%
Expense ratio 0.47% 0.70%
Fee for the differing part 0.47% 0.71%
Total return, 1 year +25.4% +4.1%
vs the S&P 500 +9.7 pts −11.6 pts
vs the Nasdaq-100 +1.6 pts −19.7 pts
Below its high −18.2% −25.9%
Net assets $7m $3m

IBRN and MDEV on the same fields, as of Sep 30, 2026. Source: ETFIQ.

IBRN in plain words

By weight, 5% of IBRN's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 41% of the fund across 80 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +25.4% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 9.7 pts. It sits 18.2% below its all-time high of Aug 19, 2026.

MDEV in plain words

By weight, 47% of MDEV's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 28% of the fund across 54 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +4.1% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 11.6 pts. It sits 25.9% below its all-time high of Sep 7, 2021.

Questions people ask

Do IBRN and MDEV hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, IBRN or MDEV?
IBRN has 5% of its weight in S&P 500 names and MDEV has 47%, so IBRN differs more from the index.
Which is cheaper, IBRN or MDEV?
IBRN charges 0.47% a year and MDEV charges 0.70%, so IBRN is cheaper. Fees come from each fund's prospectus.
Other comparisons
IBRN vs IHIIBRN vs PSILIBRN vs CANCMDEV vs PSILMDEV vs CANCMDEV vs IHI
IBRN on its own →MDEV on its own →How every figure is computed →Standards and sources →
Where these figures came from
IBRN filings on SEC EDGAR ↗IBRN prospectus with the expense ratio (SEC) ↗iShares page for IBRN ↗MDEV filings on SEC EDGAR ↗MDEV prospectus with the expense ratio (SEC) ↗First Trust page for MDEV ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, IBRN against MDEV, data as of Sep 30, 2026. https://etfiq.com/compare/themes/ibrn-vs-mdev

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.