Data as of Oct 28, 2026.

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IBB vs TLT: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to TLT's −7.9%, and TLT charges 0.15% to IBB's 0.44%.

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Net assets on Oct 27, 2026: $11.0bn for iShares Biotechnology ETF and $47.4bn for iShares 20+ Year Treasury Bond ETF.

At a glance
+37.5%
IBB total return, 1 year
−7.9%
TLT total return, 1 year
0.44%
IBB expense ratio
0.15%
TLT expense ratio

Pair scorecard

TLT costs 0.29 points a year less; their one-year returns differ by 45.4 points; TLT is 4.3 times larger.

IBB vs TLT: Differences, Returns & Fees
MeasureIBBTLT
Return
Total return, 1 year+37.5%−7.9%
Drawdown
Below its high42.6%, high on Aug 4, 2020
Benchmark
What it tracksBiotechICE U.S. Treasury 20+ Year Bond Index
Cost and size
Expense ratio0.44%0.15%
Net assets, as of Oct 27, 2026$11.0bn$47.4bn
Active share vs the S&P 50099%
Holdings
Holdings in common0%
In the S&P 500, by weight40%
Top ten holdings, share of the fund50%

Holdings in common uses holdings dated Oct 27, 2026. Method

What they share

0%

By the books each fund has filed, IBB and TLT hold 0% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

0% in common

Positions both hold · largest shared weight first IBB TLT
Only in one fund ↓
Only in IBB
GILEAD SCIENCES 8.56%
AMGEN INC 8.20%
VERTEX PHARMACEUTICALS 7.53%
REGENERON PHARMACEUTICALS 5.64%
MODERNA 5.29%
NATERA 3.85%
ARGENX SE ADR 3.42%
ILLUMINA INC 2.93%
Only in TLT
TREASURY BOND 4.32%
TREASURY BOND 4.12%
TREASURY BOND (OLD) 4.07%
TREASURY BOND 4.02%
TREASURY BOND 3.93%
TREASURY BOND 3.92%
TREASURY BOND 3.89%
TREASURY BOND 3.88%
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Side by side

IBB iShares Biotechnology ETF TLT iShares 20+ Year Treasury Bond ETF
Where it sits Thematic ETF Bond ETF
What it is Biotech Tracks an index of 20+ year Treasuries
Total return, 1 year +37.5% −7.9%
Its benchmark over the same days not measured −7.8% (BBLB)
Gap to its benchmark not measured −0.1 pts vs BBLB
Expense ratio 0.44% 0.15%
Holdings 245 47
Net assets, as of Oct 27, 2026 $11.0bn $47.4bn

IBB and TLT on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

TLT

TLT tracks an index of 20+ year Treasuries. Over the year to Oct 28, 2026 it returned −7.9% with distributions reinvested, against −7.8% for its benchmark, the ICE U.S. Treasury 20+ Year Bond Index. The prospectus expense ratio is 0.15% a year. It sat 42.6% below its high of Aug 4, 2020 on Oct 28, 2026.

Questions people ask

Are IBB and TLT in the same category?
IBB is a thematic ETF and TLT is a bond ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or TLT?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and TLT −7.9%.
Which is cheaper, IBB or TLT?
TLT is cheaper, by 0.29 percentage points a year. That is about $29 on $10,000 held for a year. Fees come from each fund's prospectus.
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ETFIQ, IBB against TLT, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-tlt

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