Data as of Oct 28, 2026.

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Across categories

IBB vs VGLT: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to VGLT's −6.7%, and VGLT charges 0.03% to IBB's 0.44%.

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Net assets: $11.0bn on Oct 27, 2026 for iShares Biotechnology ETF, and $10.4bn on Sep 30, 2026 for Vanguard Long-Term Treasury ETF.

At a glance
+37.5%
IBB total return, 1 year
−6.7%
VGLT total return, 1 year
0.44%
IBB expense ratio
0.03%
VGLT expense ratio

Pair scorecard

VGLT costs 0.41 points a year less; their one-year returns differ by 44.2 points; IBB is 1.1 times larger.

IBB vs VGLT: Differences, Returns & Fees
MeasureIBBVGLT
Return
Total return, 1 year+37.5%−6.7%
Drawdown
Below its high38.8%, high on Aug 4, 2020
Benchmark
What it tracksBiotechBloomberg U.S. Long Treasury Index
Cost and size
Expense ratio0.44%0.03%
Net assets, as of Sep 30, 2026$11.2bn$10.4bn
Active share vs the S&P 50099%
Holdings
Holdings in common0%
In the S&P 500, by weight40%
Top ten holdings, share of the fund50%

Holdings in common uses holdings dated Sep 30, 2026 and Oct 27, 2026. Method

What they share

0%

By the books each fund has filed, IBB and VGLT hold 0% of their money in the same securities at the same weight. Holdings dated Sep 30, 2026 and Oct 27, 2026.

0 half 100%

half

0% in common

Positions both hold · largest shared weight first IBB VGLT
Only in one fund ↓
Only in IBB
GILEAD SCIENCES 8.56%
AMGEN INC 8.20%
VERTEX PHARMACEUTICALS 7.53%
REGENERON PHARMACEUTICALS 5.64%
MODERNA 5.29%
NATERA 3.85%
ARGENX SE ADR 3.42%
ILLUMINA INC 2.93%
Only in VGLT
United States Treasury Note/Bond 2.19%
United States Treasury Note/Bond 2.13%
United States Treasury Note/Bond 2.13%
United States Treasury Note/Bond 2.10%
United States Treasury Note/Bond 2.08%
United States Treasury Note/Bond 2.08%
United States Treasury Note/Bond 2.07%
United States Treasury Note/Bond 2.05%
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Side by side

IBB iShares Biotechnology ETF VGLT Vanguard Long-Term Treasury ETF
Where it sits Thematic ETF Bond ETF
What it is Biotech Tracks an index of Long-term Treasury
Total return, 1 year +37.5% −6.7%
Its benchmark over the same days not measured −6.7% (SCHQ)
Gap to its benchmark not measured 0.0 pts vs SCHQ
Expense ratio 0.44% 0.03%
Holdings 245 102
Net assets, IBB as of Oct 27, 2026 and VGLT as of Sep 30, 2026 $11.0bn $10.4bn

IBB and VGLT on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

VGLT

VGLT tracks an index of Long-term Treasury. Over the year to Oct 28, 2026 it returned −6.7% with distributions reinvested, against −6.7% for its benchmark, the Bloomberg U.S. Long Treasury Index. The prospectus expense ratio is 0.03% a year. It sat 38.8% below its high of Aug 4, 2020 on Oct 28, 2026.

Questions people ask

Are IBB and VGLT in the same category?
IBB is a thematic ETF and VGLT is a bond ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or VGLT?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and VGLT −6.7%.
Which is cheaper, IBB or VGLT?
VGLT is cheaper, by 0.41 percentage points a year. That is about $41 on $10,000 held for a year. Fees come from each fund's prospectus.
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ETFIQ, IBB against VGLT, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-vglt

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